Reviewed, UniProtKB/Swiss-Prot B3GY96 (OTC_ACTP7)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	APP7_1368

Organism

Actinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]

Taxonomic identifier

537457 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000137085
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	273 – 276	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	B3GY96-1 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: C6EEC2C88054120A	FASTA	334	37,339
	10 20 30 40 50 60 MAFNLKNRHL LSLVNHTERE IKFLLDLSRD LKRAKYAGTE QQRLKGKNIA LIFEKTSTRT 70 80 90 100 110 120 RCAFEVAAYD QGAHVTYIDP TSSQIGHKES MKDTARVLGR MYDAIEYRGF KQSVVNELAE 130 140 150 160 170 180 YAGVPVFNGL TDEFHPTQML ADVLTMIENC EKPLSQISYV YIGDARNNVG NSLLLIGAKL 190 200 210 220 230 240 GMDVRICAPK ALLPEDSLVE MCQKFAAESG ARITVTDDID TAVKGVDFVH TDVWVSMGEP 250 260 270 280 290 300 LETWGERIDM LMPYQVTPEL MKRTGNPKVK FMHCLPAFHN SETKIGKQVA EKYPALANGI 310 320 330 EVTEDVFESP ANVAFEQAEN RMHTIKAVMV ASLA

References

[1]	"Genome and proteome analysis of A. pleuropneumoniae serotype 7." Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001091 Genomic DNA. Translation: ACE62020.1.
RefSeq	YP_001969162.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6397017.
GenomeReviews	Gene locus APP7_1368 in contig CP001091_GR.
KEGG	apa:APP7_1368.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NPNVKFM.
Family and domain databases
HAMAP	MF_01109. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_ACTP7

Accession

Primary (citable) accession number: B3GY96

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 22, 2008
Last modified:	November 3, 2009
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)