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B3EY95

- B3EY95_ACEAC

UniProt

B3EY95 - B3EY95_ACEAC

Protein
Submitted name:

Succinyl-CoA:acetate CoA-transferase

Gene

aarC

Organism
Acetobacter aceti
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei6 – 61Sulfate 2
    Binding sitei11 – 111Sulfate 3
    Binding sitei11 – 111Sulfate 4
    Binding sitei101 – 1011Sulfate 5
    Binding sitei141 – 1411Sulfate 2; via amide nitrogen
    Binding sitei171 – 1711Sulfate 6
    Binding sitei175 – 1751Sulfate 7
    Binding sitei200 – 2001Sulfate 8
    Binding sitei226 – 2261Sulfate 6
    Binding sitei294 – 2941Coenzyme A (covalent)
    Binding sitei294 – 2941CoenzymeA (covalent)Imported
    Binding sitei335 – 3351Sulfate 7
    Binding sitei408 – 4081Sulfate 11; via amide nitrogen
    Binding sitei463 – 4631Sulfate 12

    GO - Molecular functioni

    1. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. acetyl-CoA metabolic process Source: InterPro

    Keywords - Molecular functioni

    TransferaseImported

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17982.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Succinyl-CoA:acetate CoA-transferaseImported
    Submitted name:
    Succinyl-CoA:acetate coenzyme A transferaseImported
    Gene namesi
    Name:aarCImported
    OrganismiAcetobacter acetiImported
    Taxonomic identifieri435 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcetobacterAcetobacter subgen. Acetobacter

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4EU3X-ray1.58A/B1-505[»]
    4EU4X-ray2.80A/B1-505[»]
    4EU5X-ray1.74A/B1-505[»]
    4EU6X-ray1.99A/B1-505[»]
    4EU7X-ray1.70A/B1-505[»]
    4EU8X-ray1.81A/B1-505[»]
    4EU9X-ray1.48A/B1-505[»]
    4EUAX-ray2.40A/B1-505[»]
    4EUBX-ray1.97A/B1-505[»]
    4EUCX-ray2.64A/B1-505[»]
    4EUDX-ray1.95A/B1-505[»]
    4FACX-ray2.05A/B1-505[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 43Sulfate 1 binding
    Regioni256 – 2583Sulfate 9 binding
    Regioni408 – 4092Sulfate 10 binding

    Family and domain databases

    InterProiIPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    IPR017821. Succinate_CoA_transferase.
    [Graphical view]
    PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03458. YgfH_subfam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3EY95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTERIRNVAL RSKVCPAETA SELIKHGDVV GTSGFTGAGY PKEVPKALAQ    50
    RMEAAHDRGE KYQISLITGA STGPQLDGEL AKANGVYFRS PFNTDATMRN 100
    RINAGETEYF DNHLGQVAGR AVQGNYGKFN IALVEATAIT EDGGIVPTSS 150
    VGNSQTFLNL AEKVIIEVNE WQNPMLEGIH DIWDGNVSGV PTRDIVPIVR 200
    ADQRVGGPVL RVNPDKIAAI VRTNDRDRNA PFAAPDETAK AIAGYLLDFF 250
    GHEVKQNRLP PSLLPLQSGV GNVANAVLEG LKEGPFENLV GYSEVIQDGM 300
    LAMLDSGRMR IASASSFSLS PEAAEEINNR MDFFRSKIIL RQQDVSNSPG 350
    IIRRLGCIAM NGMIEADIYG NVNSTRVMGS KMMNGIGGSG DFARSSYLSI 400
    FLSPSTAKGG KISAIVPMAA HVDHIMQDAQ IFVTEQGLAD LRGLSPVQRA 450
    REIISKCAHP DYRPMLQDYF DRALKNSFGK HTPHLLTEAL SWHQRFIDTG 500
    TMLPS 505
    Length:505
    Mass (Da):54,826
    Last modified:July 22, 2008 - v1
    Checksum:iC02A8779588D2510
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ631551 Genomic DNA. Translation: ACD85596.1.
    JX475924 Genomic DNA. Translation: AGG68319.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ631551 Genomic DNA. Translation: ACD85596.1 .
    JX475924 Genomic DNA. Translation: AGG68319.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4EU3 X-ray 1.58 A/B 1-505 [» ]
    4EU4 X-ray 2.80 A/B 1-505 [» ]
    4EU5 X-ray 1.74 A/B 1-505 [» ]
    4EU6 X-ray 1.99 A/B 1-505 [» ]
    4EU7 X-ray 1.70 A/B 1-505 [» ]
    4EU8 X-ray 1.81 A/B 1-505 [» ]
    4EU9 X-ray 1.48 A/B 1-505 [» ]
    4EUA X-ray 2.40 A/B 1-505 [» ]
    4EUB X-ray 1.97 A/B 1-505 [» ]
    4EUC X-ray 2.64 A/B 1-505 [» ]
    4EUD X-ray 1.95 A/B 1-505 [» ]
    4FAC X-ray 2.05 A/B 1-505 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-17982.

    Family and domain databases

    InterProi IPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    IPR017821. Succinate_CoA_transferase.
    [Graphical view ]
    Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03458. YgfH_subfam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure of a NADH-insensitive hexameric citrate synthase that resists acid inactivation."
      Francois J.A., Starks C.M., Sivanuntakorn S., Jiang H., Ransome A.E., Nam J.W., Constantine C.Z., Kappock T.J.
      Biochemistry 45:13487-13499(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 10-8Imported and 1023Imported.
    2. "A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti."
      Mullins E.A., Francois J.A., Kappock T.J.
      J. Bacteriol. 190:4933-4940(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 10-8Imported and 1023Imported.
    3. Kappock T.J.
      Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 1023Imported.
    4. "Crystal structures of Acetobacter aceti succinyl-coenzyme A (CoA):acetate CoA-transferase reveal specificity determinants and illustrate the mechanism used by class I CoA-transferases."
      Mullins E.A., Kappock T.J.
      Biochemistry 51:8422-8434(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) IN COMPLEX WITH COENZYMEA.
    5. "Succinyl-CoA:acetate CoA-transferase from Acetobacter aceti."
      Mullins E.A., Kappock T.J.
      Submitted (MAY-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS).
    6. "Functional analysis of the acetic acid resistance (aar) gene cluster in Acetobacter aceti strain 1023."
      Mullins E.A., Kappock T.J.
      Acetic Acid Bacteria 2:e3-e3(2013)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 10-8Imported.

    Entry informationi

    Entry nameiB3EY95_ACEAC
    AccessioniPrimary (citable) accession number: B3EY95
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3