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Reviewed, UniProtKB/Swiss-Prot B3EU56 (LSPA_AMOA5)

Last modified November 3, 2009. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Lipoprotein signal peptidase
    EC=3.4.23.36
Alternative name(s):
    Prolipoprotein signal peptidase
    Signal peptidase II
      Short name=SPase II
Gene names
Name: lspA
Ordered Locus Names: Aasi_0018
OrganismAmoebophilus asiaticus (strain 5a2) [Complete proteome] [HAMAP]
Taxonomic identifier452471 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Candidatus Amoebophilus

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Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity.

Catalytic activity

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP MF_00161

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP MF_00161

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the peptidase A8 family.

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Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionAspartyl protease
Hydrolase
Protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: HAMAP

   Molecular functionaspartic-type endopeptidase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236Lipoprotein signal peptidase HAMAP MF_00161
PRO_1000097228

Regions

Transmembrane8 – 2821 Potential
Transmembrane44 – 6421 Potential
Transmembrane68 – 8821 Potential
Transmembrane98 – 11821 Potential
Transmembrane166 – 18621 Potential

Sites

Active site1151 By similarity
Active site1741 By similarity

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Sequences

Sequence LengthMass (Da)Tools
B3EU56-1 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 1A4F01E3EAB8F1EB

FASTA23627,005
        10         20         30         40         50         60 
MTKKVWKFYG IALLAVVIDQ VLKLWVYFNM QMGTLGQIKL LGNWFKLFYT LNPGMAFGIQ 

        70         80         90        100        110        120 
FGFTYDKVLL TIIRIIATSM IIKYIWNLAK ETNSSKWLLW GWSLILGGAA GNGIDSIFYG 

       130        140        150        160        170        180 
KILHNAPYGA PMSWFYGQVI DMLYIDLWSG RLPDWVPWYS GYYVTCLPVF NLADVAILAG 

       190        200        210        220        230 
VALIVLDKRA SIQQPVQKYE ATEVTDSELL ETRHELVDPI TEHNNTEHNH PEVEDK

« Hide

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References

[1]"Complete sequence of Candidatus Amoebophilus asiaticus 5a2."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Horn M., Richardson P.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP001102 Genomic DNA. Translation: ACE05475.1.
RefSeqYP_001957204.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

MEROPSA08.001.

Genome annotation databases

GeneID6377699.
GenomeReviewsGene locus Aasi_0018 in contig CP001102_GR.
KEGGaas:Aasi_0018.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMANEGMAWG.

Family and domain databases

HAMAPMF_00161.
[Tree]
InterProIPR001872. Peptidase_A8.
[Graphical view]
PRINTSPR00781. LIPOSIGPTASE.
PROSITEPS00855. SPASE_II. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLSPA_AMOA5
AccessionPrimary (citable) accession number: B3EU56
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: November 3, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents