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B3EY95

- B3EY95_ACEAC

UniProt

B3EY95 - B3EY95_ACEAC

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Protein
Submitted name: Succinyl-CoA:acetate CoA-transferase
Gene
aarC
Organism
Acetobacter aceti
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei6 – 61Sulfate 2
Binding sitei11 – 111Sulfate 3
Binding sitei11 – 111Sulfate 4
Binding sitei101 – 1011Sulfate 5
Binding sitei141 – 1411Sulfate 2; via amide nitrogen
Binding sitei171 – 1711Sulfate 6
Binding sitei175 – 1751Sulfate 7
Binding sitei200 – 2001Sulfate 8
Binding sitei226 – 2261Sulfate 6
Binding sitei294 – 2941Coenzyme A (covalent)
Binding sitei335 – 3351Sulfate 7
Binding sitei408 – 4081Sulfate 11; via amide nitrogen
Binding sitei463 – 4631Sulfate 12

GO - Molecular functioni

  1. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17982.

Names & Taxonomyi

Protein namesi
Submitted name:
Succinyl-CoA:acetate CoA-transferaseImported
Submitted name:
Succinyl-CoA:acetate coenzyme A transferaseImported
Gene namesi
Name:aarCImported
OrganismiAcetobacter acetiImported
Taxonomic identifieri435 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcetobacterAcetobacter subgen. Acetobacter

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei294 – 2941N-actyl XImported

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EU3X-ray1.58A/B1-505[»]
4EU4X-ray2.80A/B1-505[»]
4EU5X-ray1.74A/B1-505[»]
4EU6X-ray1.99A/B1-505[»]
4EU7X-ray1.70A/B1-505[»]
4EU8X-ray1.81A/B1-505[»]
4EU9X-ray1.48A/B1-505[»]
4EUAX-ray2.40A/B1-505[»]
4EUBX-ray1.97A/B1-505[»]
4EUCX-ray2.64A/B1-505[»]
4EUDX-ray1.95A/B1-505[»]
4FACX-ray2.05A/B1-505[»]

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 43Sulfate 1 binding
Regioni256 – 2583Sulfate 9 binding
Regioni408 – 4092Sulfate 10 binding

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
IPR017821. Succinate_CoA_transferase.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03458. YgfH_subfam. 1 hit.

Sequencei

Sequence statusi: Complete.

B3EY95-1 [UniParc]FASTAAdd to Basket

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MTERIRNVAL RSKVCPAETA SELIKHGDVV GTSGFTGAGY PKEVPKALAQ    50
RMEAAHDRGE KYQISLITGA STGPQLDGEL AKANGVYFRS PFNTDATMRN 100
RINAGETEYF DNHLGQVAGR AVQGNYGKFN IALVEATAIT EDGGIVPTSS 150
VGNSQTFLNL AEKVIIEVNE WQNPMLEGIH DIWDGNVSGV PTRDIVPIVR 200
ADQRVGGPVL RVNPDKIAAI VRTNDRDRNA PFAAPDETAK AIAGYLLDFF 250
GHEVKQNRLP PSLLPLQSGV GNVANAVLEG LKEGPFENLV GYSEVIQDGM 300
LAMLDSGRMR IASASSFSLS PEAAEEINNR MDFFRSKIIL RQQDVSNSPG 350
IIRRLGCIAM NGMIEADIYG NVNSTRVMGS KMMNGIGGSG DFARSSYLSI 400
FLSPSTAKGG KISAIVPMAA HVDHIMQDAQ IFVTEQGLAD LRGLSPVQRA 450
REIISKCAHP DYRPMLQDYF DRALKNSFGK HTPHLLTEAL SWHQRFIDTG 500
TMLPS 505
Length:505
Mass (Da):54,826
Last modified:July 22, 2008 - v1
Checksum:iC02A8779588D2510
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ631551 Genomic DNA. Translation: ACD85596.1.
JX475924 Genomic DNA. Translation: AGG68319.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ631551 Genomic DNA. Translation: ACD85596.1 .
JX475924 Genomic DNA. Translation: AGG68319.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4EU3 X-ray 1.58 A/B 1-505 [» ]
4EU4 X-ray 2.80 A/B 1-505 [» ]
4EU5 X-ray 1.74 A/B 1-505 [» ]
4EU6 X-ray 1.99 A/B 1-505 [» ]
4EU7 X-ray 1.70 A/B 1-505 [» ]
4EU8 X-ray 1.81 A/B 1-505 [» ]
4EU9 X-ray 1.48 A/B 1-505 [» ]
4EUA X-ray 2.40 A/B 1-505 [» ]
4EUB X-ray 1.97 A/B 1-505 [» ]
4EUC X-ray 2.64 A/B 1-505 [» ]
4EUD X-ray 1.95 A/B 1-505 [» ]
4FAC X-ray 2.05 A/B 1-505 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-17982.

Family and domain databases

InterProi IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
IPR017821. Succinate_CoA_transferase.
[Graphical view ]
Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03458. YgfH_subfam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Structure of a NADH-insensitive hexameric citrate synthase that resists acid inactivation."
    Francois J.A., Starks C.M., Sivanuntakorn S., Jiang H., Ransome A.E., Nam J.W., Constantine C.Z., Kappock T.J.
    Biochemistry 45:13487-13499(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 10-8Imported and 1023Imported.
  2. "A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti."
    Mullins E.A., Francois J.A., Kappock T.J.
    J. Bacteriol. 190:4933-4940(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 10-8Imported and 1023Imported.
  3. Kappock T.J.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 1023Imported.
  4. "Crystal structures of Acetobacter aceti succinyl-coenzyme A (CoA):acetate CoA-transferase reveal specificity determinants and illustrate the mechanism used by class I CoA-transferases."
    Mullins E.A., Kappock T.J.
    Biochemistry 51:8422-8434(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) IN COMPLEX WITH COENZYME A.
  5. "Succinyl-CoA:acetate CoA-transferase from Acetobacter aceti."
    Mullins E.A., Kappock T.J.
    Submitted (MAY-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS), N-ACTYL X AT GLU-294.
  6. "Functional analysis of the acetic acid resistance (aar) gene cluster in Acetobacter aceti strain 1023."
    Mullins E.A., Kappock T.J.
    Acetic Acid Bacteria 2:e3-e3(2013)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 10-8Imported.

Entry informationi

Entry nameiB3EY95_ACEAC
AccessioniPrimary (citable) accession number: B3EY95
Entry historyi
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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