B3EN04 (DAPB_CHLPB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Cphamn1_2084

Organism

Chlorobium phaeobacteroides (strain BS1) [Complete proteome] [HAMAP]

Taxonomic identifier

331678 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000093954

Sequences

	Sequence		Length	Mass (Da)
	B3EN04 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 58415447E5E7CE0D	FASTA	248	26,948
	10 20 30 40 50 60 MKYTLVGNGR MGQQVLGAIE ASGEHTVHDI LDVDAEISEQ SFSGSDVIVD FTVRDAFLVN 70 80 90 100 110 120 LPAMLASRVP VVVGTTGWDR EMSIVRSMVE KSGSSLLYSA NFSLGVNVFL RTVREAARMI 130 140 150 160 170 180 APFEDFDIAF SEQHHTAKAD FPSGTALRAA EMILEANSRK KSIISQLSTD RKIEPDELQV 190 200 210 220 230 240 AAIRLGSVFG QHAAAINSES DDIVVSHTAR NRKGFAGGAV QAGKWLAQKH TEQPGFYTMD DFLDEVLG

References

[1]

"Complete sequence of Chlorobium phaeobacteroides BS1." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Li T., Liu Z., Zhao F. , Overmann J., Bryant D.A., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001101 Genomic DNA. Translation: ACE04993.1.
RefSeq	YP_001960474.1. NC_010831.1.
3D structure databases
ProteinModelPortal	B3EN04.
ModBase	Search...
Protein-protein interaction databases
STRING	B3EN04.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6375778.
GenomeReviews	Gene locus Cphamn1_2084 in contig CP001101_GR.
KEGG	cpb:Cphamn1_2084.
PATRIC	21386578. VBIChlPha121022_2271.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG594002.
OMA	IEISHKS.
ProtClustDB	CLSK637968.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_CHLPB

Accession

Primary (citable) accession number: B3EN04

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program