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L-amino-acid oxidase

Bothrops matogrossensis (Pitviper) (Bothrops neuwiedi matogrossensis)
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli


Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). Inhibits growth of B.subtilis strain ATCC 6633 (MIC=32 µM), E.faecalis strain ATCC 12953 (MIC=32 µM), S.aureus strain ATCC 29213 (MIC=32 µM), S.pyogenes strain ATCC 19615 (MIC=8 µM), E.coli strain ATCC 8739 (MIC=4 µM), K.pneumoniae strain ATCC 13885 (MIC=2 µM), P.mirabilis strain ATCC 25933 (MIC=2 µM), P.aeruginosa strain ATCC 15442 (MIC=8 µM) and S.typhimurium strain ATCC 14028 (MIC=8 µM).By similarity1 Publication

Catalytic activityi

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.1 Publication


FADBy similarity

GO - Molecular functioni

GO - Biological processi


Molecular functionAntibiotic, Antimicrobial, Hemostasis impairing toxin, Oxidoreductase, Toxin
Biological processApoptosis, Cytolysis, Hemolysis
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
L-amino-acid oxidase1 Publication (EC: Publication)
Short name:
Bm-LAO1 Publication
Short name:
LAAOBy similarity
Short name:
LAOBy similarity
OrganismiBothrops matogrossensis (Pitviper) (Bothrops neuwiedi matogrossensis)
Taxonomic identifieri1171125 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeBothrops

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti


PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000417918‹1 – ›31L-amino-acid oxidaseAdd BLAST›31

Post-translational modificationi

N-glycosylated.By similarity


Tissue specificityi

Expressed by the venom gland.1 Publication


Subunit structurei

Homodimer; non-covalently linked.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family. FIG1 subfamily.Sequence analysis


Sequence statusi: Fragments.

B3EWI9-1 [UniParc]FASTAAdd to basket

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        10         20         30 
Mass (Da):3,751
Last modified:June 13, 2012 - v1

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11 Publication1
Non-adjacent residuesi13 – 141 Publication2
Non-adjacent residuesi21 – 221 Publication2
Non-terminal residuei311 Publication1


3D structure databases


Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases


Entry informationi

Entry nameiOXLA_BOTMT
AccessioniPrimary (citable) accession number: B3EWI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: June 13, 2012
Last modified: January 7, 2015
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program


Keywords - Technical termi

Direct protein sequencing


  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.