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B3F211 (IBP2B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor-binding protein 2-B

Short name=IGF-binding protein 2-B
Short name=IGFBP-2-B
Short name=IGFBP-2b
Gene names
Name:igfbp2b
Synonyms:igfbp2a
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Ref.1

Subunit structure

Interacts with igf2 By similarity. Interacts with igf1. Ref.1 UniProtKB Q9PTH3

Subcellular location

Secreted Potential.

Tissue specificity

In early embryos, expressed at a low level in most tissues with expression becoming abundant in the liver by 96 hours post-fertilization (hpf). The expression pattern in adults exhibits sexual dimorphism; in adult males expression is limited exclusively to the liver whereas in adult females expression is observed in the liver and other tissues including the gut, kidney, ovary and muscle. Ref.1

Developmental stage

Expressed throughout embryogenesis. Ref.1

Sequence similarities

Contains 1 IGFBP N-terminal domain.

Contains 1 thyroglobulin type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 265248Insulin-like growth factor-binding protein 2-B UniProtKB Q9PTH3
PRO_0000381735

Regions

Domain19 – 9981IGFBP N-terminal
Domain166 – 24883Thyroglobulin type-1
Motif243 – 2453Cell attachment site Potential

Amino acid modifications

Disulfide bond169 ↔ 203 By similarity UniProtKB P18065
Disulfide bond214 ↔ 225 By similarity UniProtKB P18065
Disulfide bond227 ↔ 248 By similarity UniProtKB P18065

Sequences

Sequence LengthMass (Da)Tools
B3F211 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 1E1A785AB69D92DE

FASTA26529,439
        10         20         30         40         50         60 
MSLALLCSLL LVHGSLGEIV FRCPSCTAER QAACPKLTTS CEIVREPGCG CCPVCARQKG 

        70         80         90        100        110        120 
ELCGVYTTRC GSGLRCYPSA NSELPLEQLI QGLGRCENKV DLEPTMTNQE SAAHSGEVNG 

       130        140        150        160        170        180 
TRSPPMKKPG KDYQYIKEIA VNKHHNNKRT RMYNTQDDPK TPHPKQSQCQ QELDKVLENI 

       190        200        210        220        230        240 
SRMAFHDNKG PLENLYDLKF PNCDKTGQYN LKQCHMSTHG QRGECWCVNP YTGVQIPSSD 

       250        260 
KVRGDPNCSQ YYGGPELEPP TAQQK 

« Hide

References

[1]"Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence."
Zhou J., Li W., Kamei H., Duan C.
PLoS ONE 3:E3926-E3926(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IGF1, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF507265 mRNA. Translation: ABS30427.1.
UniGeneDr.111469.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000019643.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ZFINZDB-GENE-090107-3. igfbp2b.

Phylogenomic databases

eggNOGNOG47500.
HOGENOMHOG000253012.
PhylomeDBB3F211.

Family and domain databases

Gene3D4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
PfamPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIBP2B_DANRE
AccessionPrimary (citable) accession number: B3F211
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: July 22, 2008
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families