Potassium channel toxin alpha-KTx 16.7 precursor - Mesobuthus gibbosus (Mediterranean checkered scorpion)

Functionⁱ

May play a role in blocking voltage-gated potassium channels Kv1.2/KCNA2, and Kv1.3/KCNA3. Blocks the voltage-gated potassium channel Kv1.3/KCNA3, with an IC₅₀ of 118.3 +-55.8 nM.1 Publication

Miscellaneous

Has no effect on rat Kv1.2/KCNA2 channel.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	50	Basic residue of the functional dyadBy similarity		1
Siteⁱ	59	Aromatic residue of the functional dyadBy similarity		1

GO - Molecular functionⁱ

ion channel inhibitor activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

defense response Source: InterPro
pathogenesis Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Ion channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Molecular function

Ion channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium channel toxin alpha-KTx 16.7 Alternative name(s): Alpha-KTx 16.5 MegKTx31 Publication
Organismⁱ	Mesobuthus gibbosus (Mediterranean checkered scorpion)
Taxonomic identifierⁱ	123226 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Mesobuthus

Subcellular locationⁱ

Secreted
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Novel potassium channel blocker venom peptides from Mesobuthus gibbosus (Scorpiones: Buthidae)."
  Diego-Garcia E., Peigneur S., Debaveye S., Gheldof E., Tytgat J., Caliskan F.
  Toxicon 61:72-82(2013) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-59, FUNCTION, MASS SPECTROMETRY.

GO - Cellular componentⁱ

extracellular region Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	1 PublicationAdd BLAST		22
PeptideⁱPRO_0000421235	23 – 59	Potassium channel toxin alpha-KTx 16.7Add BLAST		37

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	30 ↔ 51	By similarity
Disulfide bondⁱ	36 ↔ 56	By similarity
Disulfide bondⁱ	40 ↔ 58	By similarity

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Expressed by the venom gland.1 Publication

Structureⁱ

3D structure databases

SMRⁱ	B3EWY1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 16 subfamily.Sequence analysis

Keywords - Domainⁱ

Signal

Family and domain databases

Gene3Dⁱ	3.30.30.10. 1 hit.
InterProⁱ	View protein in InterPro IPR003614. Scorpion_toxin-like. IPR001947. Scorpion_toxinS_K_inh.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00451. Toxin_2. 1 hit.
PRINTSⁱ	PR00286. CHARYBDTOXIN.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD003586. Scorpion_toxinS. 1 hit.
SUPFAMⁱ	SSF57095. SSF57095. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01138. SCORP_SHORT_TOXIN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

B3EWY1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKILSILLIA LVICSISICT EAFGLIDVKC SASRECWVAC KKVTGSGQGK 

CQNNQCRCY

Length:59

Mass (Da):6,402

Last modified:April 16, 2014 - v2

Checksum:ⁱ60CD0E046C277553

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	21	E → K in AFX61610 (PubMed:23142506).Curated		1

Mass spectrometryⁱ

Molecular mass is 4066.6 Da from positions 23 - 59. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	JX025013 mRNA. Translation: AFX61609.1. JX025014 mRNA. Translation: AFX61610.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

JX025013 mRNA. Translation: AFX61609.1.
JX025014 mRNA. Translation: AFX61610.1.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	JX025013 mRNA. Translation: AFX61609.1. JX025014 mRNA. Translation: AFX61610.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

JX025013 mRNA. Translation: AFX61609.1.
JX025014 mRNA. Translation: AFX61610.1.

3D structure databases

SMRⁱ	B3EWY1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

Gene3Dⁱ	3.30.30.10. 1 hit.
InterProⁱ	View protein in InterPro IPR003614. Scorpion_toxin-like. IPR001947. Scorpion_toxinS_K_inh.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00451. Toxin_2. 1 hit.
PRINTSⁱ	PR00286. CHARYBDTOXIN.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD003586. Scorpion_toxinS. 1 hit.
SUPFAMⁱ	SSF57095. SSF57095. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01138. SCORP_SHORT_TOXIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KA167_MESGB
Accessionⁱ	B3EWY1Primary (citable) accession number: B3EWY1 Secondary accession number(s): K7WHX1, K7WPN2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 6, 2013
	Last sequence update:	April 16, 2014
	Last modified:	May 10, 2017
	This is version 12 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Animal Toxin Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Direct protein sequencing

Documents

Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries
SIMILARITY comments
Index of protein domains and families

UniProtKB - B3EWY1 (KA167_MESGB)

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Potassium channel toxin alpha-KTx 16.7

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Functionⁱ

Miscellaneous

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Expressionⁱ

Tissue specificityⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Family and domain databases

Sequenceⁱ

Experimental Info

Mass spectrometryⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B3EWY1 (KA167_MESGB)

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Potassium channel toxin alpha-KTx 16.7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Mass spectrometryⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ