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B3F211

- IBP2B_DANRE

UniProt

B3F211 - IBP2B_DANRE

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Protein

Insulin-like growth factor-binding protein 2-B

Gene

igfbp2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.1 Publication

GO - Molecular functioni

  1. insulin-like growth factor I binding Source: UniProtKB
  2. insulin-like growth factor II binding Source: UniProtKB

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. negative regulation of cell proliferation Source: UniProtKB
  3. negative regulation of developmental growth Source: UniProtKB
  4. negative regulation of DNA replication Source: UniProtKB
  5. regulation of cell growth Source: InterPro
  6. regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

Growth factor binding

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2-B
Short name:
IGF-binding protein 2-B
Short name:
IGFBP-2-B
Short name:
IGFBP-2b
Gene namesi
Name:igfbp2bImported
Synonyms:igfbp2aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-090107-3. igfbp2b.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 265248Insulin-like growth factor-binding protein 2-BBy similarityCuratedPRO_0000381735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi169 ↔ 203By similarityPROSITE-ProRule annotation
Disulfide bondi214 ↔ 225By similarityPROSITE-ProRule annotation
Disulfide bondi227 ↔ 248By similarityPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

In early embryos, expressed at a low level in most tissues with expression becoming abundant in the liver by 96 hours post-fertilization (hpf). The expression pattern in adults exhibits sexual dimorphism; in adult males expression is limited exclusively to the liver whereas in adult females expression is observed in the liver and other tissues including the gut, kidney, ovary and muscle.1 Publication

Developmental stagei

Expressed throughout embryogenesis.1 Publication

Interactioni

Subunit structurei

Interacts with igf2 (By similarity). Interacts with igf1.By similarity1 Publication

Protein-protein interaction databases

STRINGi7955.ENSDARP00000019643.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 9981IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini166 – 24883Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi243 – 2453Cell attachment siteSequence Analysis

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47500.
HOGENOMiHOG000253012.
InParanoidiB3F211.
PhylomeDBiB3F211.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3F211-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLALLCSLL LVHGSLGEIV FRCPSCTAER QAACPKLTTS CEIVREPGCG
60 70 80 90 100
CCPVCARQKG ELCGVYTTRC GSGLRCYPSA NSELPLEQLI QGLGRCENKV
110 120 130 140 150
DLEPTMTNQE SAAHSGEVNG TRSPPMKKPG KDYQYIKEIA VNKHHNNKRT
160 170 180 190 200
RMYNTQDDPK TPHPKQSQCQ QELDKVLENI SRMAFHDNKG PLENLYDLKF
210 220 230 240 250
PNCDKTGQYN LKQCHMSTHG QRGECWCVNP YTGVQIPSSD KVRGDPNCSQ
260
YYGGPELEPP TAQQK
Length:265
Mass (Da):29,439
Last modified:July 22, 2008 - v1
Checksum:i1E1A785AB69D92DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF507265 mRNA. Translation: ABS30427.1.
UniGeneiDr.111469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF507265 mRNA. Translation: ABS30427.1 .
UniGenei Dr.111469.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000019643.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ZFINi ZDB-GENE-090107-3. igfbp2b.

Phylogenomic databases

eggNOGi NOG47500.
HOGENOMi HOG000253012.
InParanoidi B3F211.
PhylomeDBi B3F211.

Family and domain databases

Gene3Di 4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view ]
PANTHERi PTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
Pfami PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
PRINTSi PR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTi SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEi PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence."
    Zhou J., Li W., Kamei H., Duan C.
    PLoS ONE 3:E3926-E3926(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IGF1, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiIBP2B_DANRE
AccessioniPrimary (citable) accession number: B3F211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3