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B3EMN5

- SYL_CHLPB

UniProt

B3EMN5 - SYL_CHLPB

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Protein
Leucine--tRNA ligase
Gene
leuS, Cphamn1_0551
Organism
Chlorobium phaeobacteroides (strain BS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHA331678:GHME-573-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Cphamn1_0551
OrganismiChlorobium phaeobacteroides (strain BS1)
Taxonomic identifieri331678 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000001228: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Leucine--tRNA ligaseUniRule annotation
PRO_1000091304Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331678.Cphamn1_0551.

Structurei

3D structure databases

ProteinModelPortaliB3EMN5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiERYWMNV.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B3EMN5-1 [UniParc]FASTAAdd to Basket

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MRYDFQSIEK KWQAYWNEHQ TFLTKETVDK PKYYVLDMFP YPSGSGLHVG    50
HLEGYTATDI ISRYKRSRGH NVLHPMGWDA FGLPAEQFAI KTGTHPKVIT 100
EKNVSSFKDT LMRMGFSYDW NREINTTDPG YYAWTQWIFL QLLDRGLAYT 150
SEIDVNWCEE LKTVLANEEV AEKVADGHAV VRKPLRQWVL KITAYAERLL 200
SDLDLVDWPE SVKQMQRNWI GRSEGVEIDF QLPCHRTSLK VYTTRPDTLF 250
GATYLVISPE HPMAEKLATA EHLIEAKNYI EEAKRKTELE RTGLQKEKTG 300
VFTGSFAVNP ANGQALPVWI SDFVLTSYGT GAIMSVPAHD GRDWEFAKKF 350
DLPIVEVIKS PHDVEEAVFE EKGSVCINSS NDDISLDGLP FETSFGVMAD 400
WLEKKGTGKR TVKYKLRDWI FSRQRYWGEP IPVKYYEDGT LRPESDLPLT 450
LPDIEAYEPT TTGESPLANI SEWLYGTDEN GSFRRETNTM PQWAGSCWYY 500
LRFIDPGNTE KPVDPKKEQY WMNVDLYVGG AEHAVLHLLY ARFWHKVLFD 550
LGVVSTKEPF QKLFNQGMIL GEDNEKMSKS RGNVIPADQV LGSYGADAVR 600
LYEMFLGPLE QVKPWNTNGI EGVSRFLSRV WRLIYPEPGS MAELNEAPLT 650
EDLTRTMHKA VKKITDHTEQ LKFNTAISEM MVFVNELHKS GSRNRTAVET 700
LLLLLSPYAP HICEELWEAI GHDTSITEEN WPLFDPALAA DNEVTIAVQV 750
NGKLRGTVTA PAGSPKNILL DSARKEESVR KFLDGMSIIK EVVVPDRLVN 800
FVVKPG 806
Length:806
Mass (Da):91,859
Last modified:July 22, 2008 - v1
Checksum:i10EA7B28DBCFAFC7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001101 Genomic DNA. Translation: ACE03513.1.
RefSeqiYP_001958994.1. NC_010831.1.

Genome annotation databases

EnsemblBacteriaiACE03513; ACE03513; Cphamn1_0551.
GeneIDi6374215.
KEGGicpb:Cphamn1_0551.
PATRICi21383168. VBIChlPha121022_0594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001101 Genomic DNA. Translation: ACE03513.1 .
RefSeqi YP_001958994.1. NC_010831.1.

3D structure databases

ProteinModelPortali B3EMN5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331678.Cphamn1_0551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE03513 ; ACE03513 ; Cphamn1_0551 .
GeneIDi 6374215.
KEGGi cpb:Cphamn1_0551.
PATRICi 21383168. VBIChlPha121022_0594.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi ERYWMNV.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CPHA331678:GHME-573-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BS1.

Entry informationi

Entry nameiSYL_CHLPB
AccessioniPrimary (citable) accession number: B3EMN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi