Reviewed, UniProtKB/Swiss-Prot B3H286 (GLMM_ACTP7)

Names and origin

Protein names

Recommended name:
    Phosphoglucosamine mutase
    EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	APP7_1459

Organism

Actinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]

Taxonomic identifier

537457 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity.
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Post-translational modification	Activated by phosphorylation By similarity.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglucosamine mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 444	444	Phosphoglucosamine mutase HAMAP MF_01554		PRO_1000201054
Sites
	Active site	102	1	Phosphoserine intermediate By similarity
	Metal binding	102	1	Magnesium; via phosphate group By similarity
	Metal binding	241	1	Magnesium By similarity
	Metal binding	243	1	Magnesium By similarity
	Metal binding	245	1	Magnesium By similarity
Amino acid modifications
	Modified residue	102	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B3H286-1 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: B4C6AEDA26E63D68	FASTA	444	47,341
	10 20 30 40 50 60 MAERKYFGTD GVRGKVGQFP ITPDFALKLG WAAGKILATQ GTKQVLIGKD TRISGYMLES 70 80 90 100 110 120 ALEAGLAAAG LSAAFVGPMP TPAIAYLTRT FRAEAGIVIS ASHNPYYDNG IKFFSSVGEK 130 140 150 160 170 180 LPDEVEEAIE ALLDQPMDCV ESAQLGKAMR INDAAGRYIE FCKGTFPANA SLKGYKIVVD 190 200 210 220 230 240 CANGATYHIA PNVMRELGAE VIEIGTKPDG LNINEKCGAT DIKALQKVVV ESGADVGLAY 250 260 270 280 290 300 DGDGDRIMMV DHLGNKVDGD QILFIIAREA LRSGKLHGGV VGTLMSNMGL EVALKHLAIP 310 320 330 340 350 360 FTRANVGDRY VLEQLKEKGW KLGGENSGHI IVLDKNTTGD GIIASLEVLA AMEAHKMSLN 370 380 390 400 410 420 DLARAVPLFP QVLINVRFEG GKNPLESDAV KAVAADVEKR LAGRGRILLR KSGTEPLIRV 430 440 MVECEDGALA QSCAEEIVEA VKSN

References

[1]	"Genome and proteome analysis of A. pleuropneumoniae serotype 7." Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001091 Genomic DNA. Translation: ACE62111.1.
RefSeq	YP_001969253.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6397316.
GenomeReviews	Gene locus APP7_1459 in contig CP001091_GR.
KEGG	apa:APP7_1459.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VHDRYIE.
Family and domain databases
HAMAP	MF_01554. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. A-D-PHexomutase_N. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
TIGRFAMs	TIGR01455. glmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_ACTP7

Accession

Primary (citable) accession number: B3H286

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 22, 2008
Last modified:	November 3, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)