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B3EP06

- MDH_CHLPB

UniProt

B3EP06 - MDH_CHLPB

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Chlorobium phaeobacteroides (strain BS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321NADUniRule annotation
Binding sitei81 – 811SubstrateUniRule annotation
Binding sitei87 – 871SubstrateUniRule annotation
Binding sitei94 – 941NADUniRule annotation
Binding sitei119 – 1191SubstrateUniRule annotation
Binding sitei150 – 1501SubstrateUniRule annotation
Active sitei174 – 1741Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADUniRule annotation
Nucleotide bindingi117 – 1193NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCPHA331678:GHME-857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Cphamn1_0832
OrganismiChlorobium phaeobacteroides (strain BS1)
Taxonomic identifieri331678 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000001228: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Malate dehydrogenasePRO_1000126129Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331678.Cphamn1_0832.

Structurei

3D structure databases

ProteinModelPortaliB3EP06.
SMRiB3EP06. Positions 1-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiNCKMLES.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B3EP06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKITVIGAGH VGATAAHRIA EQQLANTVVL FDILEGIPQG KALDMYESGP
60 70 80 90 100
VGLFDTKVYG TTDYNDTADS DIILITAGMA RKPGMSREDL LMKNATIVKE
110 120 130 140 150
VTDQVVRFSK NPIIIMVSNP LDIMTHVGYI RSKLPKERVL GMAGVLDSAR
160 170 180 190 200
FRSFIAEELN VSMRDINAFV LGGHGDSMVP VVKYTSVAGI PLTELMAQDT
210 220 230 240 250
IEQLVDRTRK GGAEIVNYLK NGSAYYAPAS SAVEMIDAIV NDRKRILPCS
260 270 280 290 300
ALLEGQYGIN NVYIGAPVKL GKNGIEQILE IDLDAPELDA LRKSAAIVEE
310
NCNNLASLLA
Length:310
Mass (Da):33,495
Last modified:July 22, 2008 - v1
Checksum:i948F40530293C7CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001101 Genomic DNA. Translation: ACE03783.1.
RefSeqiWP_012474271.1. NC_010831.1.
YP_001959264.1. NC_010831.1.

Genome annotation databases

EnsemblBacteriaiACE03783; ACE03783; Cphamn1_0832.
GeneIDi6374499.
KEGGicpb:Cphamn1_0832.
PATRICi21383786. VBIChlPha121022_0900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001101 Genomic DNA. Translation: ACE03783.1 .
RefSeqi WP_012474271.1. NC_010831.1.
YP_001959264.1. NC_010831.1.

3D structure databases

ProteinModelPortali B3EP06.
SMRi B3EP06. Positions 1-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331678.Cphamn1_0832.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE03783 ; ACE03783 ; Cphamn1_0832 .
GeneIDi 6374499.
KEGGi cpb:Cphamn1_0832.
PATRICi 21383786. VBIChlPha121022_0900.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi NCKMLES.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci CPHA331678:GHME-857-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BS1.

Entry informationi

Entry nameiMDH_CHLPB
AccessioniPrimary (citable) accession number: B3EP06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3