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B3ESI8 (B3ESI8_AMOA5) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639 RuleBase RU003664
EC=6.3.2.9 HAMAP MF_00639 RuleBase RU003664
Alternative name(s):
D-glutamic acid-adding enzyme HAMAP MF_00639
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase HAMAP MF_00639
Gene names
Name:murD HAMAP MF_00639
Ordered Locus Names:Aasi_0816
OrganismAmoebophilus asiaticus (strain 5a2) [Complete proteome] [HAMAP]
Taxonomic identifier452471 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Candidatus Amoebophilus

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Subcellular location

Cytoplasm By similarity HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762.

Sequence similarities

Belongs to the MurCDEF family. HAMAP MF_00639 RuleBase RU003630

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding109 – 1157ATP By similarity HAMAP MF_00639

Sequences

Sequence LengthMass (Da)Tools
B3ESI8 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 69B2CA73DDC32CDF

FASTA45050,231
        10         20         30         40         50         60 
MKKLVVLGAG ESGTGAALLA QAKGYQVFVS DKNIITKGYK QQLLDHKIEF EECKHTWDKI 

        70         80         90        100        110        120 
KIADEVIKSP GIPNHIAIIQ ALQEASIPII DEVEFASRYT KASLIAITGS NGKSTTTHLA 

       130        140        150        160        170        180 
YHLLKAGGLN VGIAGNIGTS FARKVLLEEH NYYVLELSSF QLEHLQTFKA DIACILNITP 

       190        200        210        220        230        240 
DHLDRYDNQL NNYIAAKFRI LRNMIKEGYF IYNQDDTNIR EYLVKQTTNL PQLYPISLTQ 

       250        260        270        280        290        300 
STHHGAYVEN NHLHFVGDNY NFQLPTQTLP LLGKHNIYNT MAAISIASLL GLSYASILDG 

       310        320        330        340        350        360 
LRTFKGLPHR MEWIANVNQV SFYNDSKATN VESAAVALES FTSPIIWIAG GYDKGNDYNV 

       370        380        390        400        410        420 
LKPIVKNSVK ALICLGKDNQ TICKAFKESN IPIYETQVMQ EAVSLAYTLA KPQDIVLLSP 

       430        440        450 
ACASFDLFKN FEDRGEQFRY AVQQLLTSIN

« Hide

References

[1]"Complete sequence of Candidatus Amoebophilus asiaticus 5a2."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Horn M., Richardson P.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 5a2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001102 Genomic DNA. Translation: ACE06190.1.
RefSeqYP_001957919.1. NC_010830.1.

3D structure databases

ProteinModelPortalB3ESI8.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3ESI8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6376949.
GenomeReviewsGene locus Aasi_0816 in contig CP001102_GR.
KEGGaas:Aasi_0816.
PATRIC21267184. VBICanAmo76781_0925.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG750024.
OMAACASWDM.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB3ESI8_AMOA5
AccessionPrimary (citable) accession number: B3ESI8
Entry history
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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