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B3EU51

- PNP_AMOA5

UniProt

B3EU51 - PNP_AMOA5

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Amoebophilus asiaticus (strain 5a2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi494 – 4941MagnesiumUniRule annotation
Metal bindingi500 – 5001MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciAASI452471:GKEN-15-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Aasi_0013
OrganismiAmoebophilus asiaticus (strain 5a2)
Taxonomic identifieri452471 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesAmoebophilaceaeCandidatus Amoebophilus
ProteomesiUP000001227: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 713713Polyribonucleotide nucleotidyltransferasePRO_1000147879Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi452471.Aasi_0013.

Structurei

3D structure databases

ProteinModelPortaliB3EU51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini561 – 62363KHUniRule annotationAdd
BLAST
Domaini633 – 70270S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3EU51-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNKIISKTI SLPEHREITI ETGKLAKQAD GSVVVRMGDT MLLATVVFKQ
60 70 80 90 100
ELDPTVDFLP LHVEYQEKFA AAGKIPGGFL RREGKLGDHE VLISRLVDRA
110 120 130 140 150
IRPLFPDNYK HETQINIFLI SADPEILPES LAGLAASAAL MISPIPFEGP
160 170 180 190 200
ISEVRVARID GQFVVNPTQS ALEKADIDLM VGGSEKNILM VEGEMDEVQE
210 220 230 240 250
ADIIAAIQFA HEAIKLQCQV QKELADAVAT LKFEAEPLQE TENFELKDRT
260 270 280 290 300
FKALYDKVYA TAKKGITNKH LRKSSFKQIK KEYLKELLQQ DPETSTVHFD
310 320 330 340 350
KYYYELEKQV VRDLALNEGL RLDGRKLDEI RAIESEIDYL PAAHGSSLFT
360 370 380 390 400
RGETQSLTTV TLGTKLDEQL IDRALLNGYS RFMLHYNFPS FSTGEVKFNR
410 420 430 440 450
GPGRREIGHG HLAMRALKKV LPLDTENPYT IRIVSDILES NGSSSMATVC
460 470 480 490 500
AGSLALMDAG ISIRSAVSGI AMGLLMDEQT GKHAILSDIL GDEDALGDMD
510 520 530 540 550
FKVAGTAKGI TACQMDIKVS GLTPQLLQKA LEQAKAGRLH ILGEMNKTIT
560 570 580 590 600
EPKTTYKKHA PSFSTMTIPK NMIGAVIGPS GKIVQEMQRE TGTTIIIEEV
610 620 630 640 650
EGKGIIKFFG PNQEAVQSAE KRVKDIVAEP VVGDVYQGTV KSIVPFGAFV
660 670 680 690 700
EFMPGKEGLL HISEVKWERI ENLDQVLELG EVIPVKLLEI DPKSGKYKLS
710
RKVLLPNPKA TEA
Length:713
Mass (Da):78,662
Last modified:July 22, 2008 - v1
Checksum:iC49CBD870E1563E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001102 Genomic DNA. Translation: ACE05470.1.
RefSeqiWP_012472242.1. NC_010830.1.
YP_001957199.1. NC_010830.1.

Genome annotation databases

EnsemblBacteriaiACE05470; ACE05470; Aasi_0013.
GeneIDi6377694.
KEGGiaas:Aasi_0013.
PATRICi21265313. VBICanAmo76781_0016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001102 Genomic DNA. Translation: ACE05470.1 .
RefSeqi WP_012472242.1. NC_010830.1.
YP_001957199.1. NC_010830.1.

3D structure databases

ProteinModelPortali B3EU51.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452471.Aasi_0013.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE05470 ; ACE05470 ; Aasi_0013 .
GeneIDi 6377694.
KEGGi aas:Aasi_0013.
PATRICi 21265313. VBICanAmo76781_0016.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci AASI452471:GKEN-15-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the amoeba symbiont 'Candidatus Amoebophilus asiaticus' reveals common mechanisms for host cell interaction among amoeba-associated bacteria."
    Schmitz-Esser S., Tischler P., Arnold R., Montanaro J., Wagner M., Rattei T., Horn M.
    J. Bacteriol. 192:1045-1057(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5a2.

Entry informationi

Entry nameiPNP_AMOA5
AccessioniPrimary (citable) accession number: B3EU51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3