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B3GZJ7

- LPXB_ACTP7

UniProt

B3GZJ7 - LPXB_ACTP7

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciAPLE537457:GJI0-7-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:APP7_0007
    OrganismiActinobacillus pleuropneumoniae serotype 7 (strain AP76)
    Taxonomic identifieri537457 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
    ProteomesiUP000001226: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Lipid-A-disaccharide synthasePRO_1000191457Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi537457.APP7_0007.

    Structurei

    3D structure databases

    ProteinModelPortaliB3GZJ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiEWTINPP.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3GZJ7-1 [UniParc]FASTAAdd to Basket

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    MIKKEAPLIA LVAGEISGDI LGAGLINALK LHYPNARFIG VAGPRMIQAG    50
    CETLFDMEEL AVMGLAEVVK HLPRLLKRRK QVIETMLAEK PDIFIGIDAP 100
    DFNLTVEEKL KASGIKTIHY VSPSVWAWRQ NRVQKIARAT NLVLAFLPFE 150
    KAFYDRFNVP CRFIGHTMAD AIALKPNRSE ACATLNLDET QRYLAILVGS 200
    RASEVRFLAE PFLKAAKILK QQYPDLQFLV PLVNDKRIAQ FEQIKAQVAP 250
    ELSVHILKGN ARQAMIAAEA SLLASGTAAL EGMLCKSPMV VGYKMKAMTY 300
    WLAKRLVKTK YISLPNLLAD EMLVPELIQD ECNPENLAWY LGNYLADDAD 350
    HRKQRNELKQ RFTELHKLIQ CDADAQAAQA VVDVLEANTS DQN 393
    Length:393
    Mass (Da):43,880
    Last modified:July 22, 2008 - v1
    Checksum:iEAA9F7279B6442ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001091 Genomic DNA. Translation: ACE60659.1.
    RefSeqiYP_001967801.1. NC_010939.1.

    Genome annotation databases

    EnsemblBacteriaiACE60659; ACE60659; APP7_0007.
    GeneIDi6397623.
    KEGGiapa:APP7_0007.
    PATRICi20753559. VBIActPle116979_0007.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001091 Genomic DNA. Translation: ACE60659.1 .
    RefSeqi YP_001967801.1. NC_010939.1.

    3D structure databases

    ProteinModelPortali B3GZJ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 537457.APP7_0007.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE60659 ; ACE60659 ; APP7_0007 .
    GeneIDi 6397623.
    KEGGi apa:APP7_0007.
    PATRICi 20753559. VBIActPle116979_0007.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi EWTINPP.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci APLE537457:GJI0-7-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome and proteome analysis of A. pleuropneumoniae serotype 7."
      Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AP76.

    Entry informationi

    Entry nameiLPXB_ACTP7
    AccessioniPrimary (citable) accession number: B3GZJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3