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B3EH05

- SYL_CHLL2

UniProt

B3EH05 - SYL_CHLL2

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Protein

Leucine--tRNA ligase

Gene
leuS, Clim_0598
Organism
Chlorobium limicola (strain DSM 245 / NBRC 103803)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCLIM290315:GHUH-626-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Clim_0598
OrganismiChlorobium limicola (strain DSM 245 / NBRC 103803)
Taxonomic identifieri290315 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000008841: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligaseUniRule annotationPRO_1000091302Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290315.Clim_0598.

Structurei

3D structure databases

ProteinModelPortaliB3EH05.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotationAdd
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiERYWMNV.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B3EH05-1 [UniParc]FASTAAdd to Basket

« Hide

MRYEFSAIEK KWQAIWQENG TFKTGESTEK PKYYVLDMFP YPSGSGLHVG    50
HLEGYTASDI IARFKRSRGF NVLHPMGWDA FGLPAEQYAI KTGTHPKITT 100
ENNIRSFRET LQAMGFSYDW SKEINTTDPA YFKWTQWIFL RLYEMGLAYM 150
SDVDVNWCEE LKTVLANEEV DEKIADGYTV VRKPLRQWVL KITAYAERLL 200
ADLDELEWPE NVKQMQRNWI GRSEGVEIDF ELRCHGKNLR VYTTRPDTLF 250
GATYLVVSPE HPLAEKLATA DNLKEVKAYI SRAKLKTELE RTGLQKDKTG 300
VFTGSYAINP ATGNPLPVWI SDFVLISYGT GAIMSVPAHD SRDWEFAKKF 350
DLPIIEVIKS PHDVNDAVFE GKESVPVNSS NSEITIDGLP FREAFDTMAS 400
WLEKKGAGKR TINYKLRDWI FSRQRYWGEP IPIKHYEDGT LRTETILPLT 450
LPDVEAYQPS ETGESPLATI HDWLYGSDEF GSFRRETNTM PQWAGSCWYY 500
LRFIDPENSG RLIDPEREKY WMNVDLYIGG AEHAVLHLLY ARFWHKVLFD 550
LNVVSTVEPF RKLFNQGMIL GEDNEKMSKS RGNVIPADHV LKTYGADAVR 600
LYEMFLGPLE QVKPWNTNGI EGISRFLGKV WRLVYPEQEG NKAELTDETM 650
PEELLRRLHK TIRKVTEDTE ALKFNTAIAE MMVLVNELQR NGCRNRTAVE 700
SMILLLAPYA PHIAEELWQA TGHTGSISNE PFPNYVAGLA TDSVVQIAVQ 750
VNGKLRGTFS TPAGTPQNSL IETARNVESV MKFLEGKAIM REIVVPDKLV 800
NFAVK 805
Length:805
Mass (Da):91,997
Last modified:July 22, 2008 - v1
Checksum:iD4F3FE28F9E92DF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001097 Genomic DNA. Translation: ACD89685.1.
RefSeqiWP_012465566.1. NC_010803.1.
YP_001942664.1. NC_010803.1.

Genome annotation databases

EnsemblBacteriaiACD89685; ACD89685; Clim_0598.
GeneIDi6354046.
KEGGicli:Clim_0598.
PATRICi21373191. VBIChlLim118737_0638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001097 Genomic DNA. Translation: ACD89685.1 .
RefSeqi WP_012465566.1. NC_010803.1.
YP_001942664.1. NC_010803.1.

3D structure databases

ProteinModelPortali B3EH05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290315.Clim_0598.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD89685 ; ACD89685 ; Clim_0598 .
GeneIDi 6354046.
KEGGi cli:Clim_0598.
PATRICi 21373191. VBIChlLim118737_0638.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi ERYWMNV.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CLIM290315:GHUH-626-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 245 / NBRC 103803.

Entry informationi

Entry nameiSYL_CHLL2
AccessioniPrimary (citable) accession number: B3EH05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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