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B3GXD4 (AROA_ACTP7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:APP7_0741
OrganismActinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]
Taxonomic identifier537457 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4324323-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_1000099659

Sequences

Sequence LengthMass (Da)Tools
B3GXD4 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 6F96F8055D1DE572

FASTA43246,908
        10         20         30         40         50         60 
MEKITLAPIS RVEGEINLPG SKSLSNRALL LAALAKGTTK VTNLLDSDDI RHMLNALKAL 

        70         80         90        100        110        120 
GVNYSLSEDK TVCTVEGVGG AFNWKNGLAL FLGNAGTAMR PLTAALCLKG ATEAEVVLTG 

       130        140        150        160        170        180 
EPRMKERPIK HLVDALRQAG ASVQYLENEG YPPVAIRNSG LKGGKVQIDG SISSQFLTAL 

       190        200        210        220        230        240 
LMAAPLAEGD MEIEIIGELV SKPYIDITLA MMKDFGVKVE NRNYQTFVVK GNQSYLSPEK 

       250        260        270        280        290        300 
YLVEGDASSA SYFLAAGAIK GKVKVTGIGK NSIQGDRLFA NVLEAMGAKI TWGDDFIQAE 

       310        320        330        340        350        360 
QGKLKGVDMD MNHIPDAAMT IATAALFAEG ETVIRNIYNW RVKETDRLTA MATELRKVGA 

       370        380        390        400        410        420 
TVEEGEDFIR IQPLPLTQFQ HAEIATYNDH RMAMCFSLIA LSDTPVTILD PKCTAKTFPT 

       430 
YFTEFEKLSE RT

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References

[1]"Genome and proteome analysis of A. pleuropneumoniae serotype 7."
Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AP76.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001091 Genomic DNA. Translation: ACE61393.1.
RefSeqYP_001968535.1. NC_010939.1.

3D structure databases

ProteinModelPortalB3GXD4.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3GXD4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6396148.
GenomeReviewsGene locus APP7_0741 in contig CP001091_GR.
KEGGapa:APP7_0741.
PATRIC20755103. VBIActPle116979_0762.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG646626.
OMAGADIEWG.
ProtClustDBPRK02427.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_ACTP7
AccessionPrimary (citable) accession number: B3GXD4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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