B3H2M6 (MTLD_ACTP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	APP7_1691

Organism

Actinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]

Taxonomic identifier

537457 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000099186
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	B3H2M6 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 9D6176F2C890C67E	FASTA	379	41,604
	10 20 30 40 50 60 MNALHFGAGN IGRGFIGKLL ADSGVFVTFA DINQTQIDQI NQNKQYGVKI VGDASRVEVV 70 80 90 100 110 120 KNIAAINSKD EEAVIEQVKS VELITTAVGP NVLGFIAPLF AKALAARLEA GNTQPLNIIA 130 140 150 160 170 180 CENMVRGTSF FKAKIFENLT ASQQAEIEKF VGFVDSAVDR IVPPAELNEA DPLEVTVEEF 190 200 210 220 230 240 SEWIVDKTQF KGQIPDIKGM ELTDNLMAFV ERKLFTLNTG HLISAYLGKQ AGVKWIKEAI 250 260 270 280 290 300 AIDSVKAAVK ATMEESGAVL IKRYNFDPQA HAAYIEKILK RFANPYLNDD VNRVGREPIR 310 320 330 340 350 360 KLSPNDRLIK PLLGTLEYGL PHKNLVNGVV MALQYRNEED PQAVELAQFI ADNGVAAAVE 370 KYTGLTNQEV IDQVVALYN

References

[1]	"Genome and proteome analysis of A. pleuropneumoniae serotype 7." Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AP76.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001091 Genomic DNA. Translation: ACE62343.1.
RefSeq	YP_001969485.1. NC_010939.1.
3D structure databases
ProteinModelPortal	B3H2M6.
ModBase	Search...
Protein-protein interaction databases
STRING	B3H2M6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6398002.
GenomeReviews	Gene locus APP7_1691 in contig CP001091_GR.
KEGG	apa:APP7_1691.
PATRIC	20757140. VBIActPle116979_1730.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG568825.
OMA	FANTAVD.
ProtClustDB	PRK02318.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR023027. Mannitol_DH_CS. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00009.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_ACTP7

Accession

Primary (citable) accession number: B3H2M6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program