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B3GX43 (FTHS_ACTP7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:APP7_0543
OrganismActinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP]
Taxonomic identifier537457 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000146670

Regions

Nucleotide binding64 – 718ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B3GX43 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: AD5278FBF34F08E5

FASTA55658,955
        10         20         30         40         50         60 
MKSDVEIAQA ATMQPIHKIA EKLGLNADQI EQYGKYKAKI NPTDAFKLPA KNGKLILVTA 

        70         80         90        100        110        120 
INPTPAGEGK TTVTIGLTDA LNQLGKNAVV AAREPSLGPV FGVKGGAAGG GYAQVLPMED 

       130        140        150        160        170        180 
INLHFTGDFH AITSANNLLA ALLDNHIYQG NALNIDTKRV LWRRVIDMND RQLRNVLGGL 

       190        200        210        220        230        240 
GNPTDGVIRP DGFDITVASE VMAIFCLAKD LADLKTRLGN ILVAYTKDKQ PVYAKDLNAH 

       250        260        270        280        290        300 
GAMAALLKDA IKPNLVQTIE GSPAFIHGGP FANIAHGCNS VTATRLALHL GDYAVTEAGF 

       310        320        330        340        350        360 
GADLGAEKFC DIKCRLADLK PDVAVVVATV KALKYNGGVE KANLAEENLT ALQQGLPNLL 

       370        380        390        400        410        420 
KHISNLKNVF GLPVVVALNR FVSDTDAELA LIQTACAKQG VEVSLTEVWG KGGAGGVDLA 

       430        440        450        460        470        480 
QKVLKAIDEQ ENRFNFVYDV NESVQNKIKA IAQKIYGADD VNFSAEALAE IKNLEKLGLD 

       490        500        510        520        530        540 
KLPICMAKTQ YSLSDNAKLL GCPSGFTVTV RSISVSAGAG FIVAICGSIM RMPGLPKVPA 

       550 
ANRIDVDENG LITGLF 

« Hide

References

[1]"Genome and proteome analysis of A. pleuropneumoniae serotype 7."
Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AP76.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001091 Genomic DNA. Translation: ACE61195.1.
RefSeqYP_001968337.1. NC_010939.1.

3D structure databases

ProteinModelPortalB3GX43.
SMRB3GX43. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING537457.APP7_0543.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACE61195; ACE61195; APP7_0543.
GeneID6396558.
KEGGapa:APP7_0543.
PATRIC20754691. VBIActPle116979_0558.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACIMHAGP.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycAPLE537457:GJI0-556-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_ACTP7
AccessionPrimary (citable) accession number: B3GX43
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways