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B3F211

- IBP2B_DANRE

UniProt

B3F211 - IBP2B_DANRE

Protein

Insulin-like growth factor-binding protein 2-B

Gene

igfbp2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.1 Publication

    GO - Molecular functioni

    1. insulin-like growth factor I binding Source: UniProtKB
    2. insulin-like growth factor II binding Source: UniProtKB

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. negative regulation of cell proliferation Source: UniProtKB
    3. negative regulation of developmental growth Source: UniProtKB
    4. negative regulation of DNA replication Source: UniProtKB
    5. regulation of cell growth Source: InterPro
    6. regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Growth regulation

    Keywords - Ligandi

    Growth factor binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 2-B
    Short name:
    IGF-binding protein 2-B
    Short name:
    IGFBP-2-B
    Short name:
    IGFBP-2b
    Gene namesi
    Name:igfbp2bImported
    Synonyms:igfbp2aImported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-090107-3. igfbp2b.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 265248Insulin-like growth factor-binding protein 2-BBy similarityCuratedPRO_0000381735Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi169 ↔ 203By similarityPROSITE-ProRule annotation
    Disulfide bondi214 ↔ 225By similarityPROSITE-ProRule annotation
    Disulfide bondi227 ↔ 248By similarityPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    In early embryos, expressed at a low level in most tissues with expression becoming abundant in the liver by 96 hours post-fertilization (hpf). The expression pattern in adults exhibits sexual dimorphism; in adult males expression is limited exclusively to the liver whereas in adult females expression is observed in the liver and other tissues including the gut, kidney, ovary and muscle.1 Publication

    Developmental stagei

    Expressed throughout embryogenesis.1 Publication

    Interactioni

    Subunit structurei

    Interacts with igf2 By similarity. Interacts with igf1.By similarity1 Publication

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000019643.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 9981IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini166 – 24883Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi243 – 2453Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47500.
    HOGENOMiHOG000253012.
    PhylomeDBiB3F211.

    Family and domain databases

    Gene3Di4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR012210. IGFBP-2.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF5. PTHR11551:SF5. 1 hit.
    PfamiPF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    PRINTSiPR01976. IGFBPFAMILY.
    PR01978. IGFBPFAMILY2.
    SMARTiSM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B3F211-1 [UniParc]FASTAAdd to Basket

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    MSLALLCSLL LVHGSLGEIV FRCPSCTAER QAACPKLTTS CEIVREPGCG    50
    CCPVCARQKG ELCGVYTTRC GSGLRCYPSA NSELPLEQLI QGLGRCENKV 100
    DLEPTMTNQE SAAHSGEVNG TRSPPMKKPG KDYQYIKEIA VNKHHNNKRT 150
    RMYNTQDDPK TPHPKQSQCQ QELDKVLENI SRMAFHDNKG PLENLYDLKF 200
    PNCDKTGQYN LKQCHMSTHG QRGECWCVNP YTGVQIPSSD KVRGDPNCSQ 250
    YYGGPELEPP TAQQK 265
    Length:265
    Mass (Da):29,439
    Last modified:July 22, 2008 - v1
    Checksum:i1E1A785AB69D92DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF507265 mRNA. Translation: ABS30427.1.
    UniGeneiDr.111469.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF507265 mRNA. Translation: ABS30427.1 .
    UniGenei Dr.111469.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000019643.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ZFINi ZDB-GENE-090107-3. igfbp2b.

    Phylogenomic databases

    eggNOGi NOG47500.
    HOGENOMi HOG000253012.
    PhylomeDBi B3F211.

    Family and domain databases

    Gene3Di 4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR012210. IGFBP-2.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF5. PTHR11551:SF5. 1 hit.
    Pfami PF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01976. IGFBPFAMILY.
    PR01978. IGFBPFAMILY2.
    SMARTi SM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence."
      Zhou J., Li W., Kamei H., Duan C.
      PLoS ONE 3:E3926-E3926(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IGF1, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiIBP2B_DANRE
    AccessioniPrimary (citable) accession number: B3F211
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3