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B3EPG5

- DEF_CHLPB

UniProt

B3EPG5 - DEF_CHLPB

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Protein

Peptide deformylase

Gene
def, Cphamn1_0898
Organism
Chlorobium phaeobacteroides (strain BS1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi94 – 941Iron By similarity
Metal bindingi136 – 1361Iron By similarity
Active sitei137 – 1371 By similarity
Metal bindingi140 – 1401Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCPHA331678:GHME-923-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:Cphamn1_0898
OrganismiChlorobium phaeobacteroides (strain BS1)
Taxonomic identifieri331678 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000001228: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Peptide deformylaseUniRule annotationPRO_1000097299Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331678.Cphamn1_0898.

Structurei

3D structure databases

ProteinModelPortaliB3EPG5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243509.
KOiK01462.
OMAiMEMVFYP.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

B3EPG5-1 [UniParc]FASTAAdd to Basket

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MILPINTYSD EVLRRKAKPL KESDAQLEEL ISNMLESMRN AEGIGLAAPQ    50
VGVSLRLIVV DLSLAEGYEA ASPMVVINPH ILSVKSFNSM EEGCLSIPDV 100
RGDVVRPSAI QLKYRDRNFE ECIGEFDRLA ARVIQHEIDH LDGTLFVDRM 150
QRRDRRKIQK ELDALSRGEI NTNYPVAFHE DSVVK 185
Length:185
Mass (Da):20,903
Last modified:July 22, 2008 - v1
Checksum:iCA3F50FBE356F414
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001101 Genomic DNA. Translation: ACE03843.1.
RefSeqiYP_001959324.1. NC_010831.1.

Genome annotation databases

EnsemblBacteriaiACE03843; ACE03843; Cphamn1_0898.
GeneIDi6374565.
KEGGicpb:Cphamn1_0898.
PATRICi21383934. VBIChlPha121022_0974.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001101 Genomic DNA. Translation: ACE03843.1 .
RefSeqi YP_001959324.1. NC_010831.1.

3D structure databases

ProteinModelPortali B3EPG5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331678.Cphamn1_0898.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE03843 ; ACE03843 ; Cphamn1_0898 .
GeneIDi 6374565.
KEGGi cpb:Cphamn1_0898.
PATRICi 21383934. VBIChlPha121022_0974.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243509.
KOi K01462.
OMAi MEMVFYP.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci CPHA331678:GHME-923-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BS1.

Entry informationi

Entry nameiDEF_CHLPB
AccessioniPrimary (citable) accession number: B3EPG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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