B3GDZ6 (B3GDZ6_PIG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
TNF-alpha EMBL AEP25618.1

Submitted name:
Tumor necrosis factor alpha EMBL ACD81655.1

Gene names

Name:

TNFa EMBL ACD81655.1

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Cellular component	Membrane SAAS SAAS006052 Secreted SAAS SAAS006053
Molecular function	Cytokine SAAS SAAS006052
Gene Ontology (GO)
Biological_process	JNK cascade Inferred from electronic annotation. Source: Compara activation of MAPK activity Inferred from electronic annotation. Source: Compara activation of MAPKKK activity Inferred from electronic annotation. Source: Compara activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara activation of necroptosis by extracellular signals Inferred from electronic annotation. Source: Compara cellular response to amino acid stimulus Inferred from electronic annotation. Source: Compara cellular response to nicotine Inferred from electronic annotation. Source: Compara chronic inflammatory response to antigenic stimulus Inferred from electronic annotation. Source: Compara defense response to Gram-positive bacterium Inferred from electronic annotation. Source: Compara embryonic digestive tract development Inferred from electronic annotation. Source: Compara epithelial cell proliferation involved in salivary gland morphogenesis Inferred from electronic annotation. Source: Compara extracellular matrix organization Inferred from electronic annotation. Source: Compara extrinsic apoptotic signaling pathway via death domain receptors Inferred from electronic annotation. Source: Compara glucose metabolic process Inferred from electronic annotation. Source: Compara humoral immune response Inferred from electronic annotation. Source: Compara induction of apoptosis Inferred from electronic annotation. Source: Compara leukocyte tethering or rolling Inferred from electronic annotation. Source: Compara lipopolysaccharide-mediated signaling pathway Inferred from electronic annotation. Source: Compara necrotic cell death Inferred from electronic annotation. Source: Compara negative regulation of alkaline phosphatase activity Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of branching involved in lung morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of cytokine secretion involved in immune response Inferred from electronic annotation. Source: Compara negative regulation of glucose import Inferred from electronic annotation. Source: Compara negative regulation of growth of symbiont in host Inferred from electronic annotation. Source: Compara negative regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara negative regulation of lipid catabolic process Inferred from electronic annotation. Source: Compara negative regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara negative regulation of viral genome replication Inferred from electronic annotation. Source: Compara organ morphogenesis Inferred from electronic annotation. Source: Compara osteoclast differentiation Inferred from electronic annotation. Source: Compara positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara positive regulation of JNK cascade Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of NFAT protein import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of calcidiol 1-monooxygenase activity Inferred from electronic annotation. Source: Compara positive regulation of chemokine (C-X-C motif) ligand 2 production Inferred from electronic annotation. Source: Compara positive regulation of chemokine biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of chronic inflammatory response to antigenic stimulus Inferred from electronic annotation. Source: Compara positive regulation of cytokine secretion Inferred from electronic annotation. Source: Compara positive regulation of fever generation Inferred from electronic annotation. Source: Compara positive regulation of hair follicle development Inferred from electronic annotation. Source: Compara positive regulation of heterotypic cell-cell adhesion Inferred from electronic annotation. Source: Compara positive regulation of humoral immune response mediated by circulating immunoglobulin Inferred from electronic annotation. Source: Compara positive regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-8 biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of membrane protein ectodomain proteolysis Inferred from electronic annotation. Source: Compara positive regulation of nitric oxide biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of osteoclast differentiation Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of podosome assembly Inferred from electronic annotation. Source: Compara positive regulation of protein complex disassembly Inferred from electronic annotation. Source: Compara positive regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of protein localization to cell surface Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of translational initiation by iron Inferred from electronic annotation. Source: Compara positive regulation of vitamin D biosynthetic process Inferred from electronic annotation. Source: Compara protein import into nucleus, translocation Inferred from electronic annotation. Source: Compara protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara receptor biosynthetic process Inferred from electronic annotation. Source: Compara regulation of branching involved in salivary gland morphogenesis Inferred from electronic annotation. Source: Compara regulation of immunoglobulin secretion Inferred from electronic annotation. Source: Compara regulation of insulin secretion Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to virus Inferred from electronic annotation. Source: Compara sequestering of triglyceride Inferred from electronic annotation. Source: Compara transformed cell apoptotic process Inferred from electronic annotation. Source: Compara tumor necrosis factor-mediated signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Inferred from electronic annotation. Source: Compara membrane raft Inferred from electronic annotation. Source: Compara phagocytic cup Inferred from electronic annotation. Source: Compara recycling endosome Inferred from electronic annotation. Source: Compara
Molecular_function	transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3GDZ6 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 65B28F702D99C8BE	FASTA	232	25,254
	10 20 30 40 50 60 MSTESMIRDV ELAEEALAKK AGGPQGSRRC LCLSLFSFLL VAGATTLFCL LHFEVIGPQK 70 80 90 100 110 120 EEFPAGPLSI NPLAQGLRSS SQTSDKPVAH VVANVKAEGQ LQWQSGYANA LLANGVKLKD 130 140 150 160 170 180 NQLVVPTDGL YLIYSQVLFR GQGCPSTNVF LTHTISRIAV SYQTKVNLLS AIKSPCQRET 190 200 210 220 230 PEGAEAKPWY EPIYLGGVFQ LEKDDRLSAE INLPDYLDFA ESGQVYFGII AL

References

[1]	"U.S. Veterinary Immune Reagent Network: Expressed Swine Gene Sequences." Boyd P., Tompkins D., Hudgens T., Baldwin C., Lunney J. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: PBMC EMBL ACD81655.1.
[2]	"cDNA Cloning, Sequence Analysis and Tissue Expression Profile of TNF-alpha in Banna Mini-pig Inbred Line (BMI)." Huo J.L., Zhao Y., Zeng Y.Z. Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU682384 mRNA. Translation: ACD81655.1. JF831365 mRNA. Translation: AEP25618.1.
RefSeq	NP_999187.1. NM_214022.1.
UniGene	Ssc.100.
3D structure databases
ProteinModelPortal	B3GDZ6.
SMR	B3GDZ6. Positions 84-232.
ModBase	Search...
Protein-protein interaction databases
STRING	B3GDZ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397086.
KEGG	ssc:397086.
Organism-specific databases
CTD	7124.
Phylogenomic databases
HOVERGEN	HBG012516.
KO	K03156.
OMA	WYEPIYL.
Gene expression databases
ArrayExpress	B3GDZ6.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR006052. TNF. IPR006053. TNF_a/b/c. IPR002959. TNF_alpha. IPR021184. TNF_CS. IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
Pfam	PF00229. TNF. 1 hit. [Graphical view]
PRINTS	PR01234. TNECROSISFCT. PR01235. TNFALPHA.
SMART	SM00207. TNF. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS00251. TNF_1. 1 hit. PS50049. TNF_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B3GDZ6_PIG

Accession

Primary (citable) accession number: B3GDZ6

Entry history

Integrated into UniProtKB/TrEMBL:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	April 3, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)