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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlorobium phaeobacteroides (strain BS1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHA331678:GHME-573-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Cphamn1_0551
OrganismiChlorobium phaeobacteroides (strain BS1)
Taxonomic identifieri331678 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000001228 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Leucine--tRNA ligasePRO_1000091304Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331678.Cphamn1_0551.

Structurei

3D structure databases

ProteinModelPortaliB3EMN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B3EMN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYDFQSIEK KWQAYWNEHQ TFLTKETVDK PKYYVLDMFP YPSGSGLHVG
60 70 80 90 100
HLEGYTATDI ISRYKRSRGH NVLHPMGWDA FGLPAEQFAI KTGTHPKVIT
110 120 130 140 150
EKNVSSFKDT LMRMGFSYDW NREINTTDPG YYAWTQWIFL QLLDRGLAYT
160 170 180 190 200
SEIDVNWCEE LKTVLANEEV AEKVADGHAV VRKPLRQWVL KITAYAERLL
210 220 230 240 250
SDLDLVDWPE SVKQMQRNWI GRSEGVEIDF QLPCHRTSLK VYTTRPDTLF
260 270 280 290 300
GATYLVISPE HPMAEKLATA EHLIEAKNYI EEAKRKTELE RTGLQKEKTG
310 320 330 340 350
VFTGSFAVNP ANGQALPVWI SDFVLTSYGT GAIMSVPAHD GRDWEFAKKF
360 370 380 390 400
DLPIVEVIKS PHDVEEAVFE EKGSVCINSS NDDISLDGLP FETSFGVMAD
410 420 430 440 450
WLEKKGTGKR TVKYKLRDWI FSRQRYWGEP IPVKYYEDGT LRPESDLPLT
460 470 480 490 500
LPDIEAYEPT TTGESPLANI SEWLYGTDEN GSFRRETNTM PQWAGSCWYY
510 520 530 540 550
LRFIDPGNTE KPVDPKKEQY WMNVDLYVGG AEHAVLHLLY ARFWHKVLFD
560 570 580 590 600
LGVVSTKEPF QKLFNQGMIL GEDNEKMSKS RGNVIPADQV LGSYGADAVR
610 620 630 640 650
LYEMFLGPLE QVKPWNTNGI EGVSRFLSRV WRLIYPEPGS MAELNEAPLT
660 670 680 690 700
EDLTRTMHKA VKKITDHTEQ LKFNTAISEM MVFVNELHKS GSRNRTAVET
710 720 730 740 750
LLLLLSPYAP HICEELWEAI GHDTSITEEN WPLFDPALAA DNEVTIAVQV
760 770 780 790 800
NGKLRGTVTA PAGSPKNILL DSARKEESVR KFLDGMSIIK EVVVPDRLVN

FVVKPG
Length:806
Mass (Da):91,859
Last modified:July 22, 2008 - v1
Checksum:i10EA7B28DBCFAFC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001101 Genomic DNA. Translation: ACE03513.1.
RefSeqiWP_012474004.1. NC_010831.1.
YP_001958994.1. NC_010831.1.

Genome annotation databases

EnsemblBacteriaiACE03513; ACE03513; Cphamn1_0551.
KEGGicpb:Cphamn1_0551.
PATRICi21383168. VBIChlPha121022_0594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001101 Genomic DNA. Translation: ACE03513.1.
RefSeqiWP_012474004.1. NC_010831.1.
YP_001958994.1. NC_010831.1.

3D structure databases

ProteinModelPortaliB3EMN5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi331678.Cphamn1_0551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACE03513; ACE03513; Cphamn1_0551.
KEGGicpb:Cphamn1_0551.
PATRICi21383168. VBIChlPha121022_0594.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciCPHA331678:GHME-573-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BS1.

Entry informationi

Entry nameiSYL_CHLPB
AccessioniPrimary (citable) accession number: B3EMN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: April 29, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.