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Protein

Catalase-peroxidase

Gene

katG

Organism
Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei94Transition state stabilizerUniRule annotation1
Active sitei98Proton acceptorUniRule annotation1
Metal bindingi261Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Clim_0134
OrganismiChlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)
Taxonomic identifieri290315 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000008841 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547581 – 732Catalase-peroxidaseAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki97 ↔ 220Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-246)UniRule annotation
Cross-linki220 ↔ 246Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB3EEA0.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi290315.Clim_0134.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3EEA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQSKCPVT GRTAGHPVAG GGMSNRDWWP NQLPLDMLHQ HSSLVNPMGE
60 70 80 90 100
AFRYKEEFKK LDLGAVKKDL YALMTDSQEW WPADYGHYGG LFIRMAWHSA
110 120 130 140 150
GTYRTSDGRG GGGTGNQRFA PLNSWPDNAN LDKARRLLWP IKQKYGKMLS
160 170 180 190 200
WADLMILAGN CALESMGFRT FGFGGGRVDI WEPEEDIYWG KEVEWLGSNR
210 220 230 240 250
YSGERDLENP LAAVQMGLIY VNPEGPDGNP DPVAAGRDIR ETFARMAMND
260 270 280 290 300
EETVALVAGG HTFGKCHGVG DPNLIGPEPE AAPIEEQGLG WKSGYGSGKG
310 320 330 340 350
DETMTSGLEG AWTPDPIHWD MGYLGMLFKY EWELTKSPAG AWQWKPKDVA
360 370 380 390 400
EEDLAPAAHD PSKRVPTMMT TADLAMRMDP IYGPISRRYY EHPDQFADAF
410 420 430 440 450
ARAWFKLTHR DMGPKSRYLG AEVPAEDLIW QDPVPAVDHE LITEGEIAEL
460 470 480 490 500
KMRILASGLP IPELVSTAWA SASTFRGSDK RGGANGARIR LAPQKEWEVN
510 520 530 540 550
QPEQLQRVLH ELEKIRDTFN GEQSGGKRVS LADLIVLGGC AAVEEAARRA
560 570 580 590 600
GHDVTVPFAP GRTDASQAET DVESFAALEP LADGFRNYAK RKYSVTPEEM
610 620 630 640 650
LIDRSQLLTL TAPEMTVLVG GLRVLGINFR QSPHGVFTRH PETLTNDFFV
660 670 680 690 700
NLLDMGTEWK PVSHEHDTFE GRDRKTGEPS WSATRVDLIF GSNARLRAIA
710 720 730
EVYGSDDAQE KFVHDFVAAW DKVMNLDRFD LS
Length:732
Mass (Da):81,360
Last modified:July 22, 2008 - v1
Checksum:i9E5FCAEE9CD5B544
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001097 Genomic DNA. Translation: ACD89234.1.
RefSeqiWP_012465115.1. NC_010803.1.

Genome annotation databases

EnsemblBacteriaiACD89234; ACD89234; Clim_0134.
KEGGicli:Clim_0134.
PATRICi21372175. VBIChlLim118737_0151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001097 Genomic DNA. Translation: ACD89234.1.
RefSeqiWP_012465115.1. NC_010803.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290315.Clim_0134.

Proteomic databases

PRIDEiB3EEA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD89234; ACD89234; Clim_0134.
KEGGicli:Clim_0134.
PATRICi21372175. VBIChlLim118737_0151.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_CHLL2
AccessioniPrimary (citable) accession number: B3EEA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.