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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi13Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi16Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi95Iron-sulfur (4Fe-4S)UniRule annotation1
Binding sitei220S-adenosyl-L-methionineUniRule annotation1
Binding sitei249S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei276S-adenosyl-L-methionineUniRule annotation1
Binding sitei322S-adenosyl-L-methionineUniRule annotation1
Active sitei349NucleophileUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Ordered Locus Names:APP7_1170
OrganismiActinobacillus pleuropneumoniae serotype 7 (strain AP76)
Taxonomic identifieri537457 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001226 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004148161 – 39123S rRNA (uracil(747)-C(5))-methyltransferase RlmCAdd BLAST391

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218547.
KOiK03212.
OMAiQTNSYAL.
OrthoDBiPOG091H00VG.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC. 1 hit.
InterProiIPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR030391. MeTrfase_TrmA_CS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3GXZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNCPHFQQ QDCVSCQWLE KPYATQLTDK EIDLKRLISP FILQNFTEIL
60 70 80 90 100
PPVQSSQKQF RNKAKMVVSG SVERPILGIL KDQTDPQSGI DLCDCPLYPT
110 120 130 140 150
EFEALFPILK DFIARAGLVP YNIAKKKGEL KYILLTQSRY NQSIMLRFVL
160 170 180 190 200
KSEQKRPLVE RELPNLLAKL PKDSVVSLNI QPQHAAILEG ETEIFLTEKT
210 220 230 240 250
TIEENFNDIP LFIRPQGFFQ TNPNVASQLY ATAQNWIKDL AIQQFWDLFC
260 270 280 290 300
GVGGFGLHCA KALQEKNENV QLTSIEISAS AIASATKSAE QLQLKNITFA
310 320 330 340 350
SLDSAQFALN EKSATPDLVI VNPPRRGIGK PLAEFLNQLG TPYLIYSSCN
360 370 380 390
ARTMAQDFEA LSNYSLQKVQ LFDMFPHTSH YEVLTFLVKK S
Length:391
Mass (Da):44,167
Last modified:July 22, 2008 - v1
Checksum:i7D8A70C03AB41A99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001091 Genomic DNA. Translation: ACE61822.1.
RefSeqiWP_005617603.1. NC_010939.1.

Genome annotation databases

EnsemblBacteriaiACE61822; ACE61822; APP7_1170.
KEGGiapa:APP7_1170.
PATRICi20755987. VBIActPle116979_1195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001091 Genomic DNA. Translation: ACE61822.1.
RefSeqiWP_005617603.1. NC_010939.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACE61822; ACE61822; APP7_1170.
KEGGiapa:APP7_1170.
PATRICi20755987. VBIActPle116979_1195.

Phylogenomic databases

HOGENOMiHOG000218547.
KOiK03212.
OMAiQTNSYAL.
OrthoDBiPOG091H00VG.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC. 1 hit.
InterProiIPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR030391. MeTrfase_TrmA_CS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRLMC_ACTP7
AccessioniPrimary (citable) accession number: B3GXZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.