Reviewed, UniProtKB/Swiss-Prot B3H169 (ACKA_ACTP7)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	APP7_0686

Organism

Actinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]

Taxonomic identifier

537457 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Acetate kinase HAMAP MF_00020		PRO_1000089956

Sequences

	Sequence		Length	Mass (Da)
	B3H169-1 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 619DA9544AEDECAB	FASTA	402	43,555
	10 20 30 40 50 60 MSKNLILILN CGSSSLKFAV LDPKTGDEKL SGLAEAFNLE DARIKWKLHG EKGNADLGAG 70 80 90 100 110 120 AAHSEALTFI ANELLSEELK SSIGAIGHRI VHGGEQFTSS VVINDDVVKG IEHAIQFAPL 130 140 150 160 170 180 HNPAHLIGIK EAFRIFPELK EKNVAVFDTA FHQTMPEEAF LYALPYKLYK EHGIRRYGAH 190 200 210 220 230 240 GTSHLFITSQ VAELAGKPVD QTNAIICHLG NGGSVSVVRN GKCIDTSMGL TPLEGLVMGT 250 260 270 280 290 300 RSGDIDPAIV FYLYKNLGMS MEQIEDTLVK KSGLLGLTEV TSDCRYAEDN YEDASKPEAK 310 320 330 340 350 360 RALDVYSYRL AKYIGAYMAI LGDDHLDAIA FTGGIGENSG HVRELALNHL KLFGVKLDVE 370 380 390 400 RNLAARFGKS GVITADDSTF KAVVIPTNEE LVIAQDTAKL AL

References

[1]	"Genome and proteome analysis of A. pleuropneumoniae serotype 7." Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001091 Genomic DNA. Translation: ACE61338.1.
RefSeq	YP_001968480.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6396295.
GenomeReviews	Gene locus APP7_0686 in contig CP001091_GR.
KEGG	apa:APP7_0686.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PHLKDKN.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate/butyrate_kinase. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_ACTP7

Accession

Primary (citable) accession number: B3H169

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 22, 2008
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)