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Protein
Submitted name:

TNF-alpha

Gene

TNFa

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TNF-alphaImported
Submitted name:
Tumor necrosis factor alphaImported
Gene namesi
Name:TNFaImported
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, SecretedSAAS annotation

Expressioni

Gene expression databases

GenevisibleiB3GDZ6. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001491.

Structurei

3D structure databases

ProteinModelPortaliB3GDZ6.
SMRiB3GDZ6. Positions 84-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG012516.
KOiK03156.
OMAiPWYEPIY.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3GDZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTESMIRDV ELAEEALAKK AGGPQGSRRC LCLSLFSFLL VAGATTLFCL
60 70 80 90 100
LHFEVIGPQK EEFPAGPLSI NPLAQGLRSS SQTSDKPVAH VVANVKAEGQ
110 120 130 140 150
LQWQSGYANA LLANGVKLKD NQLVVPTDGL YLIYSQVLFR GQGCPSTNVF
160 170 180 190 200
LTHTISRIAV SYQTKVNLLS AIKSPCQRET PEGAEAKPWY EPIYLGGVFQ
210 220 230
LEKDDRLSAE INLPDYLDFA ESGQVYFGII AL
Length:232
Mass (Da):25,254
Last modified:July 22, 2008 - v1
Checksum:i65B28F702D99C8BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU682384 mRNA. Translation: ACD81655.1.
JF831365 mRNA. Translation: AEP25618.1.
RefSeqiNP_999187.1. NM_214022.1.
UniGeneiSsc.100.

Genome annotation databases

GeneIDi397086.
KEGGissc:397086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU682384 mRNA. Translation: ACD81655.1.
JF831365 mRNA. Translation: AEP25618.1.
RefSeqiNP_999187.1. NM_214022.1.
UniGeneiSsc.100.

3D structure databases

ProteinModelPortaliB3GDZ6.
SMRiB3GDZ6. Positions 84-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397086.
KEGGissc:397086.

Organism-specific databases

CTDi7124.

Phylogenomic databases

HOVERGENiHBG012516.
KOiK03156.
OMAiPWYEPIY.

Gene expression databases

GenevisibleiB3GDZ6. SS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "U.S. Veterinary Immune Reagent Network: Expressed Swine Gene Sequences."
    Boyd P., Tompkins D., Hudgens T., Baldwin C., Lunney J.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PBMCImported.
  2. "cDNA Cloning, Sequence Analysis and Tissue Expression Profile of TNF-alpha in Banna Mini-pig Inbred Line (BMI)."
    Huo J.L., Zhao Y., Zeng Y.Z.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB3GDZ6_PIG
AccessioniPrimary (citable) accession number: B3GDZ6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: June 24, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.