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B3ELV3

- PUR9_CHLPB

UniProt

B3ELV3 - PUR9_CHLPB

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Chlorobium phaeobacteroides (strain BS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCPHA331678:GHME-1926-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Cphamn1_1877
OrganismiChlorobium phaeobacteroides (strain BS1)
Taxonomic identifieri331678 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000001228: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Bifunctional purine biosynthesis protein PurHPRO_1000096051Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331678.Cphamn1_1877.

Structurei

3D structure databases

ProteinModelPortaliB3ELV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiDEIACCA.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B3ELV3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDPVIKRAL VSVSDKSGVV EFCRELSSMG VEIFSTGGTL RKLQESGVAA
60 70 80 90 100
ASISTITGFP EIMDGRVKTL HPKIHGGLLA VRDNADHIAQ ARDNGIGFID
110 120 130 140 150
MVVVNLYPFQ ETVAKPDVTF EEAIENIDIG GPSMLRSAAK NHESVTVITE
160 170 180 190 200
SADYRTVLDE MRENNGATTR STRLKLAGKV FTLTSRYDRA IADYLAASSE
210 220 230 240 250
GEASSEAGSI SVRLEKEIDM RYGENPHQNA GFYRMDDGSG SRSFEEYFRK
260 270 280 290 300
LHGKDLSYNN MLDTAAATAL IEEFRDEAPA VVIIKHTNPC GVAQADTLVE
310 320 330 340 350
AYRKAFSTDT QSPFGGIIAC NRPLDMETAK AIDEIFTEIL IAPAYEEGVL
360 370 380 390 400
DMLMKKKNRR LLLQRKPLLQ EVTEYKSTRF GMLVQERDSR IASRDDLKVV
410 420 430 440 450
TKRQPSAQEL DDLMFAWKIC KHVKSNTIVY VKNRQTVGVG AGQMSRVDSA
460 470 480 490 500
KIARSKAAEA GLDLNGSAVA SDAFFPFADG LLAAAEAGAM AVIQPGGSVR
510 520
DDEVIAAADE HDLAMVFTSM RHFKH
Length:525
Mass (Da):57,423
Last modified:July 22, 2008 - v1
Checksum:i46175CF2B63A0D03
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001101 Genomic DNA. Translation: ACE04794.1.
RefSeqiYP_001960275.1. NC_010831.1.

Genome annotation databases

EnsemblBacteriaiACE04794; ACE04794; Cphamn1_1877.
GeneIDi6375568.
KEGGicpb:Cphamn1_1877.
PATRICi21386134. VBIChlPha121022_2052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001101 Genomic DNA. Translation: ACE04794.1 .
RefSeqi YP_001960275.1. NC_010831.1.

3D structure databases

ProteinModelPortali B3ELV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331678.Cphamn1_1877.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE04794 ; ACE04794 ; Cphamn1_1877 .
GeneIDi 6375568.
KEGGi cpb:Cphamn1_1877.
PATRICi 21386134. VBIChlPha121022_2052.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi DEIACCA.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CPHA331678:GHME-1926-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BS1.

Entry informationi

Entry nameiPUR9_CHLPB
AccessioniPrimary (citable) accession number: B3ELV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3