B3GYC3 (CDD_ACTP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidine deaminase
EC=3.5.4.5

Alternative name(s):
Cytidine aminohydrolase
Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	APP7_1395

Organism

Actinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]

Taxonomic identifier

537457 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP MF_01558
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity. HAMAP MF_01558
Subunit structure	Homodimer By similarity. HAMAP MF_01558
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Cytidine deaminase HAMAP MF_01558		PRO_1000147093
Regions
	Region	95 – 97	3	Substrate binding By similarity
Sites
	Active site	110	1	Proton donor By similarity
	Metal binding	108	1	Zinc; catalytic By similarity
	Metal binding	135	1	Zinc; catalytic By similarity
	Metal binding	138	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	B3GYC3 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: BB3AE44FAC5CEAEF	FASTA	297	32,812
	10 20 30 40 50 60 MPTLFALKER IAQVVQEKND PIVTAVATTL AEQQYNACFS AEQVKLWKRQ FKCSSVELAL 70 80 90 100 110 120 ACLPIAACYA LVPISNFYVG AVAIGESGRF YFGANQEFNA QAIQQTVHAE QSAISHAWLA 130 140 150 160 170 180 GETAITDMVV NYTPCGHCRQ FMNELNSAKT LKIHLPHSQN NLLRQYLPDS FGPKDLNIEK 190 200 210 220 230 240 VLFDQQTHSL PLRGDLLTQA AIQTAAQSYA PYSKSLSGIA LQVGEQIICG RYAENAAFNP 250 260 270 280 290 SFLPLQSALN YRRLSGKSDE RISRIVMAES KGTTSHRQMS EALAESFLGL NLEYIEV

References

[1]	"Genome and proteome analysis of A. pleuropneumoniae serotype 7." Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AP76.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001091 Genomic DNA. Translation: ACE62047.1.
RefSeq	YP_001969189.1. NC_010939.1.
3D structure databases
ProteinModelPortal	B3GYC3.
ModBase	Search...
Protein-protein interaction databases
STRING	B3GYC3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6397421.
GenomeReviews	Gene locus APP7_1395 in contig CP001091_GR.
KEGG	apa:APP7_1395.
PATRIC	20756481. VBIActPle116979_1426.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG591160.
OMA	NRSHAPY.
ProtClustDB	PRK09027.
Family and domain databases
HAMAP	MF_01558. Cyt_deam. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn-bd. IPR013171. Cyd/dCyd_deaminase_Zn-bd. IPR006263. Cyt_deam_dimer. IPR016193. Cytidine_deaminase-like. IPR020797. Cytidine_deaminase_bacteria. [Graphical view]
KO	K01489.
PANTHER	PTHR11644:SF12. PTHR11644:SF12. 1 hit.
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
PIRSF	PIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAM	SSF53927. Cytidine_deaminase-like. 2 hits.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_ACTP7

Accession

Primary (citable) accession number: B3GYC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program