B3H084 (ARGB_ACTP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	APP7_0244

Organism

Actinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]

Taxonomic identifier

537457 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Acetylglutamate kinase HAMAP MF_00082_B		PRO_1000092844
Regions
	Region	66 – 67	2	Substrate binding By similarity
Sites
	Binding site	88	1	Substrate By similarity
	Binding site	179	1	Substrate By similarity
	Site	31	1	Transition state stabilizer By similarity
	Site	242	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	B3H084 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 7A1756715E71C3B4	FASTA	284	30,275
	10 20 30 40 50 60 MLQNEVENFA NLLEQATVYL APYQEKIIVV KYGGNAMINE DLKKLVMQDI LLLNQLGVKV 70 80 90 100 110 120 VLVHGGGPEI SQGVKLLGKE PQFINGLRVT DQDTINVVLQ MLAGKVNKSL VALLKGKGVG 130 140 150 160 170 180 LCGIDANMLQ CEKLQAEVDY GFVGEIVKVN TQLLELALSA NLIPVISTVG VDDQGVAYNI 190 200 210 220 230 240 NADTVASEIA MALGAAKLVS MTDIAGLLRD RFDESTLIPE VEVSEVQGLI DQGIIAGGMI 250 260 270 280 PKIACCTDFI NAGGIEANII DGRVPHAILV SLFGGKNGTL FYKK

References

[1]	"Genome and proteome analysis of A. pleuropneumoniae serotype 7." Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AP76.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001091 Genomic DNA. Translation: ACE60896.1.
RefSeq	YP_001968038.1. NC_010939.1.
3D structure databases
ProteinModelPortal	B3H084.
ModBase	Search...
Protein-protein interaction databases
STRING	B3H084.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6397148.
GenomeReviews	Gene locus APP7_0244 in contig CP001091_GR.
KEGG	apa:APP7_0244.
PATRIC	20754055. VBIActPle116979_0248.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG497643.
OMA	GGNAMID.
ProtClustDB	PRK00942.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ACTP7

Accession

Primary (citable) accession number: B3H084

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program