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B3H120

- GUAA_ACTP7

UniProt

B3H120 - GUAA_ACTP7

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Protein
GMP synthase [glutamine-hydrolyzing]
Gene
guaA, APP7_0637
Organism
Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of GMP from XMP By similarity.UniRule annotation

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Nucleophile By similarity
Active sitei179 – 1791 By similarity
Active sitei181 – 1811 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi233 – 2397ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. GMP synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP
  3. pyrophosphatase activity Source: InterPro

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPLE537457:GJI0-650-MONOMER.
UniPathwayiUPA00189; UER00296.

Protein family/group databases

MEROPSiC26.957.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] (EC:6.3.5.2)
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene namesi
Name:guaA
Ordered Locus Names:APP7_0637
OrganismiActinobacillus pleuropneumoniae serotype 7 (strain AP76)
Taxonomic identifieri537457 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
ProteomesiUP000001226: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523GMP synthase [glutamine-hydrolyzing]UniRule annotation
PRO_1000120200Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi537457.APP7_0637.

Structurei

3D structure databases

ProteinModelPortaliB3H120.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 205198Glutamine amidotransferase type-1
Add
BLAST
Domaini206 – 398193GMPS ATP-PPase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0519.
HOGENOMiHOG000223964.
KOiK01951.
OMAiMHKAIGD.
OrthoDBiEOG6JHRJV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00344. GMP_synthase.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3H120-1 [UniParc]FASTAAdd to Basket

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MTNIHNHKIL ILDFGSQYTQ LIARRVREIG VYCELWAWDV TEEQIREFNP    50
TGIILSGGPE STTEENSPRA QEYVFNAGVP VLGICYGMQT MAMQLGGLTE 100
TSDHREFGYA SVDLQATDAL FAKLNDNLTA SEPKLDVWMS HGDKVTRLAQ 150
GFQVTGITPT CPIAAMSDES RRFYGVQFHP EVTHTKSGLE LLTNFVVGIC 200
GCECKWTAEN IIEDAVARIK EQVGDDEVIL GLSGGVDSSV TALLLHRAIG 250
KNLHCVFVDN GLLRLNEGDQ VMEMFGDKFG LNIIRVNAED RFLDALKGID 300
EPEAKRKTIG KVFVDVFDDE SKKLTSVKWL AQGTIYPDVI ESAASKTGKA 350
HVIKSHHNVG GLPDYMKLGL VEPLRELFKD EVRKIGLALG LPAEMLNRHP 400
FPGPGLGVRV LGEIKKEYCD LLRKADAIFI EELYKADWYY KVSQAFTVFL 450
PVKSVGVMGD GRKYDWVVSL RAVETIDFMT AHWAHLPYDL LGKISNRIIN 500
EVNGISRVVY DVSGKPPATI EWE 523
Length:523
Mass (Da):58,197
Last modified:July 22, 2008 - v1
Checksum:i40AD70FB471DDDD7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001091 Genomic DNA. Translation: ACE61289.1.
RefSeqiYP_001968431.1. NC_010939.1.

Genome annotation databases

EnsemblBacteriaiACE61289; ACE61289; APP7_0637.
GeneIDi6396394.
KEGGiapa:APP7_0637.
PATRICi20754891. VBIActPle116979_0657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001091 Genomic DNA. Translation: ACE61289.1 .
RefSeqi YP_001968431.1. NC_010939.1.

3D structure databases

ProteinModelPortali B3H120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 537457.APP7_0637.

Protein family/group databases

MEROPSi C26.957.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE61289 ; ACE61289 ; APP7_0637 .
GeneIDi 6396394.
KEGGi apa:APP7_0637.
PATRICi 20754891. VBIActPle116979_0657.

Phylogenomic databases

eggNOGi COG0519.
HOGENOMi HOG000223964.
KOi K01951.
OMAi MHKAIGD.
OrthoDBi EOG6JHRJV.

Enzyme and pathway databases

UniPathwayi UPA00189 ; UER00296 .
BioCyci APLE537457:GJI0-650-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPi MF_00344. GMP_synthase.
InterProi IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome and proteome analysis of A. pleuropneumoniae serotype 7."
    Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AP76.

Entry informationi

Entry nameiGUAA_ACTP7
AccessioniPrimary (citable) accession number: B3H120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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