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B3ETW5

- SYL_AMOA5

UniProt

B3ETW5 - SYL_AMOA5

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Amoebophilus asiaticus (strain 5a2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei701 – 7011ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAASI452471:GKEN-1493-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Aasi_1363
OrganismiAmoebophilus asiaticus (strain 5a2)
Taxonomic identifieri452471 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesAmoebophilaceaeCandidatus Amoebophilus
ProteomesiUP000001227: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 923923Leucine--tRNA ligasePRO_1000091287Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi452471.Aasi_1363.

Structurei

3D structure databases

ProteinModelPortaliB3ETW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionAdd
BLAST
Motifi698 – 7025"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3ETW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHYDFKAIE QKWQQYWKNN QIFRTTIEPS KPKYYILDMF PYPSGEGLHV
60 70 80 90 100
GHPLGYIASD IVARYKRSKG YQVLHPMGFD AFGLPAEQFA IQTGQHPAIT
110 120 130 140 150
TAKNIGRYKQ QLCQLGLSYD WDRCISTCEP AYYKWTQWIF IQLFNSWYDI
160 170 180 190 200
SLQKARPIDE LITLFDQQGN QQVQASCDKE VSLFTAKEWQ AMDEESKQQH
210 220 230 240 250
LLAYRLAFLE DTTVNWCPEL GTVLANEEVK DGLSERGGYP VIRKQMKQWS
260 270 280 290 300
LRITAYTDRL LAGLEHLKWP LSTKEMQRNW IGRSIGAELN FTVIANGQEH
310 320 330 340 350
TIPVFTTRPD TLFGVTYLAL SPEHPLAKLI STGTQQAAID TYITQATNRS
360 370 380 390 400
ERDRLADVNH VTGMFTGAYA IHPFTKQPLP IWIADYVLAG YGTGAVMGVP
410 420 430 440 450
AHDSRDYAFA QHFQLPIIQV VAGGDTAQSA YEAREGSLFN SQFLNGLSIQ
460 470 480 490 500
EATKQAIQKL ESLGIGKQKT TYRLRNAIFS RQRYWGEPIP IYYKNNIPYP
510 520 530 540 550
IPAEELPLEL PSLASFKPTP TGEPPLGHAP NWKTKEGYPI ELSTMPGWAG
560 570 580 590 600
SSWYFFRYMD PNNEASFVGS TAQNYWQAVD LYLGGAEHAT GHLLYARFWT
610 620 630 640 650
QFLYDLGYVN IEEPFQELIH QGMIQGKSSF VYRIKGTNQF VSYNLRHAYE
660 670 680 690 700
TTAMHVDIHL VKNNILDLER FKNWRPDLQT ATFVLENGQY ICGSEVEKMS
710 720 730 740 750
KSKYNTVNPD TVVEQYGADT LRLYTMFLGP IEQAKPWDMH GIEGVFRFLV
760 770 780 790 800
KVWRLFYLEK GAIITNEVPT KEVQKAIHKA IKKVEEDIKR YAFNTAVSNL
810 820 830 840 850
MICVNELTAL KCNNRAALTN LVLILAPFAP HLAEELWEIL GHQHSIAQAP
860 870 880 890 900
FPTYEEIYLQ EETYEYPIAI NGKVRAKINF PVDMPQGQIE EQVLTHESIQ
910 920
KWIQGQQIKR VIVISSKMVN IVI
Length:923
Mass (Da):105,607
Last modified:July 22, 2008 - v1
Checksum:iAAB6AE51D668398C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001102 Genomic DNA. Translation: ACE06667.1.
RefSeqiWP_012473409.1. NC_010830.1.
YP_001958396.1. NC_010830.1.

Genome annotation databases

EnsemblBacteriaiACE06667; ACE06667; Aasi_1363.
GeneIDi6377662.
KEGGiaas:Aasi_1363.
PATRICi21268499. VBICanAmo76781_1573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001102 Genomic DNA. Translation: ACE06667.1 .
RefSeqi WP_012473409.1. NC_010830.1.
YP_001958396.1. NC_010830.1.

3D structure databases

ProteinModelPortali B3ETW5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452471.Aasi_1363.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE06667 ; ACE06667 ; Aasi_1363 .
GeneIDi 6377662.
KEGGi aas:Aasi_1363.
PATRICi 21268499. VBICanAmo76781_1573.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci AASI452471:GKEN-1493-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the amoeba symbiont 'Candidatus Amoebophilus asiaticus' reveals common mechanisms for host cell interaction among amoeba-associated bacteria."
    Schmitz-Esser S., Tischler P., Arnold R., Montanaro J., Wagner M., Rattei T., Horn M.
    J. Bacteriol. 192:1045-1057(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5a2.

Entry informationi

Entry nameiSYL_AMOA5
AccessioniPrimary (citable) accession number: B3ETW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3