B3EMB5 (B3EMB5_CHLPB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Tetraacyldisaccharide 4'-kinase HAMAP MF_00409
EC=2.7.1.130 HAMAP MF_00409

Alternative name(s):
Lipid A 4'-kinase HAMAP MF_00409

Gene names

Name:	lpxK HAMAP MF_00409
Ordered Locus Names:	Cphamn1_0530

Organism

Chlorobium phaeobacteroides (strain BS1) [Complete proteome] [HAMAP]

Taxonomic identifier

331678 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) By similarity. HAMAP MF_00409 SAAS SAAS003758
Catalytic activity	ATP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate). HAMAP MF_00409 SAAS SAAS003758
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6. HAMAP MF_00409 SAAS SAAS003758
Sequence similarities	Belongs to the LpxK family. HAMAP MF_00409

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00409 SAAS SAAS003758 Lipid synthesis
Ligand	ATP-binding HAMAP MF_00409 SAAS SAAS003758 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00409 SAAS SAAS003758 EMBL ACE03493.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP tetraacyldisaccharide 4'-kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3EMB5 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: 0E0B42984C9494BE	FASTA	346	37,957
	10 20 30 40 50 60 MHNIRKYLLA PAALLYAAGI FVRNRLFDFG VSTAHKAVLP VISIGNITMG GTGKTPLVDF 70 80 90 100 110 120 VVKYYTSRGL KTAILSRGYK RNSRGVQLVS DGRQILLGSR EAGDECAMLA QNNPGTIVVV 130 140 150 160 170 180 AEKRKDGAGY IAEKFAGRLP DVIILDDGYQ HRQLYRDLDI VIINSTAPFL DDRLIPAGGL 190 200 210 220 230 240 REPGKNLDRA DLLILSKVND PQQSARLEEE LRTTGKPLVK TGIRAGKPVL FAGPENPVPK 250 260 270 280 290 300 RVIGVAGIGQ PESFVDSLQT NGMEVVSHAF FPDHADFPLK SMKSLASKAL RESLSIITTE 310 320 330 340 KDYFRLSSNR PVLETISRVP CYYLPVEIDI IQGKELLEEM LDQAVS

References

[1]

"Complete sequence of Chlorobium phaeobacteroides BS1." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Li T., Liu Z., Zhao F. , Overmann J., Bryant D.A., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001101 Genomic DNA. Translation: ACE03493.1.
RefSeq	YP_001958974.1. NC_010831.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B3EMB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6374194.
GenomeReviews	Gene locus Cphamn1_0530 in contig CP001101_GR.
KEGG	cpb:Cphamn1_0530.
PATRIC	21383128. VBIChlPha121022_0574.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG663914.
OMA	VILMDDG.
ProtClustDB	CLSK637887.
Family and domain databases
HAMAP	MF_00409. LpxK. [Tree]
InterPro	IPR003758. Tetraacyldisaccharide_4-kinase. [Graphical view]
KO	K00912.
Pfam	PF02606. LpxK. 1 hit. [Graphical view]
TIGRFAMs	TIGR00682. LpxK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B3EMB5_CHLPB

Accession

Primary (citable) accession number: B3EMB5

Entry history

Integrated into UniProtKB/TrEMBL:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)