B3ESC6 (PTH_AMOA5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	Aasi_0745

Organism

Amoebophilus asiaticus (strain 5a2) [Complete proteome] [HAMAP]

Taxonomic identifier

452471 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Candidatus Amoebophilus

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity. HAMAP MF_00083
Subcellular location	Cytoplasm By similarity HAMAP MF_00083.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_1000092906

Sequences

	Sequence		Length	Mass (Da)
	B3ESC6 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 6051D32F244AE21F	FASTA	191	21,618
	10 20 30 40 50 60 MKYLIIGLGN IGHEYELTRH NIGFQVLDQL AAEHQVKFQI DRLALITSFS YKGRSLYLIK 70 80 90 100 110 120 PTTYMNLSGK AAQYWINKLK IPIENTLTIV DDLALPFGKL RLRPQGSSAG HNGLKSLEEY 130 140 150 160 170 180 LKTQAYPRLR FGIGNDFTKG QQSNYVLSRF KDQELSLLES PINQACKIIK SFSTLGITRT 190 MEQCNADVSI T

References

[1]

"Complete sequence of Candidatus Amoebophilus asiaticus 5a2." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Horn M., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 5a2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001102 Genomic DNA. Translation: ACE06128.1.
RefSeq	YP_001957857.1. NC_010830.1.
3D structure databases
ProteinModelPortal	B3ESC6.
ModBase	Search...
Protein-protein interaction databases
STRING	B3ESC6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6377078.
GenomeReviews	Gene locus Aasi_0745 in contig CP001102_GR.
KEGG	aas:Aasi_0745.
PATRIC	21267020. VBICanAmo76781_0848.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG610927.
OMA	NTFMNNS.
ProtClustDB	PRK05426.
Family and domain databases
HAMAP	MF_00083. Pept_tRNA_hydro_bact. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KO	K01056.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. Pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_AMOA5

Accession

Primary (citable) accession number: B3ESC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program