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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Chlorobium phaeobacteroides (strain BS1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi503MagnesiumUniRule annotation1
Metal bindingi509MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Cphamn1_0552
OrganismiChlorobium phaeobacteroides (strain BS1)
Taxonomic identifieri331678 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000001228 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001479011 – 734Polyribonucleotide nucleotidyltransferaseAdd BLAST734

Interactioni

Protein-protein interaction databases

STRINGi331678.Cphamn1_0552.

Structurei

3D structure databases

ProteinModelPortaliB3EMN6.
SMRiB3EMN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini570 – 629KHUniRule annotationAdd BLAST60
Domaini639 – 713S1 motifUniRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRYMHNYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

B3EMN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIRKEIDLG DGKVITIETG KMAKQADGAT IVRMGDTMVI ATVVSSRTPP
60 70 80 90 100
SPNQDFFPMQ VEYREKYYAA GKFPGGFIKR ESRPSEKEIL SARLIDRALR
110 120 130 140 150
PLFPNGYYQD TQIIISVISS DQLNDADVLG GIAASAAIMV SDIPFANSMS
160 170 180 190 200
EVRVGRINGE FVINPTINEL AQSDIDISIG GTNDTICMLE GEMNEISEAE
210 220 230 240 250
MLEAIRFGHE AIKKICSLQD DIAAEVNKPK RSFLAIDAPD ELKESIKEAC
260 270 280 290 300
EAPLKELAYM PLAKEERAEK TTAVYKSITE QILGRYKNEI TAEDIAADPS
310 320 330 340 350
KALYLNEQII SGHIHAIEKQ VMRHMILDDA KRLDGRKLEE VRPISIELGL
360 370 380 390 400
IPRAHGSALF TRGETQALVV LTLGTKKDAQ MIDTLLDDTE KRFMLHYNFP
410 420 430 440 450
PFSVGETGRV GGVGRREIGH GNLAERAVKK VVPSESEFPY TIRLVSEILE
460 470 480 490 500
SNGSSSMASV CGATLAAMDG GVPLTKPVSG IAMGLIKEDD NYAVLSDILG
510 520 530 540 550
NEDHLGDMDF KVAGTRDGIT ACQMDIKIDG LDYHILEKAL EQSKNGRLHI
560 570 580 590 600
LDKMTESIAD PRGEIGQYAP KLSTIQVPVD AIGMIIGKGG ETIRSITEET
610 620 630 640 650
GAQINVDDDG TVTISSPNGE SAAAAIETIK TLISKPEVGT IYMGKVKDIR
660 670 680 690 700
EDLGAFVEIL PRTDGLVHIS EIARERVNKV SDHLKQGDRV KVKLIDIRKD
710 720 730
QRSGKIRYAL SIKALLDMPA ESANGPSAQE EQNQ
Length:734
Mass (Da):80,167
Last modified:July 22, 2008 - v1
Checksum:i637E7CC1A3BD92ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001101 Genomic DNA. Translation: ACE03514.1.
RefSeqiWP_012474005.1. NC_010831.1.

Genome annotation databases

EnsemblBacteriaiACE03514; ACE03514; Cphamn1_0552.
KEGGicpb:Cphamn1_0552.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPNP_CHLPB
AccessioniPrimary (citable) accession number: B3EMN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: June 7, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families