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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Amoebophilus asiaticus (strain 5a2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAASI452471:GKEN-656-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:Aasi_0599
OrganismiAmoebophilus asiaticus (strain 5a2)
Taxonomic identifieri452471 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesAmoebophilaceaeCandidatus Amoebophilus
ProteomesiUP000001227 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Arginine--tRNA ligasePRO_1000095332Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi452471.Aasi_0599.

Structurei

3D structure databases

ProteinModelPortaliB3ERZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi123 – 13311"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247211.
KOiK01887.
OMAiVGFGTMM.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3ERZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDLVLREA IQNAFQSVFE LSIPLADVNL QPTRKEFEGT HTLIVFPFTT
60 70 80 90 100
TCKVSPEVIA NKIGDWMQTN TQAIASYNVV KGFLNLSIKD TIWLASFNQM
110 120 130 140 150
YQNKHFGYLP SNRQKIVVEY SSPNTNKPLH LGHLRNNFLG HAVSEILQAA
160 170 180 190 200
GYEVYKVNLV NDRGIHICKS MVAYQHWGRG ETPESRGLKG DQLVGKYYVK
210 220 230 240 250
FDQVYKEQVA ALTQTLGDAE QAAKQAPLLQ EAQVMLKQWE AGNEEVLALW
260 270 280 290 300
RKMNGWVYDG FDITYQKLGI TFDKVYYESQ TYLLGKEVVA EGLAKGTFYK
310 320 330 340 350
KQDGSVWIDL TQEGLDEKLL LRADGTSVYI TQDLGTADLR YQDFKPNKLV
360 370 380 390 400
YVVGNEQDYH FEVLAKIMAR LGRPYATDLY HLSYGMVDLP TGKMKSREGT
410 420 430 440 450
VVDADMLIDE MIETAEEHTR ELGKIDGFSK EEAKDLYHIL AMGALKYFLL
460 470 480 490 500
RVDAKKRLLF DPQASIDFQG DTGPFIQYTH ARIAAVLRKV QQADIAFNDI
510 520 530 540 550
VEQENFVLHP LEREVIVELA AFPKKLQESA LAYAPAILAQ HVLEIAKAYN
560 570 580 590
RMYAELSILH EQDTKVQLFR IQLSVLVAQV IKTVMHLLGI VVPERM
Length:596
Mass (Da):67,709
Last modified:July 21, 2008 - v1
Checksum:iB43FCCE03112DB49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001102 Genomic DNA. Translation: ACE06000.1.
RefSeqiWP_012472766.1. NC_010830.1.
YP_001957729.1. NC_010830.1.

Genome annotation databases

EnsemblBacteriaiACE06000; ACE06000; Aasi_0599.
GeneIDi6376447.
KEGGiaas:Aasi_0599.
PATRICi21266675. VBICanAmo76781_0684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001102 Genomic DNA. Translation: ACE06000.1.
RefSeqiWP_012472766.1. NC_010830.1.
YP_001957729.1. NC_010830.1.

3D structure databases

ProteinModelPortaliB3ERZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi452471.Aasi_0599.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACE06000; ACE06000; Aasi_0599.
GeneIDi6376447.
KEGGiaas:Aasi_0599.
PATRICi21266675. VBICanAmo76781_0684.

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247211.
KOiK01887.
OMAiVGFGTMM.
OrthoDBiEOG6JB13C.

Enzyme and pathway databases

BioCyciAASI452471:GKEN-656-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the amoeba symbiont 'Candidatus Amoebophilus asiaticus' reveals common mechanisms for host cell interaction among amoeba-associated bacteria."
    Schmitz-Esser S., Tischler P., Arnold R., Montanaro J., Wagner M., Rattei T., Horn M.
    J. Bacteriol. 192:1045-1057(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5a2.

Entry informationi

Entry nameiSYR_AMOA5
AccessioniPrimary (citable) accession number: B3ERZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2009
Last sequence update: July 21, 2008
Last modified: March 3, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.