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B3H120

- GUAA_ACTP7

UniProt

B3H120 - GUAA_ACTP7

Protein

GMP synthase [glutamine-hydrolyzing]

Gene

guaA

Organism
Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of GMP from XMP.UniRule annotation

    Catalytic activityi

    ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851NucleophileUniRule annotation
    Active sitei179 – 1791UniRule annotation
    Active sitei181 – 1811UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi233 – 2397ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. GMP synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP
    3. pyrophosphatase activity Source: InterPro

    GO - Biological processi

    1. glutamine metabolic process Source: UniProtKB-HAMAP
    2. GMP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    GMP biosynthesis, Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAPLE537457:GJI0-650-MONOMER.
    UniPathwayiUPA00189; UER00296.

    Protein family/group databases

    MEROPSiC26.957.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GMP synthase [glutamine-hydrolyzing]UniRule annotation (EC:6.3.5.2UniRule annotation)
    Alternative name(s):
    GMP synthetaseUniRule annotation
    Glutamine amidotransferaseUniRule annotation
    Gene namesi
    Name:guaAUniRule annotation
    Ordered Locus Names:APP7_0637
    OrganismiActinobacillus pleuropneumoniae serotype 7 (strain AP76)
    Taxonomic identifieri537457 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
    ProteomesiUP000001226: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523GMP synthase [glutamine-hydrolyzing]PRO_1000120200Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi537457.APP7_0637.

    Structurei

    3D structure databases

    ProteinModelPortaliB3H120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 205198Glutamine amidotransferase type-1UniRule annotationAdd
    BLAST
    Domaini206 – 398193GMPS ATP-PPaseUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation
    Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0519.
    HOGENOMiHOG000223964.
    KOiK01951.
    OMAiMHKAIGD.
    OrthoDBiEOG6JHRJV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPiMF_00344. GMP_synthase.
    InterProiIPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR001674. GMP_synth_C.
    IPR004739. GMP_synth_N.
    IPR022955. GMP_synthase.
    IPR025777. GMPS_ATP_PPase_dom.
    IPR022310. NAD/GMP_synthase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00117. GATase. 1 hit.
    PF00958. GMP_synt_C. 1 hit.
    PF02540. NAD_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
    TIGR00888. guaA_Nterm. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    PS51553. GMPS_ATP_PPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3H120-1 [UniParc]FASTAAdd to Basket

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    MTNIHNHKIL ILDFGSQYTQ LIARRVREIG VYCELWAWDV TEEQIREFNP    50
    TGIILSGGPE STTEENSPRA QEYVFNAGVP VLGICYGMQT MAMQLGGLTE 100
    TSDHREFGYA SVDLQATDAL FAKLNDNLTA SEPKLDVWMS HGDKVTRLAQ 150
    GFQVTGITPT CPIAAMSDES RRFYGVQFHP EVTHTKSGLE LLTNFVVGIC 200
    GCECKWTAEN IIEDAVARIK EQVGDDEVIL GLSGGVDSSV TALLLHRAIG 250
    KNLHCVFVDN GLLRLNEGDQ VMEMFGDKFG LNIIRVNAED RFLDALKGID 300
    EPEAKRKTIG KVFVDVFDDE SKKLTSVKWL AQGTIYPDVI ESAASKTGKA 350
    HVIKSHHNVG GLPDYMKLGL VEPLRELFKD EVRKIGLALG LPAEMLNRHP 400
    FPGPGLGVRV LGEIKKEYCD LLRKADAIFI EELYKADWYY KVSQAFTVFL 450
    PVKSVGVMGD GRKYDWVVSL RAVETIDFMT AHWAHLPYDL LGKISNRIIN 500
    EVNGISRVVY DVSGKPPATI EWE 523
    Length:523
    Mass (Da):58,197
    Last modified:July 22, 2008 - v1
    Checksum:i40AD70FB471DDDD7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001091 Genomic DNA. Translation: ACE61289.1.
    RefSeqiYP_001968431.1. NC_010939.1.

    Genome annotation databases

    EnsemblBacteriaiACE61289; ACE61289; APP7_0637.
    GeneIDi6396394.
    KEGGiapa:APP7_0637.
    PATRICi20754891. VBIActPle116979_0657.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001091 Genomic DNA. Translation: ACE61289.1 .
    RefSeqi YP_001968431.1. NC_010939.1.

    3D structure databases

    ProteinModelPortali B3H120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 537457.APP7_0637.

    Protein family/group databases

    MEROPSi C26.957.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE61289 ; ACE61289 ; APP7_0637 .
    GeneIDi 6396394.
    KEGGi apa:APP7_0637.
    PATRICi 20754891. VBIActPle116979_0657.

    Phylogenomic databases

    eggNOGi COG0519.
    HOGENOMi HOG000223964.
    KOi K01951.
    OMAi MHKAIGD.
    OrthoDBi EOG6JHRJV.

    Enzyme and pathway databases

    UniPathwayi UPA00189 ; UER00296 .
    BioCyci APLE537457:GJI0-650-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPi MF_00344. GMP_synthase.
    InterProi IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR001674. GMP_synth_C.
    IPR004739. GMP_synth_N.
    IPR022955. GMP_synthase.
    IPR025777. GMPS_ATP_PPase_dom.
    IPR022310. NAD/GMP_synthase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00117. GATase. 1 hit.
    PF00958. GMP_synt_C. 1 hit.
    PF02540. NAD_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    TIGRFAMsi TIGR00884. guaA_Cterm. 1 hit.
    TIGR00888. guaA_Nterm. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    PS51553. GMPS_ATP_PPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome and proteome analysis of A. pleuropneumoniae serotype 7."
      Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AP76.

    Entry informationi

    Entry nameiGUAA_ACTP7
    AccessioniPrimary (citable) accession number: B3H120
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3