Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B3EU51

- PNP_AMOA5

UniProt

B3EU51 - PNP_AMOA5

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Amoebophilus asiaticus (strain 5a2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi494 – 4941MagnesiumUniRule annotation
    Metal bindingi500 – 5001MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciAASI452471:GKEN-15-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Aasi_0013
    OrganismiAmoebophilus asiaticus (strain 5a2)
    Taxonomic identifieri452471 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesAmoebophilaceaeCandidatus Amoebophilus
    ProteomesiUP000001227: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 713713Polyribonucleotide nucleotidyltransferasePRO_1000147879Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi452471.Aasi_0013.

    Structurei

    3D structure databases

    ProteinModelPortaliB3EU51.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini561 – 62363KHUniRule annotationAdd
    BLAST
    Domaini633 – 70270S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiGTENTIC.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3EU51-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNKIISKTI SLPEHREITI ETGKLAKQAD GSVVVRMGDT MLLATVVFKQ    50
    ELDPTVDFLP LHVEYQEKFA AAGKIPGGFL RREGKLGDHE VLISRLVDRA 100
    IRPLFPDNYK HETQINIFLI SADPEILPES LAGLAASAAL MISPIPFEGP 150
    ISEVRVARID GQFVVNPTQS ALEKADIDLM VGGSEKNILM VEGEMDEVQE 200
    ADIIAAIQFA HEAIKLQCQV QKELADAVAT LKFEAEPLQE TENFELKDRT 250
    FKALYDKVYA TAKKGITNKH LRKSSFKQIK KEYLKELLQQ DPETSTVHFD 300
    KYYYELEKQV VRDLALNEGL RLDGRKLDEI RAIESEIDYL PAAHGSSLFT 350
    RGETQSLTTV TLGTKLDEQL IDRALLNGYS RFMLHYNFPS FSTGEVKFNR 400
    GPGRREIGHG HLAMRALKKV LPLDTENPYT IRIVSDILES NGSSSMATVC 450
    AGSLALMDAG ISIRSAVSGI AMGLLMDEQT GKHAILSDIL GDEDALGDMD 500
    FKVAGTAKGI TACQMDIKVS GLTPQLLQKA LEQAKAGRLH ILGEMNKTIT 550
    EPKTTYKKHA PSFSTMTIPK NMIGAVIGPS GKIVQEMQRE TGTTIIIEEV 600
    EGKGIIKFFG PNQEAVQSAE KRVKDIVAEP VVGDVYQGTV KSIVPFGAFV 650
    EFMPGKEGLL HISEVKWERI ENLDQVLELG EVIPVKLLEI DPKSGKYKLS 700
    RKVLLPNPKA TEA 713
    Length:713
    Mass (Da):78,662
    Last modified:July 22, 2008 - v1
    Checksum:iC49CBD870E1563E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001102 Genomic DNA. Translation: ACE05470.1.
    RefSeqiYP_001957199.1. NC_010830.1.

    Genome annotation databases

    EnsemblBacteriaiACE05470; ACE05470; Aasi_0013.
    GeneIDi6377694.
    KEGGiaas:Aasi_0013.
    PATRICi21265313. VBICanAmo76781_0016.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001102 Genomic DNA. Translation: ACE05470.1 .
    RefSeqi YP_001957199.1. NC_010830.1.

    3D structure databases

    ProteinModelPortali B3EU51.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 452471.Aasi_0013.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE05470 ; ACE05470 ; Aasi_0013 .
    GeneIDi 6377694.
    KEGGi aas:Aasi_0013.
    PATRICi 21265313. VBICanAmo76781_0016.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi GTENTIC.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci AASI452471:GKEN-15-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the amoeba symbiont 'Candidatus Amoebophilus asiaticus' reveals common mechanisms for host cell interaction among amoeba-associated bacteria."
      Schmitz-Esser S., Tischler P., Arnold R., Montanaro J., Wagner M., Rattei T., Horn M.
      J. Bacteriol. 192:1045-1057(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 5a2.

    Entry informationi

    Entry nameiPNP_AMOA5
    AccessioniPrimary (citable) accession number: B3EU51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3