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B3EEC8

- GCSPB_CHLL2

UniProt

B3EEC8 - GCSPB_CHLL2

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Chlorobium limicola (strain DSM 245 / NBRC 103803)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciCLIM290315:GHUH-175-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:Clim_0163
    OrganismiChlorobium limicola (strain DSM 245 / NBRC 103803)
    Taxonomic identifieri290315 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
    ProteomesiUP000008841: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132496Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei269 – 2691N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiB3EEC8.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi290315.Clim_0163.

    Structurei

    3D structure databases

    ProteinModelPortaliB3EEC8.
    SMRiB3EEC8. Positions 4-485.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiKPVMHEF.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3EEC8-1 [UniParc]FASTAAdd to Basket

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    MIEKLIFDLS REGRKGYSLS GNDIPELSIE TVLPAKFLRT EPADLPEVPE    50
    SEVVRHFIRL SNMNYHVDKN MYPLGSCTMK YNPKVNDAAC DLAGFSELHP 100
    LQPEKTVQGA LQMMYELSGM LAEIAGMSAV TLQPAAGAHG ELTGILLIKK 150
    YHEARGSKRS KLLVVDSAHG TNPASAAIAG YEIISVSSNA DGRTDLGDLK 200
    AKLDGEVAAL MLTNPNTIGL FEKDILTIAQ MVHENGSLLY MDGANMNALL 250
    GITRPGDMGF DVVHYNLHKS FSAPHGGGGP GSGPVGVCEK LIPYLPVPVI 300
    ERIETPEGSS FRLNTDHPES IGRMMNFYGN FSVLIRAYTY IRMLGATGLR 350
    RVSENAIINA NYLLSRLDSR YDLPYPKPVL HEFCLSGDRQ KKAHGVKTLD 400
    IAKRLLDYGY HAPTIYFPLI VSEALMIEPT ETETRETLDL FAEALLCIAD 450
    EAENSPDLLR SAPVNTPVKR LDEAQASRQL NICCQG 486
    Length:486
    Mass (Da):53,191
    Last modified:July 22, 2008 - v1
    Checksum:iDF6C9ED29002A2E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001097 Genomic DNA. Translation: ACD89262.1.
    RefSeqiWP_012465143.1. NC_010803.1.
    YP_001942241.1. NC_010803.1.

    Genome annotation databases

    EnsemblBacteriaiACD89262; ACD89262; Clim_0163.
    GeneIDi6356133.
    KEGGicli:Clim_0163.
    PATRICi21372253. VBIChlLim118737_0185.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001097 Genomic DNA. Translation: ACD89262.1 .
    RefSeqi WP_012465143.1. NC_010803.1.
    YP_001942241.1. NC_010803.1.

    3D structure databases

    ProteinModelPortali B3EEC8.
    SMRi B3EEC8. Positions 4-485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290315.Clim_0163.

    Proteomic databases

    PRIDEi B3EEC8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD89262 ; ACD89262 ; Clim_0163 .
    GeneIDi 6356133.
    KEGGi cli:Clim_0163.
    PATRICi 21372253. VBIChlLim118737_0185.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi KPVMHEF.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci CLIM290315:GHUH-175-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 245 / NBRC 103803.

    Entry informationi

    Entry nameiGCSPB_CHLL2
    AccessioniPrimary (citable) accession number: B3EEC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3