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B3EH28

- GCSPA_CHLL2

UniProt

B3EH28 - GCSPA_CHLL2

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Chlorobium limicola (strain DSM 245 / NBRC 103803)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciCLIM290315:GHUH-649-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Clim_0621
OrganismiChlorobium limicola (strain DSM 245 / NBRC 103803)
Taxonomic identifieri290315 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000008841: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000132473Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi290315.Clim_0621.

Structurei

3D structure databases

ProteinModelPortaliB3EH28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiYVRKIPG.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B3EH28-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPFIVNTDQD REEMLRSIGA SSFDDLIADI PPEIRLDRAL ELFPALSEQE
60 70 80 90 100
VMTLLEGLSS ANSSSAGFVS FLGGGAYDHF IPSAVKSIVS RSEFYTAYTP
110 120 130 140 150
YQAEVSQGTL QAIYEYQSMM CRLYDMDVAN ASMYDGATAL AEAVLMAMTI
160 170 180 190 200
TGRELVVLAG KLSPYTGSVL KTYLEASGHG VIHQNRLENG IGSVDGLKGL
210 220 230 240 250
MNDRVAAVVV QQPNFYGSLE EVEAIGAAAR ENGALFIVSA DPVSLGILAA
260 270 280 290 300
PGSYGADIAV GEGQPLGNHQ NFGGPYLGIF TVRQPYVRKI PGRLVGMTKD
310 320 330 340 350
REGNDGFILT LQTREQHIRR EKATSNICTN QALCALQAAV YLSLLGKQGI
360 370 380 390 400
REVAEQCTLK AHYLAGRITE LPGYSLKYSA PFFREFVLET PLPAAVIISA
410 420 430 440
MLEKGIFAGY DLSASGENGL LVAVTEKRTR AELDSFVQAL AAL
Length:443
Mass (Da):47,666
Last modified:July 22, 2008 - v1
Checksum:iCDC03C1F274C3CBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001097 Genomic DNA. Translation: ACD89708.1.
RefSeqiWP_012465589.1. NC_010803.1.
YP_001942687.1. NC_010803.1.

Genome annotation databases

EnsemblBacteriaiACD89708; ACD89708; Clim_0621.
GeneIDi6354069.
KEGGicli:Clim_0621.
PATRICi21373241. VBIChlLim118737_0663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001097 Genomic DNA. Translation: ACD89708.1 .
RefSeqi WP_012465589.1. NC_010803.1.
YP_001942687.1. NC_010803.1.

3D structure databases

ProteinModelPortali B3EH28.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290315.Clim_0621.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD89708 ; ACD89708 ; Clim_0621 .
GeneIDi 6354069.
KEGGi cli:Clim_0621.
PATRICi 21373241. VBIChlLim118737_0663.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi YVRKIPG.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci CLIM290315:GHUH-649-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 245 / NBRC 103803.

Entry informationi

Entry nameiGCSPA_CHLL2
AccessioniPrimary (citable) accession number: B3EH28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3