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Protein
Submitted name:

Protein tyrosine phosphatase-2

Gene

PTPN11

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiB3GUD4.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase-2Imported
Gene namesi
Name:PTPN11Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiB3GUD4.
PeptideAtlasiB3GUD4.

Expressioni

Gene expression databases

BgeeiB3GUD4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340944.

Structurei

3D structure databases

ProteinModelPortaliB3GUD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 9997SH2InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0790. Eukaryota.
COG5599. LUCA.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B3GUD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RRWFHPNITG VEAENLLLTR GVDGSFLARP SKSNPGDFTL SVRRNGAVTH
60 70 80 90 100
IKIQNTGDYY DLYGGEKFAT LAELVQYYME HHGQLKEKNG DVIELKYPLN

CA
Length:102
Mass (Da):11,556
Last modified:July 22, 2008 - v1
Checksum:iD081835A1FC63B19
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei102 – 1021Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU779707 mRNA. Translation: ACE60555.1.
UniGeneiHs.506852.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU779707 mRNA. Translation: ACE60555.1.
UniGeneiHs.506852.

3D structure databases

ProteinModelPortaliB3GUD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340944.

Proteomic databases

PaxDbiB3GUD4.
PeptideAtlasiB3GUD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0790. Eukaryota.
COG5599. LUCA.

Enzyme and pathway databases

SignaLinkiB3GUD4.

Miscellaneous databases

ChiTaRSiPTPN11. human.

Gene expression databases

BgeeiB3GUD4.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression and purification of 15N-labeled 2-SH2 protein domain of SHP-2 from Homo sapiens in Escherichia coli for NMR studies and applications."
    Wu Y., Guo J.F.
    Int. J. Biol. Macromol. 45:1-7(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB3GUD4_HUMAN
AccessioniPrimary (citable) accession number: B3GUD4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 6, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.