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B3GY11 (K6PF_ACTP7) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphofructokinase

Short name=Phosphofructokinase
EC=2.7.1.11
Alternative name(s):
Phosphohexokinase
Gene names
Name:pfkA
Ordered Locus Names:APP7_1182
OrganismActinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]
Taxonomic identifier537457 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfructose 6-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_component6-phosphofructokinase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_function6-phosphofructokinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3243246-phosphofructokinase HAMAP-Rule MF_00339
PRO_1000120022

Regions

Nucleotide binding25 – 295ATP By similarity
Nucleotide binding159 – 1635ATP By similarity
Nucleotide binding176 – 19217ATP By similarity

Sites

Active site1321Proton acceptor By similarity
Metal binding1901Magnesium; via carbonyl oxygen By similarity
Metal binding1921Magnesium By similarity
Binding site1671Substrate By similarity
Binding site2481Substrate By similarity
Binding site2541Substrate By similarity
Binding site2571Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B3GY11 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 1D2C62562BBD6586

FASTA32435,515
        10         20         30         40         50         60 
MAKQIKKIAV LTSGGDAPGM NAAIRGVVRA ALNEGLEVYG VQDGYYGLYT DRVIPLDRRS 

        70         80         90        100        110        120 
VSETINRGGT FLGSARFPQF KDPDVRKKSV ETLKKYDIDA LVVIGGDGSY MGAKLITEEF 

       130        140        150        160        170        180 
GYPCIGIPGT IDNDIVGTDY TIGYQTALET AVEAIDRLRD TSTSHQRISI VEIMGRHCGD 

       190        200        210        220        230        240 
LTISAALASG CEYIIVPEKG LDKESLMRNI EDGFNKGKRH AIIAITELMT DVQALAKEIE 

       250        260        270        280        290        300 
DRFGHETRAT VLGHIQRGGA PCPFDRILAS RMGVYAVDLL LQGHGGRCIG IKNENLVHHD 

       310        320 
IIDAINNMRR PFKEELFEAA RKLF 

« Hide

References

[1]"Genome and proteome analysis of A. pleuropneumoniae serotype 7."
Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AP76.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001091 Genomic DNA. Translation: ACE61834.1.
RefSeqYP_001968976.1. NC_010939.1.

3D structure databases

ProteinModelPortalB3GY11.
SMRB3GY11. Positions 5-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING537457.APP7_1182.

Proteomic databases

PRIDEB3GY11.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACE61834; ACE61834; APP7_1182.
GeneID6397864.
KEGGapa:APP7_1182.
PATRIC20756011. VBIActPle116979_1207.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0205.
HOGENOMHOG000248870.
KOK00850.
OMAKMVHHDI.
OrthoDBEOG644ZRM.
ProtClustDBPRK03202.

Enzyme and pathway databases

BioCycAPLE537457:GJI0-1204-MONOMER.
UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
TIGRFAMsTIGR02482. PFKA_ATP. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK6PF_ACTP7
AccessionPrimary (citable) accession number: B3GY11
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways