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B3EPT7

- NADK_CHLPB

UniProt

B3EPT7 - NADK_CHLPB

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Protein

NAD kinase

Gene

nadK

Organism
Chlorobium phaeobacteroides (strain BS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Proton acceptorUniRule annotation
Binding sitei148 – 1481NADUniRule annotation
Binding sitei165 – 1651NADUniRule annotation
Binding sitei167 – 1671NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 672NADUniRule annotation
Nucleotide bindingi137 – 1382NADUniRule annotation
Nucleotide bindingi178 – 1836NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHA331678:GHME-2485-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Cphamn1_2432
OrganismiChlorobium phaeobacteroides (strain BS1)
Taxonomic identifieri331678 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000001228: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285NAD kinasePRO_1000120841Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331678.Cphamn1_2432.

Structurei

3D structure databases

ProteinModelPortaliB3EPT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiSAYRADG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

B3EPT7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFGIVVNIN RKDALELASE LVIWLKNRSL DYLFDSLSAK ALNVNESSPI
60 70 80 90 100
EAMNTHCDVF ISLGGDGTLL FTSHYSVTKP VIGINVGHLG FLTEFSKEEM
110 120 130 140 150
YGAIEKVLNG SYTIYERTQL EAHIDVEHEK KRFTALNDVV IEKGTYSRIP
160 170 180 190 200
TFNIKLDDEQ LSAYRADGII IATSTGSTAY SLSAGGPVIF PKSNVFVITP
210 220 230 240 250
ICPHMLTVRP IVISDDKHIE VFVDAPDGEF PLNCDGHQRK LLLPGEVISV
260 270 280
KKSEEMINLV ANENRNYCEI LRSKLLWGRE HKPGL
Length:285
Mass (Da):31,769
Last modified:July 22, 2008 - v1
Checksum:i11EE91CBA3CEF5E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001101 Genomic DNA. Translation: ACE05327.1.
RefSeqiWP_012475786.1. NC_010831.1.
YP_001960808.1. NC_010831.1.

Genome annotation databases

EnsemblBacteriaiACE05327; ACE05327; Cphamn1_2432.
GeneIDi6376127.
KEGGicpb:Cphamn1_2432.
PATRICi21387327. VBIChlPha121022_2644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001101 Genomic DNA. Translation: ACE05327.1 .
RefSeqi WP_012475786.1. NC_010831.1.
YP_001960808.1. NC_010831.1.

3D structure databases

ProteinModelPortali B3EPT7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331678.Cphamn1_2432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE05327 ; ACE05327 ; Cphamn1_2432 .
GeneIDi 6376127.
KEGGi cpb:Cphamn1_2432.
PATRICi 21387327. VBIChlPha121022_2644.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi SAYRADG.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci CPHA331678:GHME-2485-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BS1.

Entry informationi

Entry nameiNADK_CHLPB
AccessioniPrimary (citable) accession number: B3EPT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3