B3ELA4 (AROE_CHLPB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Cphamn1_1774

Organism

Chlorobium phaeobacteroides (strain BS1) [Complete proteome] [HAMAP]

Taxonomic identifier

331678 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000100109
Regions
	Nucleotide binding	130 – 134	5	NADP By similarity
Sites
	Active site	70	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	B3ELA4 [UniParc]. Last modified July 22, 2008. Version 1. Checksum: E6E9E22B93352032	FASTA	293	31,239
	10 20 30 40 50 60 MYSAKKILGL IGRNVGYSYS PYIHNTAAEK LGLGYYYTIF NISSHDLVPS ALEGAKALGI 70 80 90 100 110 120 AGFNVTIPYK KTVVACMDKL SPEAEAIGAV NTIVNDNGTL IGYNTDIAGI VIPLEPYASM 130 140 150 160 170 180 IDAQPVGIFG NGGAAMAAIE ALSTCFTPSG IRLFVRQREK GSELCRQFKD KNLPIPLSTH 190 200 210 220 230 240 TLDDHTAQHN CRLLINATPI GTKGLDTAPA GSIIPSGSGV VHSGQIIFDM VYNPVETQLL 250 260 270 280 290 QLAKATGAIA IPGIEMLIGQ ASRSFEIWTG KAMPVTTVRN KLQELLLTEK RSS

References

[1]

"Complete sequence of Chlorobium phaeobacteroides BS1." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Li T., Liu Z., Zhao F. , Overmann J., Bryant D.A., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001101 Genomic DNA. Translation: ACE04692.1.
RefSeq	YP_001960173.1. NC_010831.1.
3D structure databases
ProteinModelPortal	B3ELA4.
ModBase	Search...
Protein-protein interaction databases
STRING	B3ELA4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6375461.
GenomeReviews	Gene locus Cphamn1_1774 in contig CP001101_GR.
KEGG	cpb:Cphamn1_1774.
PATRIC	21385898. VBIChlPha121022_1938.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	LGIAGFN.
ProtClustDB	CLSK637945.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_CHLPB

Accession

Primary (citable) accession number: B3ELA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program