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B3EH28 (GCSPA_CHLL2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Clim_0621
OrganismChlorobium limicola (strain DSM 245 / NBRC 103803) [Complete proteome] [HAMAP]
Taxonomic identifier290315 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000132473

Sequences

Sequence LengthMass (Da)Tools
B3EH28 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: CDC03C1F274C3CBD

FASTA44347,666
        10         20         30         40         50         60 
MPFIVNTDQD REEMLRSIGA SSFDDLIADI PPEIRLDRAL ELFPALSEQE VMTLLEGLSS 

        70         80         90        100        110        120 
ANSSSAGFVS FLGGGAYDHF IPSAVKSIVS RSEFYTAYTP YQAEVSQGTL QAIYEYQSMM 

       130        140        150        160        170        180 
CRLYDMDVAN ASMYDGATAL AEAVLMAMTI TGRELVVLAG KLSPYTGSVL KTYLEASGHG 

       190        200        210        220        230        240 
VIHQNRLENG IGSVDGLKGL MNDRVAAVVV QQPNFYGSLE EVEAIGAAAR ENGALFIVSA 

       250        260        270        280        290        300 
DPVSLGILAA PGSYGADIAV GEGQPLGNHQ NFGGPYLGIF TVRQPYVRKI PGRLVGMTKD 

       310        320        330        340        350        360 
REGNDGFILT LQTREQHIRR EKATSNICTN QALCALQAAV YLSLLGKQGI REVAEQCTLK 

       370        380        390        400        410        420 
AHYLAGRITE LPGYSLKYSA PFFREFVLET PLPAAVIISA MLEKGIFAGY DLSASGENGL 

       430        440 
LVAVTEKRTR AELDSFVQAL AAL 

« Hide

References

[1]"Complete sequence of Chlorobium limicola DSM 245."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Zhao F., Li T., Liu Z. expand/collapse author list , Overmann J., Bryant D.A., Richardson P.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 245 / NBRC 103803.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001097 Genomic DNA. Translation: ACD89708.1.
RefSeqYP_001942687.1. NC_010803.1.

3D structure databases

ProteinModelPortalB3EH28.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290315.Clim_0621.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD89708; ACD89708; Clim_0621.
GeneID6354069.
KEGGcli:Clim_0621.
PATRIC21373241. VBIChlLim118737_0663.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMAYVRKIPG.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycCLIM290315:GHUH-649-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_CHLL2
AccessionPrimary (citable) accession number: B3EH28
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families