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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei384 – 3841UniRule annotation
Active sitei512 – 5121UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciAPLE537457:GJI0-1217-MONOMER.
UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:APP7_1195
OrganismiActinobacillus pleuropneumoniae serotype 7 (strain AP76)
Taxonomic identifieri537457 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
ProteomesiUP000001226 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546Glucose-6-phosphate isomerasePRO_1000125686Add
BLAST

Proteomic databases

PRIDEiB3GY24.

Interactioni

Protein-protein interaction databases

STRINGi537457.APP7_1195.

Structurei

3D structure databases

ProteinModelPortaliB3GY24.
SMRiB3GY24. Positions 17-546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3GY24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNINPTQTA AWSALEQHKA DNLNIPQLFA EDANRFDKYH LNFEQQILVD
60 70 80 90 100
FSKNAINQKT LELLRQLANE CGLASATEAM FSGQKINRTE NRAVLHTALR
110 120 130 140 150
NRSNTPVLVD GKDVMPEVNA VLAKMKDFCE RIISGSWKGY TGKAITDVIN
160 170 180 190 200
IGIGGSDLGP YMVTEALRPY KNHLNMHFVS NVDGTHIAEV LKKVNPETTL
210 220 230 240 250
VLVASKTFTT QETMTNALTA REWLLAAVKD ESAVAKHFAA LSTNAKEVAK
260 270 280 290 300
FGIDTANMFE FWDWVGGRYS LWSAIGLSIA LSLGFENFEA LLSGAHAMDN
310 320 330 340 350
HFRTAPIEKN IPTTLALIGI WNSNFLGAET EALLPYDQYL HRFAAYFQQG
360 370 380 390 400
NMESNGKFVG RDGSPVTHQT GPIVWGEPGT NGQHAFYQLI HQGTKLIPCD
410 420 430 440 450
FIAPAQTHNP VGDHHAKLLS NFFAQTEALA FGKSKETVEA EFVAAGKNLA
460 470 480 490 500
DVAEIVPFKV FTGNKPTNSI LVQKITPFTL GALIAMYEHK IFVQGVIFNI
510 520 530 540
YSFDQWGVEL GKQLANRILP ELQNAEKISS HDSSTNGLIN QFKAWR
Length:546
Mass (Da):60,415
Last modified:July 22, 2008 - v1
Checksum:i6787F092BEE82DEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001091 Genomic DNA. Translation: ACE61847.1.
RefSeqiYP_001968989.1. NC_010939.1.

Genome annotation databases

EnsemblBacteriaiACE61847; ACE61847; APP7_1195.
KEGGiapa:APP7_1195.
PATRICi20756037. VBIActPle116979_1220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001091 Genomic DNA. Translation: ACE61847.1.
RefSeqiYP_001968989.1. NC_010939.1.

3D structure databases

ProteinModelPortaliB3GY24.
SMRiB3GY24. Positions 17-546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi537457.APP7_1195.

Proteomic databases

PRIDEiB3GY24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACE61847; ACE61847; APP7_1195.
KEGGiapa:APP7_1195.
PATRICi20756037. VBIActPle116979_1220.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.
BioCyciAPLE537457:GJI0-1217-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome and proteome analysis of A. pleuropneumoniae serotype 7."
    Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AP76.

Entry informationi

Entry nameiG6PI_ACTP7
AccessioniPrimary (citable) accession number: B3GY24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: April 29, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.