B3H1G9 (GPMA_ACTP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Short name=BPG-dependent PGAM
Short name=PGAM
Short name=Phosphoglyceromutase
Short name=dPGM
EC=5.4.2.1

Gene names

Name:	gpmA
Ordered Locus Names:	APP7_0889

Organism

Actinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]

Taxonomic identifier

537457 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01039
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase HAMAP MF_01039		PRO_1000135912
Sites
	Active site	8	1	Tele-phosphohistidine intermediate By similarity
	Active site	181	1	By similarity
	Site	59	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	B3H1G9 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: F2DEFAB7948BC20A	FASTA	227	25,905
	10 20 30 40 50 60 MELVFIRHGF SEWNAKNLFT GWRDVNLTER GIEEAKSAGQ KLKAAGYEFD IAFTSVLTRA 70 80 90 100 110 120 IKTCNIVLEE SNQLWIPQVK NWRLNERHYG ALQGLDKKAT AEQYGDEQVH IWRRSYDISP 130 140 150 160 170 180 PDLDAADPNS AHNDRRYAHL PKDVIPNAEN LKITLERVLP FWEDQIAPAL LSGKRVLVTA 190 200 210 220 HGNSLRALAK HIIGISDAEI MDFEIPTGQP LVLKLDDKLN FVEKFYL

References

[1]	"Genome and proteome analysis of A. pleuropneumoniae serotype 7." Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AP76.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001091 Genomic DNA. Translation: ACE61541.1.
RefSeq	YP_001968683.1. NC_010939.1.
3D structure databases
ProteinModelPortal	B3H1G9.
SMR	B3H1G9. Positions 2-227.
ModBase	Search...
Protein-protein interaction databases
STRING	B3H1G9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6395902.
GenomeReviews	Gene locus APP7_0889 in contig CP001091_GR.
KEGG	apa:APP7_0889.
PATRIC	20755413. VBIActPle116979_0911.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG658938.
OMA	EWNALNL.
ProtClustDB	PRK14118.
Family and domain databases
HAMAP	MF_01039. PGAM_GpmA. [Tree]
InterPro	IPR013078. His_Pase_superF_clade-1. IPR005952. Phosphogly_mut1. [Graphical view]
KO	K01834.
PANTHER	PTHR11931. Phosphogly_mut1. 1 hit.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. Pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA_ACTP7

Accession

Primary (citable) accession number: B3H1G9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program