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Protein
Submitted name:

Protein tyrosine phosphatase-2

Gene

PTPN11

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiB3GUD4.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase-2Imported
Gene namesi
Name:PTPN11Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiB3GUD4.
PeptideAtlasiB3GUD4.

Expressioni

Gene expression databases

BgeeiENSG00000179295.

Structurei

3D structure databases

ProteinModelPortaliB3GUD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 99SH2InterPro annotationAdd BLAST97

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0790. Eukaryota.
COG5599. LUCA.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR000980. SH2.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Fragment.

B3GUD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RRWFHPNITG VEAENLLLTR GVDGSFLARP SKSNPGDFTL SVRRNGAVTH
60 70 80 90 100
IKIQNTGDYY DLYGGEKFAT LAELVQYYME HHGQLKEKNG DVIELKYPLN

CA
Length:102
Mass (Da):11,556
Last modified:July 22, 2008 - v1
Checksum:iD081835A1FC63B19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei102Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU779707 mRNA. Translation: ACE60555.1.
UniGeneiHs.506852.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB3GUD4_HUMAN
AccessioniPrimary (citable) accession number: B3GUD4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 5, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.