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Protein

Malate dehydrogenase

Gene

mdh

Organism
Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei81SubstrateUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei94NADUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Active sitei177Proton acceptorUniRule annotation1
Binding sitei231NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 13NADUniRule annotation7
Nucleotide bindingi117 – 119NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:APP7_1347
OrganismiActinobacillus pleuropneumoniae serotype 7 (strain AP76)
Taxonomic identifieri537457 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001226 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001461651 – 317Malate dehydrogenaseAdd BLAST317

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB3H269
SMRiB3H269
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213792
KOiK00024
OMAiQCTPKVE
OrthoDBiPOG091H036H

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01516 Malate_dehydrog_1, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010097 Malate_DH_type1
IPR023958 Malate_DH_type1_bac
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11540:SF22 PTHR11540:SF22, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit

Sequencei

Sequence statusi: Complete.

B3H269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVALLGAAG GIGQTLALLL KLRLPVGTDL ALYDISPVTP GIAVDISHIP
60 70 80 90 100
TSVSAVGYSG EDPSEALKGA NLVIITAGVA RKPGMTRADL FNINADIVKN
110 120 130 140 150
LVEKVAEVCP KACIGIVTNP VNTLVPIAAE VLRKAGVYDK RKLFGVTTLD
160 170 180 190 200
VVRAKTFTSE LKEKHVETVK VPVIGGHSGP TILPLLSQAL SEGLPLSFTQ
210 220 230 240 250
EEIEALTYRI QNAGTEVVEA KAGGGSATLS MAESGARFAV AVFKALLGED
260 270 280 290 300
CVRYAYVESK EGSGYPEFFA HPVRFGLTGV EELLPIGKLS EYEQAKLDEL
310
KPVLEADIAL GKNFVNP
Length:317
Mass (Da):33,405
Last modified:July 22, 2008 - v1
Checksum:i0108DFF7EDA51B35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001091 Genomic DNA Translation: ACE61999.1
RefSeqiWP_005598352.1, NC_010939.1

Genome annotation databases

EnsemblBacteriaiACE61999; ACE61999; APP7_1347
KEGGiapa:APP7_1347

Similar proteinsi

Entry informationi

Entry nameiMDH_ACTP7
AccessioniPrimary (citable) accession number: B3H269
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health