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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciCLIM290315:G1GC7-175-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Clim_0163
OrganismiChlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)
Taxonomic identifieri290315 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000008841 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001324961 – 486Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi290315.Clim_0163

Structurei

3D structure databases

ProteinModelPortaliB3EEC8
SMRiB3EEC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B3EEC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEKLIFDLS REGRKGYSLS GNDIPELSIE TVLPAKFLRT EPADLPEVPE
60 70 80 90 100
SEVVRHFIRL SNMNYHVDKN MYPLGSCTMK YNPKVNDAAC DLAGFSELHP
110 120 130 140 150
LQPEKTVQGA LQMMYELSGM LAEIAGMSAV TLQPAAGAHG ELTGILLIKK
160 170 180 190 200
YHEARGSKRS KLLVVDSAHG TNPASAAIAG YEIISVSSNA DGRTDLGDLK
210 220 230 240 250
AKLDGEVAAL MLTNPNTIGL FEKDILTIAQ MVHENGSLLY MDGANMNALL
260 270 280 290 300
GITRPGDMGF DVVHYNLHKS FSAPHGGGGP GSGPVGVCEK LIPYLPVPVI
310 320 330 340 350
ERIETPEGSS FRLNTDHPES IGRMMNFYGN FSVLIRAYTY IRMLGATGLR
360 370 380 390 400
RVSENAIINA NYLLSRLDSR YDLPYPKPVL HEFCLSGDRQ KKAHGVKTLD
410 420 430 440 450
IAKRLLDYGY HAPTIYFPLI VSEALMIEPT ETETRETLDL FAEALLCIAD
460 470 480
EAENSPDLLR SAPVNTPVKR LDEAQASRQL NICCQG
Length:486
Mass (Da):53,191
Last modified:July 22, 2008 - v1
Checksum:iDF6C9ED29002A2E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001097 Genomic DNA Translation: ACD89262.1
RefSeqiWP_012465143.1, NC_010803.1

Genome annotation databases

EnsemblBacteriaiACD89262; ACD89262; Clim_0163
KEGGicli:Clim_0163

Similar proteinsi

Entry informationi

Entry nameiGCSPB_CHLL2
AccessioniPrimary (citable) accession number: B3EEC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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