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Protein

Laccase

Gene
N/A
Organism
Agaricus placomyces (Mushroom)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.1 Publication

Kineticsi

  1. KM=0.392 mM for hydroquinone1 Publication
  2. KM=0.775 mM for ABTS1 Publication

    pH dependencei

    Optimum pH is 5.2 with ABTS as substrate. Optimum pH is 6.8 with hydroquinone as substrate.1 Publication

    Temperature dependencei

    Optimum temperature is 30 degrees Celsius.1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase1 Publication (EC:1.10.3.21 Publication)
    OrganismiAgaricus placomyces (Mushroom)
    Taxonomic identifieri182818 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›15›15LaccasePRO_0000417451Add
    BLAST

    Sequencei

    Sequence statusi: Fragment.

    Length:15
    Mass (Da):1,569
    Last modified:May 16, 2012 - v1
    Checksum:iCFF7C40A165E6882
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei15 – 1511 Publication

    Cross-referencesi

    3D structure databases

    ModBaseiSearch...
    MobiDBiSearch...

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Family and domain databases

    ProtoNetiSearch...

    Publicationsi

    1. "A laccase with antiproliferative activity against tumor cells from the mycorrhizal fungus Agaricus placomyces."
      Sun J., Wu Y.Y., Xu L.J., Zhu M.J., Zhang G.Q., Wang H.X.
      Submitted (MAR-2012) to UniProtKB
      Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES.
      Tissue: Fruiting body1 Publication.

    Entry informationi

    Entry nameiLAC_AGAPC
    AccessioniPrimary (citable) accession number: B3EWI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2012
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 4 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.