Reviewed, UniProtKB/Swiss-Prot B3H035 (AROB_ACTP7)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	APP7_0195

Organism

Actinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]

Taxonomic identifier

537457 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094445

Sequences

	Sequence		Length	Mass (Da)
	B3H035-1 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: F3C60FC8D52DE93A	FASTA	366	40,043
	10 20 30 40 50 60 MLQVNVELKE RRYPITIGAG LLGDPNSYSS LKAGDKVMIV SNPTVAAHYL ATVTNTLNGL 70 80 90 100 110 120 GCSVDSVLIP DGEKYKTLDS LNMIFTALLE KNHNRDTTLI ALGGGVIGDV AGYAAASYQR 130 140 150 160 170 180 GIRFIQIPTT LLAQVDSSVG GKTAVNHPLG KNMIGAFYQP ISVIIDTNTL QTLPKREVSA 190 200 210 220 230 240 GLAEVIKYGA IFDIHFFEWL ESNIHHLVAL KQNELEYCIQ RCCQLKADVV ARDETEKGDR 250 260 270 280 290 300 ALLNLGHTFG HAIEAHLGYG NWLHGEAVSV GMLEAAELSR ILGDLSAQDV SRLERLLAQA 310 320 330 340 350 360 VLPTISPDGM EPSEYLPYMW RDKKVLGGQL RLVLLKSLGK AYVTAQASEQ QVLSAIERFT QREFHE

References

[1]	"Genome and proteome analysis of A. pleuropneumoniae serotype 7." Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001091 Genomic DNA. Translation: ACE60847.1.
RefSeq	YP_001967989.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6397240.
GenomeReviews	Gene locus APP7_0195 in contig CP001091_GR.
KEGG	apa:APP7_0195.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EDYLPHM.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_ACTP7

Accession

Primary (citable) accession number: B3H035

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 22, 2008
Last modified:	November 3, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)