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B3EL75 (ADE_CHLPB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2
Alternative name(s):
Adenine aminohydrolase
Short name=AAH
Gene names
Ordered Locus Names:Cphamn1_1745
OrganismChlorobium phaeobacteroides (strain BS1) [Complete proteome] [HAMAP]
Taxonomic identifier331678 [NCBI]
Taxonomic lineageBacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962

Catalytic activity

Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Adenine deaminase HAMAP MF_01962
PRO_1000146566

Sites

Active site1971Proton donor By similarity
Metal binding141Zinc; catalytic By similarity
Metal binding161Zinc; catalytic By similarity
Metal binding1941Zinc; catalytic By similarity
Metal binding2751Zinc; catalytic By similarity
Binding site2761Substrate By similarity
Site2181Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
B3EL75 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: 861AA6632C71CCC3

FASTA33537,789
        10         20         30         40         50         60 
MNEYIKGLPK AELHLHIEGT LEPEMMIDIG KRNGVPLPYP DAEAAREAYA FKDLQSFLDI 

        70         80         90        100        110        120 
YYQAASVLLC EQDFYDLTMA YLKKARSQNV RHAEIFFDPQ THTSRGIAFD TVITGINNAL 

       130        140        150        160        170        180 
RDGEQNLGIT SKLIMCILRH LSQDEGLKTL EQALEYKGVI AGIGLDSSEL GNPPDKFRSL 

       190        200        210        220        230        240 
YERAHKEGFL TVAHAGEEGH ADYIWQALNT LHVARIDHGV HCMEDETLIH TLVERQIPLT 

       250        260        270        280        290        300 
VCPLSNVRLG VFSSMEEHNL KKMLDRELSV TVNSDDPAYF GGYVNENYLA VQQALTLERK 

       310        320        330 
DLVRLAVNSF TASFLTQEKK QQHIAAIHTF DKNIT

« Hide

References

[1]"Complete sequence of Chlorobium phaeobacteroides BS1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Li T., Liu Z., Zhao F. expand/collapse author list , Overmann J., Bryant D.A., Richardson P.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001101 Genomic DNA. Translation: ACE04663.1.
RefSeqYP_001960144.1. NC_010831.1.

3D structure databases

ProteinModelPortalB3EL75.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3EL75.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6375432.
GenomeReviewsGene locus Cphamn1_1745 in contig CP001101_GR.
KEGGcpb:Cphamn1_1745.
PATRIC21385834. VBIChlPha121022_1906.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG630382.
OMAENFHALY.

Family and domain databases

HAMAPMF_01962. Adenine_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameADE_CHLPB
AccessionPrimary (citable) accession number: B3EL75
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 22, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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