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B3H035 (AROB_ACTP7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:APP7_0195
OrganismActinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]
Taxonomic identifier537457 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3663663-dehydroquinate synthase HAMAP MF_00110
PRO_1000094445

Sequences

Sequence LengthMass (Da)Tools
B3H035 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: F3C60FC8D52DE93A

FASTA36640,043
        10         20         30         40         50         60 
MLQVNVELKE RRYPITIGAG LLGDPNSYSS LKAGDKVMIV SNPTVAAHYL ATVTNTLNGL 

        70         80         90        100        110        120 
GCSVDSVLIP DGEKYKTLDS LNMIFTALLE KNHNRDTTLI ALGGGVIGDV AGYAAASYQR 

       130        140        150        160        170        180 
GIRFIQIPTT LLAQVDSSVG GKTAVNHPLG KNMIGAFYQP ISVIIDTNTL QTLPKREVSA 

       190        200        210        220        230        240 
GLAEVIKYGA IFDIHFFEWL ESNIHHLVAL KQNELEYCIQ RCCQLKADVV ARDETEKGDR 

       250        260        270        280        290        300 
ALLNLGHTFG HAIEAHLGYG NWLHGEAVSV GMLEAAELSR ILGDLSAQDV SRLERLLAQA 

       310        320        330        340        350        360 
VLPTISPDGM EPSEYLPYMW RDKKVLGGQL RLVLLKSLGK AYVTAQASEQ QVLSAIERFT 


QREFHE

« Hide

References

[1]"Genome and proteome analysis of A. pleuropneumoniae serotype 7."
Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AP76.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001091 Genomic DNA. Translation: ACE60847.1.
RefSeqYP_001967989.1. NC_010939.1.

3D structure databases

ProteinModelPortalB3H035.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3H035.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6397240.
GenomeReviewsGene locus APP7_0195 in contig CP001091_GR.
KEGGapa:APP7_0195.
PATRIC20753953. VBIActPle116979_0198.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMAVMALEMS.
ProtClustDBPRK00002.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_ACTP7
AccessionPrimary (citable) accession number: B3H035
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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