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B3GXZ7

- NAGZ_ACTP7

UniProt

B3GXZ7 - NAGZ_ACTP7

Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei60 – 601SubstrateUniRule annotation
    Binding sitei68 – 681SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei173 – 1731Important for catalytic activityUniRule annotation
    Active sitei175 – 1751Proton donor/acceptorUniRule annotation
    Active sitei247 – 2471NucleophileUniRule annotation

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell cycle Source: UniProtKB-KW
    3. cell division Source: UniProtKB-KW
    4. peptidoglycan biosynthetic process Source: UniProtKB-KW
    5. peptidoglycan turnover Source: UniProtKB-HAMAP
    6. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciAPLE537457:GJI0-1190-MONOMER.
    UniPathwayiUPA00544.

    Protein family/group databases

    CAZyiGH3. Glycoside Hydrolase Family 3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
    Alternative name(s):
    Beta-N-acetylhexosaminidaseUniRule annotation
    N-acetyl-beta-glucosaminidaseUniRule annotation
    Gene namesi
    Name:nagZUniRule annotation
    Ordered Locus Names:APP7_1168
    OrganismiActinobacillus pleuropneumoniae serotype 7 (strain AP76)
    Taxonomic identifieri537457 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
    ProteomesiUP000001226: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 345345Beta-hexosaminidasePRO_1000121051Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi537457.APP7_1168.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni162 – 1632Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000248526.
    KOiK01207.
    OMAiHILALYE.
    OrthoDBiEOG6BCT06.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    HAMAPiMF_00364. NagZ.
    InterProiIPR022956. Beta_hexosaminidase_bac.
    IPR019800. Glyco_hydro_3_AS.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00933. Glyco_hydro_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3GXZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLIDIKDKE LSQEEVEILE HPLVSGLILF SRNFHDKVQL EALVKSIRQR    50
    VKKPLLITVD QEGGRVQRFR EGFTKLPAMQ AFHTLAKNPQ ESTALARQTG 100
    WLMAAEMFAL DIDLSFAPVL DLGHQCKAIG DRSFGENPDA MLPIAEAFID 150
    GMREMGMATT GKHFPGHGHV LADSHLETPF DDRPKEAIFN RDILPFKQLI 200
    SKGKLSAIMP AHVIYTQCDS QPASGSEYWL KQVLRNQLNF NGVIFSDDLG 250
    MKGAGFMGNF VERSEKAIHA GCDLLLLCNE PEGVIQVLDG LKYQPTKTQT 300
    ERHISLMKRK TVRWNELEAS PRYQQAQQRL TALQNDWLEY KAQHC 345
    Length:345
    Mass (Da):38,994
    Last modified:July 22, 2008 - v1
    Checksum:iAB16DBBA7B4F3CDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001091 Genomic DNA. Translation: ACE61820.1.
    RefSeqiYP_001968962.1. NC_010939.1.

    Genome annotation databases

    EnsemblBacteriaiACE61820; ACE61820; APP7_1168.
    GeneIDi6397914.
    KEGGiapa:APP7_1168.
    PATRICi20755983. VBIActPle116979_1193.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001091 Genomic DNA. Translation: ACE61820.1 .
    RefSeqi YP_001968962.1. NC_010939.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 537457.APP7_1168.

    Protein family/group databases

    CAZyi GH3. Glycoside Hydrolase Family 3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE61820 ; ACE61820 ; APP7_1168 .
    GeneIDi 6397914.
    KEGGi apa:APP7_1168.
    PATRICi 20755983. VBIActPle116979_1193.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000248526.
    KOi K01207.
    OMAi HILALYE.
    OrthoDBi EOG6BCT06.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci APLE537457:GJI0-1190-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    HAMAPi MF_00364. NagZ.
    InterProi IPR022956. Beta_hexosaminidase_bac.
    IPR019800. Glyco_hydro_3_AS.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00933. Glyco_hydro_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome and proteome analysis of A. pleuropneumoniae serotype 7."
      Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AP76.

    Entry informationi

    Entry nameiNAGZ_ACTP7
    AccessioniPrimary (citable) accession number: B3GXZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3