Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B3EEC8

- GCSPB_CHLL2

UniProt

B3EEC8 - GCSPB_CHLL2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Chlorobium limicola (strain DSM 245 / NBRC 103803)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCLIM290315:GHUH-175-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Clim_0163
OrganismiChlorobium limicola (strain DSM 245 / NBRC 103803)
Taxonomic identifieri290315 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000008841: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiB3EEC8.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi290315.Clim_0163.

Structurei

3D structure databases

ProteinModelPortaliB3EEC8.
SMRiB3EEC8. Positions 4-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiKPVMHEF.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B3EEC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIEKLIFDLS REGRKGYSLS GNDIPELSIE TVLPAKFLRT EPADLPEVPE
60 70 80 90 100
SEVVRHFIRL SNMNYHVDKN MYPLGSCTMK YNPKVNDAAC DLAGFSELHP
110 120 130 140 150
LQPEKTVQGA LQMMYELSGM LAEIAGMSAV TLQPAAGAHG ELTGILLIKK
160 170 180 190 200
YHEARGSKRS KLLVVDSAHG TNPASAAIAG YEIISVSSNA DGRTDLGDLK
210 220 230 240 250
AKLDGEVAAL MLTNPNTIGL FEKDILTIAQ MVHENGSLLY MDGANMNALL
260 270 280 290 300
GITRPGDMGF DVVHYNLHKS FSAPHGGGGP GSGPVGVCEK LIPYLPVPVI
310 320 330 340 350
ERIETPEGSS FRLNTDHPES IGRMMNFYGN FSVLIRAYTY IRMLGATGLR
360 370 380 390 400
RVSENAIINA NYLLSRLDSR YDLPYPKPVL HEFCLSGDRQ KKAHGVKTLD
410 420 430 440 450
IAKRLLDYGY HAPTIYFPLI VSEALMIEPT ETETRETLDL FAEALLCIAD
460 470 480
EAENSPDLLR SAPVNTPVKR LDEAQASRQL NICCQG
Length:486
Mass (Da):53,191
Last modified:July 22, 2008 - v1
Checksum:iDF6C9ED29002A2E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001097 Genomic DNA. Translation: ACD89262.1.
RefSeqiYP_001942241.1. NC_010803.1.

Genome annotation databases

EnsemblBacteriaiACD89262; ACD89262; Clim_0163.
GeneIDi6356133.
KEGGicli:Clim_0163.
PATRICi21372253. VBIChlLim118737_0185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001097 Genomic DNA. Translation: ACD89262.1 .
RefSeqi YP_001942241.1. NC_010803.1.

3D structure databases

ProteinModelPortali B3EEC8.
SMRi B3EEC8. Positions 4-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290315.Clim_0163.

Proteomic databases

PRIDEi B3EEC8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD89262 ; ACD89262 ; Clim_0163 .
GeneIDi 6356133.
KEGGi cli:Clim_0163.
PATRICi 21372253. VBIChlLim118737_0185.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi KPVMHEF.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CLIM290315:GHUH-175-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 245 / NBRC 103803.

Entry informationi

Entry nameiGCSPB_CHLL2
AccessioniPrimary (citable) accession number: B3EEC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3