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B3EPT7

- NADK_CHLPB

UniProt

B3EPT7 - NADK_CHLPB

Protein

NAD kinase

Gene

nadK

Organism
Chlorobium phaeobacteroides (strain BS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei66 – 661Proton acceptorUniRule annotation
    Binding sitei148 – 1481NADUniRule annotation
    Binding sitei165 – 1651NADUniRule annotation
    Binding sitei167 – 1671NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 672NADUniRule annotation
    Nucleotide bindingi137 – 1382NADUniRule annotation
    Nucleotide bindingi178 – 1836NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPHA331678:GHME-2485-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Cphamn1_2432
    OrganismiChlorobium phaeobacteroides (strain BS1)
    Taxonomic identifieri331678 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
    ProteomesiUP000001228: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285NAD kinasePRO_1000120841Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi331678.Cphamn1_2432.

    Structurei

    3D structure databases

    ProteinModelPortaliB3EPT7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiSAYRADG.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3EPT7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFGIVVNIN RKDALELASE LVIWLKNRSL DYLFDSLSAK ALNVNESSPI    50
    EAMNTHCDVF ISLGGDGTLL FTSHYSVTKP VIGINVGHLG FLTEFSKEEM 100
    YGAIEKVLNG SYTIYERTQL EAHIDVEHEK KRFTALNDVV IEKGTYSRIP 150
    TFNIKLDDEQ LSAYRADGII IATSTGSTAY SLSAGGPVIF PKSNVFVITP 200
    ICPHMLTVRP IVISDDKHIE VFVDAPDGEF PLNCDGHQRK LLLPGEVISV 250
    KKSEEMINLV ANENRNYCEI LRSKLLWGRE HKPGL 285
    Length:285
    Mass (Da):31,769
    Last modified:July 22, 2008 - v1
    Checksum:i11EE91CBA3CEF5E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001101 Genomic DNA. Translation: ACE05327.1.
    RefSeqiWP_012475786.1. NC_010831.1.
    YP_001960808.1. NC_010831.1.

    Genome annotation databases

    EnsemblBacteriaiACE05327; ACE05327; Cphamn1_2432.
    GeneIDi6376127.
    KEGGicpb:Cphamn1_2432.
    PATRICi21387327. VBIChlPha121022_2644.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001101 Genomic DNA. Translation: ACE05327.1 .
    RefSeqi WP_012475786.1. NC_010831.1.
    YP_001960808.1. NC_010831.1.

    3D structure databases

    ProteinModelPortali B3EPT7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 331678.Cphamn1_2432.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE05327 ; ACE05327 ; Cphamn1_2432 .
    GeneIDi 6376127.
    KEGGi cpb:Cphamn1_2432.
    PATRICi 21387327. VBIChlPha121022_2644.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi SAYRADG.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci CPHA331678:GHME-2485-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BS1.

    Entry informationi

    Entry nameiNADK_CHLPB
    AccessioniPrimary (citable) accession number: B3EPT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3