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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Chlorobium phaeobacteroides (strain BS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Multifunctional enzyme, Transferase
Biological processPurine biosynthesis

Enzyme and pathway databases

BioCyciCPHA331678:G1GCA-1906-MONOMER
UniPathwayiUPA00074; UER00133
UPA00074; UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Cphamn1_1877
OrganismiChlorobium phaeobacteroides (strain BS1)
Taxonomic identifieri331678 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000001228 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000960511 – 525Bifunctional purine biosynthesis protein PurHAdd BLAST525

Proteomic databases

PRIDEiB3ELV3

Interactioni

Protein-protein interaction databases

STRINGi331678.Cphamn1_1877

Structurei

3D structure databases

ProteinModelPortaliB3ELV3
SMRiB3ELV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 149MGS-likePROSITE-ProRule annotationAdd BLAST149

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DC1 Bacteria
COG0138 LUCA
HOGENOMiHOG000230373
KOiK00602
OMAiDLLFAWK
OrthoDBiPOG091H00UT

Family and domain databases

Gene3Di3.40.140.20, 2 hits
3.40.50.1380, 1 hit
HAMAPiMF_00139 PurH, 1 hit
InterProiView protein in InterPro
IPR024051 AICAR_Tfase_dup_dom_sf
IPR016193 Cytidine_deaminase-like
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR002695 PurH-like
PANTHERiPTHR11692 PTHR11692, 1 hit
PfamiView protein in Pfam
PF01808 AICARFT_IMPCHas, 1 hit
PF02142 MGS, 1 hit
PIRSFiPIRSF000414 AICARFT_IMPCHas, 1 hit
SMARTiView protein in SMART
SM00798 AICARFT_IMPCHas, 1 hit
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
SSF53927 SSF53927, 1 hit
TIGRFAMsiTIGR00355 purH, 1 hit
PROSITEiView protein in PROSITE
PS51855 MGS, 1 hit

Sequencei

Sequence statusi: Complete.

B3ELV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPVIKRAL VSVSDKSGVV EFCRELSSMG VEIFSTGGTL RKLQESGVAA
60 70 80 90 100
ASISTITGFP EIMDGRVKTL HPKIHGGLLA VRDNADHIAQ ARDNGIGFID
110 120 130 140 150
MVVVNLYPFQ ETVAKPDVTF EEAIENIDIG GPSMLRSAAK NHESVTVITE
160 170 180 190 200
SADYRTVLDE MRENNGATTR STRLKLAGKV FTLTSRYDRA IADYLAASSE
210 220 230 240 250
GEASSEAGSI SVRLEKEIDM RYGENPHQNA GFYRMDDGSG SRSFEEYFRK
260 270 280 290 300
LHGKDLSYNN MLDTAAATAL IEEFRDEAPA VVIIKHTNPC GVAQADTLVE
310 320 330 340 350
AYRKAFSTDT QSPFGGIIAC NRPLDMETAK AIDEIFTEIL IAPAYEEGVL
360 370 380 390 400
DMLMKKKNRR LLLQRKPLLQ EVTEYKSTRF GMLVQERDSR IASRDDLKVV
410 420 430 440 450
TKRQPSAQEL DDLMFAWKIC KHVKSNTIVY VKNRQTVGVG AGQMSRVDSA
460 470 480 490 500
KIARSKAAEA GLDLNGSAVA SDAFFPFADG LLAAAEAGAM AVIQPGGSVR
510 520
DDEVIAAADE HDLAMVFTSM RHFKH
Length:525
Mass (Da):57,423
Last modified:July 22, 2008 - v1
Checksum:i46175CF2B63A0D03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001101 Genomic DNA Translation: ACE04794.1
RefSeqiWP_012475271.1, NC_010831.1

Genome annotation databases

EnsemblBacteriaiACE04794; ACE04794; Cphamn1_1877
KEGGicpb:Cphamn1_1877

Similar proteinsi

Entry informationi

Entry nameiPUR9_CHLPB
AccessioniPrimary (citable) accession number: B3ELV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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