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B3H222 (PGK_ACTP7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase
EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:APP7_1300
OrganismActinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]
Taxonomic identifier537457 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP MF_00145

Subunit structure

Monomer By similarity. HAMAP MF_00145

Subcellular location

Cytoplasm Potential HAMAP MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Phosphoglycerate kinase HAMAP MF_00145
PRO_1000096316

Regions

Nucleotide binding344 – 3474ATP By similarity
Region21 – 233Substrate binding By similarity
Region59 – 624Substrate binding By similarity

Sites

Binding site361Substrate By similarity
Binding site1141Substrate By similarity
Binding site1471Substrate By similarity
Binding site1981ATP By similarity
Binding site3151ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B3H222 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 88042F440E009A86

FASTA39141,170
        10         20         30         40         50         60 
MSVIKMADLD LAGKRLFIRA DLNVPVKDGK VTSDARIRAT IPTLKLALQK GAKVMVTSHL 

        70         80         90        100        110        120 
GRPTEGVFEE ANSLQPVVDY LNASDLGVPV RLVRDYLDGV EVAENEIVVL ENVRINKGEK 

       130        140        150        160        170        180 
KNDPELAKKY AALCDVFVMD AFGTAHRAEG STYGVAEYAP VACAGPLLAA ELDALGKALK 

       190        200        210        220        230        240 
EPQRPMLAIV GGSKVSTKLT VLDSLSKIAD QLIVGGGIAN TFIAAEGHPV GKSLYEADLI 

       250        260        270        280        290        300 
PEAKRLAAAT NIPVPVDVRV GTEFSEIAPA TEKAVSEVQA DESIFDIGDK SAEELANIIK 

       310        320        330        340        350        360 
SAKTILWNGP VGVFEFPNFR KGTEVISNAI AEATANGAFS IAGGGDTLAA IDLFGIADKI 

       370        380        390 
SYISTGGGAF LEFVEGKVLP AVEILEKRAN G

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References

[1]"Genome and proteome analysis of A. pleuropneumoniae serotype 7."
Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AP76.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001091 Genomic DNA. Translation: ACE61952.1.
RefSeqYP_001969094.1. NC_010939.1.

3D structure databases

ProteinModelPortalB3H222.
SMRB3H222. Positions 2-389.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3H222.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6396177.
GenomeReviewsGene locus APP7_1300 in contig CP001091_GR.
KEGGapa:APP7_1300.
PATRIC20756263. VBIActPle116979_1329.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG453500.
OMAESMIDTC.
ProtClustDBPRK00073.

Family and domain databases

HAMAPMF_00145. Phosphoglyc_kinase.
[Tree]
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.1270. Phosphoglycerate_kinase_C. 1 hit.
G3DSA:3.40.50.1260. Phosphoglycerate_kinase_N. 1 hit.
KOK00927.
PANTHERPTHR11406. PGK. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. PGK. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_ACTP7
AccessionPrimary (citable) accession number: B3H222
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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