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B3ELU5

- UPPP_CHLPB

UniProt

B3ELU5 - UPPP_CHLPB

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Chlorobium phaeobacteroides (strain BS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciCPHA331678:GHME-1918-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Cphamn1_1869
    OrganismiChlorobium phaeobacteroides (strain BS1)
    Taxonomic identifieri331678 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
    ProteomesiUP000001228: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Undecaprenyl-diphosphatasePRO_1000197358Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi331678.Cphamn1_1869.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalUniRule annotationAdd
    BLAST
    Transmembranei87 – 10721HelicalUniRule annotationAdd
    BLAST
    Transmembranei116 – 13621HelicalUniRule annotationAdd
    BLAST
    Transmembranei153 – 17321HelicalUniRule annotationAdd
    BLAST
    Transmembranei196 – 21621HelicalUniRule annotationAdd
    BLAST
    Transmembranei229 – 24921HelicalUniRule annotationAdd
    BLAST
    Transmembranei256 – 27621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiTEVNRIT.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3ELU5-1 [UniParc]FASTAAdd to Basket

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    MTLFEAIILG IVQGLTEFLP ISSTAHLRIV PALAGWQDPG AAFSAIVQIG    50
    TLAAVLIYFY KDIHSITRGV FDGLRSGRPF ETQESRMGWM IAAGTMPIVI 100
    LGLLFKTEIE TSLRSLYWIS VALIVLALML TLAEWLMKRR ADKGLKAKTM 150
    NDIGWKEALL IGLAQSIALI PGSSRSGVTI TGGLFLNLSR ETAARFSFLL 200
    SLPAVFAAGI YQLYETRDQL MASGSDLLNL AVATLFAGIV GYASIAFLIN 250
    YLKQHSTALF ILYRIALGVG ILGLIANGYL QA 282
    Length:282
    Mass (Da):30,518
    Last modified:July 22, 2008 - v1
    Checksum:i6E1E952DA220EA12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001101 Genomic DNA. Translation: ACE04786.1.
    RefSeqiWP_012475263.1. NC_010831.1.
    YP_001960267.1. NC_010831.1.

    Genome annotation databases

    EnsemblBacteriaiACE04786; ACE04786; Cphamn1_1869.
    GeneIDi6375560.
    KEGGicpb:Cphamn1_1869.
    PATRICi21386112. VBIChlPha121022_2041.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001101 Genomic DNA. Translation: ACE04786.1 .
    RefSeqi WP_012475263.1. NC_010831.1.
    YP_001960267.1. NC_010831.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 331678.Cphamn1_1869.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACE04786 ; ACE04786 ; Cphamn1_1869 .
    GeneIDi 6375560.
    KEGGi cpb:Cphamn1_1869.
    PATRICi 21386112. VBIChlPha121022_2041.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi TEVNRIT.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci CPHA331678:GHME-1918-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BS1.

    Entry informationi

    Entry nameiUPPP_CHLPB
    AccessioniPrimary (citable) accession number: B3ELU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3