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Protein

Catalase-peroxidase

Gene

katG

Organism
Chlorobium phaeobacteroides (strain BS1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei94 – 941Transition state stabilizerUniRule annotation
Active sitei98 – 981Proton acceptorUniRule annotation
Metal bindingi261 – 2611Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciCPHA331678:GHME-159-MONOMER.

Protein family/group databases

PeroxiBasei3650. CphCP01_BS1.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Cphamn1_0152
OrganismiChlorobium phaeobacteroides (strain BS1)
Taxonomic identifieri331678 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000001228 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Catalase-peroxidasePRO_0000354759Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki97 ↔ 220Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-246)UniRule annotation
Cross-linki220 ↔ 246Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi331678.Cphamn1_0152.

Structurei

3D structure databases

ProteinModelPortaliB3EKE9.
SMRiB3EKE9. Positions 22-732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3EKE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEHSRCPVT GRTAGNPVAG GGIANRDWWP NQLHLDMLHQ HSSLSNPMEE
60 70 80 90 100
AFKYKEEFGK LDLKAVKKDL YTLMTDSQEW WPADYGHYGG LFIRMTWHSA
110 120 130 140 150
GTYRTGDGRG GGGTGNQRFA PLNSWPDNAN LDKARRLLWP IKQKYGKKLS
160 170 180 190 200
WADLMILAGN YALESMGFKT FGFGGGRVDI WEPEEDIYWG KEVEWLDNKR
210 220 230 240 250
YSGERDLENP LAAVQMGLIY VNPEGPDGKP DPVAAGKDIR ETFGRMAMND
260 270 280 290 300
EETVALVAGG HTFGKCHGVG DPKLVGPEPE AADIEEQGLG WKSGYGSGKG
310 320 330 340 350
DETMTSGLEG AWTPDPIHWD MGYLGMLFKY EWELTKSPAG AWQWKPTDVA
360 370 380 390 400
EEDLAPAAHD PSKRVPTMMT TADLAMRMDP IYGPISRRYY EHPDQFADAF
410 420 430 440 450
ARAWFKLTHR DMGPKSRYLG TEVPEEDLIW QDPVPAVDHE LIGDREIAEL
460 470 480 490 500
KKRLLASGLS IPELVSTAWA SASTFRGSDK RGGANGARIR LAPQKDWEVN
510 520 530 540 550
QPEQLKIVLQ KLEEIRQEFN DAQSGGKRVS LADLIVLGGC AGVEEAARKA
560 570 580 590 600
GTDVTIPFTP GRTDASQEQT DTESFAVLEP LADGFRNYMK KKYSVSAEEM
610 620 630 640 650
LVDRSQLLTL TAPEMTVLVG GLRVLNVNFG QSPHGVFTTL PETLTNDFFV
660 670 680 690 700
NLLDMGTEWK PLSKEHDTFE GRDRKTGEPR WTATRVDLIF GSNSRLRAIA
710 720 730
EVYGSDNAQE KFVHDFVAAW NKVMNLDRFE LG
Length:732
Mass (Da):81,607
Last modified:July 22, 2008 - v1
Checksum:iD4CBAA5E831DD9E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001101 Genomic DNA. Translation: ACE03127.1.
RefSeqiWP_012473618.1. NC_010831.1.

Genome annotation databases

EnsemblBacteriaiACE03127; ACE03127; Cphamn1_0152.
KEGGicpb:Cphamn1_0152.
PATRICi21382267. VBIChlPha121022_0159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001101 Genomic DNA. Translation: ACE03127.1.
RefSeqiWP_012473618.1. NC_010831.1.

3D structure databases

ProteinModelPortaliB3EKE9.
SMRiB3EKE9. Positions 22-732.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi331678.Cphamn1_0152.

Protein family/group databases

PeroxiBasei3650. CphCP01_BS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACE03127; ACE03127; Cphamn1_0152.
KEGGicpb:Cphamn1_0152.
PATRICi21382267. VBIChlPha121022_0159.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciCPHA331678:GHME-159-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_CHLPB
AccessioniPrimary (citable) accession number: B3EKE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 22, 2008
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.