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B3EU03 (B3EU03_AMOA5) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase HAMAP MF_00008
Short name=TS HAMAP MF_00008
Short name=TSase HAMAP MF_00008
EC=2.1.1.45 HAMAP MF_00008
Gene names
Name:thyA HAMAP MF_00008
Ordered Locus Names:Aasi_1410
OrganismAmoebophilus asiaticus (strain 5a2) [Complete proteome] [HAMAP]
Taxonomic identifier452471 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Candidatus Amoebophilus

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Subunit structure

Homodimer By similarity. HAMAP MF_00008 SAAS SAAS023451

Subcellular location

Cytoplasm By similarity HAMAP MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. RuleBase RU004150

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily. HAMAP MF_00008

Ontologies

Keywords
   Biological processNucleotide biosynthesis HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451
   Cellular componentCytoplasm HAMAP MF_00008
   Molecular functionMethyltransferase SAAS SAAS023451 HAMAP MF_00008 RuleBase RU000500
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthymidylate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1461 By similarity HAMAP MF_00008

Sequences

Sequence LengthMass (Da)Tools
B3EU03 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: B1FBDD548D5CEA35

FASTA26430,088
        10         20         30         40         50         60 
MKQYLSLLGH VLHNGQEKKD RTGTGTKSIF GYQMRFNLAE GFPLMTTKKL HMKSIIYELL 

        70         80         90        100        110        120 
WFLQGNTNIG YLNQNGVTIW DEWADAQGNL GPIYGYQWRS WPTSNHGKVD QIEQVIKQIK 

       130        140        150        160        170        180 
ANPDSRRLLV SAWNVGELDK MALPPCHVLF QFYVANNKLS CQLYQRSADI FLGIPFNIAS 

       190        200        210        220        230        240 
YALLTTMVAQ VCDLEVGEFI HTLGDAHLYN NHIEQAQLQL SRAPRPLPTL KVNSAVKDIF 

       250        260 
AFQYDDFCIE NYNPYPSIKA PIAV

« Hide

References

[1]"Complete sequence of Candidatus Amoebophilus asiaticus 5a2."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Horn M., Richardson P.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 5a2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001102 Genomic DNA. Translation: ACE06705.1.
RefSeqYP_001958434.1. NC_010830.1.

3D structure databases

ProteinModelPortalB3EU03.
SMRB3EU03. Positions 1-264.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3EU03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6377539.
GenomeReviewsGene locus Aasi_1410 in contig CP001102_GR.
KEGGaas:Aasi_1410.
PATRIC21268637. VBICanAmo76781_1637.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG588098.
OMADIPRMKL.

Family and domain databases

HAMAPMF_00008. Thymidy_synth_bact.
[Tree]
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
Gene3DG3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
KOK00560.
PANTHERPTHR11549:SF2. Thymidylat_synth_C. 1 hit.
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. Thym_sym. 2 hits.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3EU03_AMOA5
AccessionPrimary (citable) accession number: B3EU03
Entry history
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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