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B3GX43

- FTHS_ACTP7

UniProt

B3GX43 - FTHS_ACTP7

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPLE537457:GJI0-556-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:APP7_0543
OrganismiActinobacillus pleuropneumoniae serotype 7 (strain AP76)
Taxonomic identifieri537457 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
ProteomesiUP000001226: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000146670Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi537457.APP7_0543.

Structurei

3D structure databases

ProteinModelPortaliB3GX43.
SMRiB3GX43. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCIMHAGP.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3GX43-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDVEIAQA ATMQPIHKIA EKLGLNADQI EQYGKYKAKI NPTDAFKLPA
60 70 80 90 100
KNGKLILVTA INPTPAGEGK TTVTIGLTDA LNQLGKNAVV AAREPSLGPV
110 120 130 140 150
FGVKGGAAGG GYAQVLPMED INLHFTGDFH AITSANNLLA ALLDNHIYQG
160 170 180 190 200
NALNIDTKRV LWRRVIDMND RQLRNVLGGL GNPTDGVIRP DGFDITVASE
210 220 230 240 250
VMAIFCLAKD LADLKTRLGN ILVAYTKDKQ PVYAKDLNAH GAMAALLKDA
260 270 280 290 300
IKPNLVQTIE GSPAFIHGGP FANIAHGCNS VTATRLALHL GDYAVTEAGF
310 320 330 340 350
GADLGAEKFC DIKCRLADLK PDVAVVVATV KALKYNGGVE KANLAEENLT
360 370 380 390 400
ALQQGLPNLL KHISNLKNVF GLPVVVALNR FVSDTDAELA LIQTACAKQG
410 420 430 440 450
VEVSLTEVWG KGGAGGVDLA QKVLKAIDEQ ENRFNFVYDV NESVQNKIKA
460 470 480 490 500
IAQKIYGADD VNFSAEALAE IKNLEKLGLD KLPICMAKTQ YSLSDNAKLL
510 520 530 540 550
GCPSGFTVTV RSISVSAGAG FIVAICGSIM RMPGLPKVPA ANRIDVDENG

LITGLF
Length:556
Mass (Da):58,955
Last modified:July 22, 2008 - v1
Checksum:iAD5278FBF34F08E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001091 Genomic DNA. Translation: ACE61195.1.
RefSeqiYP_001968337.1. NC_010939.1.

Genome annotation databases

EnsemblBacteriaiACE61195; ACE61195; APP7_0543.
GeneIDi6396558.
KEGGiapa:APP7_0543.
PATRICi20754691. VBIActPle116979_0558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001091 Genomic DNA. Translation: ACE61195.1 .
RefSeqi YP_001968337.1. NC_010939.1.

3D structure databases

ProteinModelPortali B3GX43.
SMRi B3GX43. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 537457.APP7_0543.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE61195 ; ACE61195 ; APP7_0543 .
GeneIDi 6396558.
KEGGi apa:APP7_0543.
PATRICi 20754691. VBIActPle116979_0558.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi CIMHAGP.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci APLE537457:GJI0-556-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome and proteome analysis of A. pleuropneumoniae serotype 7."
    Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AP76.

Entry informationi

Entry nameiFTHS_ACTP7
AccessioniPrimary (citable) accession number: B3GX43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: October 1, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3