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Protein

GMP synthase [glutamine-hydrolyzing]

Gene

guaA

Organism
Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of GMP from XMP.UniRule annotation

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851NucleophileUniRule annotation
Active sitei179 – 1791UniRule annotation
Active sitei181 – 1811UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi233 – 2397ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPLE537457:GJI0-650-MONOMER.
UniPathwayiUPA00189; UER00296.

Protein family/group databases

MEROPSiC26.957.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing]UniRule annotation (EC:6.3.5.2UniRule annotation)
Alternative name(s):
GMP synthetaseUniRule annotation
Glutamine amidotransferaseUniRule annotation
Gene namesi
Name:guaAUniRule annotation
Ordered Locus Names:APP7_0637
OrganismiActinobacillus pleuropneumoniae serotype 7 (strain AP76)
Taxonomic identifieri537457 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
ProteomesiUP000001226 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523GMP synthase [glutamine-hydrolyzing]PRO_1000120200Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi537457.APP7_0637.

Structurei

3D structure databases

ProteinModelPortaliB3H120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 205198Glutamine amidotransferase type-1UniRule annotationAdd
BLAST
Domaini206 – 398193GMPS ATP-PPaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation
Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0519.
HOGENOMiHOG000223964.
KOiK01951.
OMAiKNAKWLA.
OrthoDBiEOG6JHRJV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00344. GMP_synthase.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3H120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNIHNHKIL ILDFGSQYTQ LIARRVREIG VYCELWAWDV TEEQIREFNP
60 70 80 90 100
TGIILSGGPE STTEENSPRA QEYVFNAGVP VLGICYGMQT MAMQLGGLTE
110 120 130 140 150
TSDHREFGYA SVDLQATDAL FAKLNDNLTA SEPKLDVWMS HGDKVTRLAQ
160 170 180 190 200
GFQVTGITPT CPIAAMSDES RRFYGVQFHP EVTHTKSGLE LLTNFVVGIC
210 220 230 240 250
GCECKWTAEN IIEDAVARIK EQVGDDEVIL GLSGGVDSSV TALLLHRAIG
260 270 280 290 300
KNLHCVFVDN GLLRLNEGDQ VMEMFGDKFG LNIIRVNAED RFLDALKGID
310 320 330 340 350
EPEAKRKTIG KVFVDVFDDE SKKLTSVKWL AQGTIYPDVI ESAASKTGKA
360 370 380 390 400
HVIKSHHNVG GLPDYMKLGL VEPLRELFKD EVRKIGLALG LPAEMLNRHP
410 420 430 440 450
FPGPGLGVRV LGEIKKEYCD LLRKADAIFI EELYKADWYY KVSQAFTVFL
460 470 480 490 500
PVKSVGVMGD GRKYDWVVSL RAVETIDFMT AHWAHLPYDL LGKISNRIIN
510 520
EVNGISRVVY DVSGKPPATI EWE
Length:523
Mass (Da):58,197
Last modified:July 22, 2008 - v1
Checksum:i40AD70FB471DDDD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001091 Genomic DNA. Translation: ACE61289.1.
RefSeqiWP_012478404.1. NC_010939.1.
YP_001968431.1. NC_010939.1.

Genome annotation databases

EnsemblBacteriaiACE61289; ACE61289; APP7_0637.
KEGGiapa:APP7_0637.
PATRICi20754891. VBIActPle116979_0657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001091 Genomic DNA. Translation: ACE61289.1.
RefSeqiWP_012478404.1. NC_010939.1.
YP_001968431.1. NC_010939.1.

3D structure databases

ProteinModelPortaliB3H120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi537457.APP7_0637.

Protein family/group databases

MEROPSiC26.957.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACE61289; ACE61289; APP7_0637.
KEGGiapa:APP7_0637.
PATRICi20754891. VBIActPle116979_0657.

Phylogenomic databases

eggNOGiCOG0519.
HOGENOMiHOG000223964.
KOiK01951.
OMAiKNAKWLA.
OrthoDBiEOG6JHRJV.

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296.
BioCyciAPLE537457:GJI0-650-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00344. GMP_synthase.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome and proteome analysis of A. pleuropneumoniae serotype 7."
    Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AP76.

Entry informationi

Entry nameiGUAA_ACTP7
AccessioniPrimary (citable) accession number: B3H120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: May 27, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.