B3GY67 (ARLY_ACTP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	APP7_1238

Organism

Actinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]

Taxonomic identifier

537457 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Argininosuccinate lyase HAMAP MF_00006		PRO_1000089062

Sequences

	Sequence		Length	Mass (Da)
	B3GY67 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: FDF8C99AEDB81BD5	FASTA	458	51,048
	10 20 30 40 50 60 MALWGGRFKQ EADAKFKFFN DSLRFDYRLA LQDIDGSIGW AKAITSVGIL TEQEHQQLVV 70 80 90 100 110 120 ALKELRAEIE PNIAIILRDD AEDIHSWVES KLIEKVGDLG KKLHTGRSRN DQVAVDMKMW 130 140 150 160 170 180 CKVQAVVLQE RIRNLQHKLV ETAEANQNAV MPGYTHLQRA QPITFAHWCM AYYEMLERDF 190 200 210 220 230 240 SRLSDAYKRM HTCPLGSGAL AGTAYSIDRD ALAQDLGFSI GTRNSLDSVS DRDHVLELLS 250 260 270 280 290 300 TASISMVHLS RFAEDLIFFN SGESAFLELS DRVTSGSSLM PQKKNPDACE LIRGKSGRVF 310 320 330 340 350 360 GALSGLLTTL KGLPLAYNKD MQEDKEGIFD AMETWQACLE IGALVLEDIN VNVERTREAA 370 380 390 400 410 420 QQGYSNATEL ADYLVAKGIP FREAHHIVGE AVVYAISKRE PLEALSVAEF KQFHPVIDED 430 440 450 VYPILSLESC LEKRSAKGGV NPERVREAIE AAKVNLGA

References

[1]	"Genome and proteome analysis of A. pleuropneumoniae serotype 7." Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AP76.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001091 Genomic DNA. Translation: ACE61890.1.
RefSeq	YP_001969032.1. NC_010939.1.
3D structure databases
ProteinModelPortal	B3GY67.
ModBase	Search...
Protein-protein interaction databases
STRING	B3GY67.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6397943.
GenomeReviews	Gene locus APP7_1238 in contig CP001091_GR.
KEGG	apa:APP7_1238.
PATRIC	20756137. VBIActPle116979_1266.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG539632.
OMA	MAEDLIF.
ProtClustDB	PRK04833.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ACTP7

Accession

Primary (citable) accession number: B3GY67

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program