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B3ETW5

- SYL_AMOA5

UniProt

B3ETW5 - SYL_AMOA5

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Amoebophilus asiaticus (strain 5a2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei701 – 7011ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAASI452471:GKEN-1493-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Aasi_1363
    OrganismiAmoebophilus asiaticus (strain 5a2)
    Taxonomic identifieri452471 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesAmoebophilaceaeCandidatus Amoebophilus
    ProteomesiUP000001227: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 923923Leucine--tRNA ligasePRO_1000091287Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi452471.Aasi_1363.

    Structurei

    3D structure databases

    ProteinModelPortaliB3ETW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5212"HIGH" regionAdd
    BLAST
    Motifi698 – 7025"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiMAFAGPP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3ETW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHYDFKAIE QKWQQYWKNN QIFRTTIEPS KPKYYILDMF PYPSGEGLHV    50
    GHPLGYIASD IVARYKRSKG YQVLHPMGFD AFGLPAEQFA IQTGQHPAIT 100
    TAKNIGRYKQ QLCQLGLSYD WDRCISTCEP AYYKWTQWIF IQLFNSWYDI 150
    SLQKARPIDE LITLFDQQGN QQVQASCDKE VSLFTAKEWQ AMDEESKQQH 200
    LLAYRLAFLE DTTVNWCPEL GTVLANEEVK DGLSERGGYP VIRKQMKQWS 250
    LRITAYTDRL LAGLEHLKWP LSTKEMQRNW IGRSIGAELN FTVIANGQEH 300
    TIPVFTTRPD TLFGVTYLAL SPEHPLAKLI STGTQQAAID TYITQATNRS 350
    ERDRLADVNH VTGMFTGAYA IHPFTKQPLP IWIADYVLAG YGTGAVMGVP 400
    AHDSRDYAFA QHFQLPIIQV VAGGDTAQSA YEAREGSLFN SQFLNGLSIQ 450
    EATKQAIQKL ESLGIGKQKT TYRLRNAIFS RQRYWGEPIP IYYKNNIPYP 500
    IPAEELPLEL PSLASFKPTP TGEPPLGHAP NWKTKEGYPI ELSTMPGWAG 550
    SSWYFFRYMD PNNEASFVGS TAQNYWQAVD LYLGGAEHAT GHLLYARFWT 600
    QFLYDLGYVN IEEPFQELIH QGMIQGKSSF VYRIKGTNQF VSYNLRHAYE 650
    TTAMHVDIHL VKNNILDLER FKNWRPDLQT ATFVLENGQY ICGSEVEKMS 700
    KSKYNTVNPD TVVEQYGADT LRLYTMFLGP IEQAKPWDMH GIEGVFRFLV 750
    KVWRLFYLEK GAIITNEVPT KEVQKAIHKA IKKVEEDIKR YAFNTAVSNL 800
    MICVNELTAL KCNNRAALTN LVLILAPFAP HLAEELWEIL GHQHSIAQAP 850
    FPTYEEIYLQ EETYEYPIAI NGKVRAKINF PVDMPQGQIE EQVLTHESIQ 900
    KWIQGQQIKR VIVISSKMVN IVI 923
    Length:923
    Mass (Da):105,607
    Last modified:July 22, 2008 - v1
    Checksum:iAAB6AE51D668398C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001102 Genomic DNA. Translation: ACE06667.1.
    RefSeqiWP_012473409.1. NC_010830.1.
    YP_001958396.1. NC_010830.1.

    Genome annotation databases

    EnsemblBacteriaiACE06667; ACE06667; Aasi_1363.
    GeneIDi6377662.
    KEGGiaas:Aasi_1363.
    PATRICi21268499. VBICanAmo76781_1573.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001102 Genomic DNA. Translation: ACE06667.1 .
    RefSeqi WP_012473409.1. NC_010830.1.
    YP_001958396.1. NC_010830.1.

    3D structure databases

    ProteinModelPortali B3ETW5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 452471.Aasi_1363.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE06667 ; ACE06667 ; Aasi_1363 .
    GeneIDi 6377662.
    KEGGi aas:Aasi_1363.
    PATRICi 21268499. VBICanAmo76781_1573.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi MAFAGPP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci AASI452471:GKEN-1493-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the amoeba symbiont 'Candidatus Amoebophilus asiaticus' reveals common mechanisms for host cell interaction among amoeba-associated bacteria."
      Schmitz-Esser S., Tischler P., Arnold R., Montanaro J., Wagner M., Rattei T., Horn M.
      J. Bacteriol. 192:1045-1057(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 5a2.

    Entry informationi

    Entry nameiSYL_AMOA5
    AccessioniPrimary (citable) accession number: B3ETW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3