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Protein

Thymidylate kinase

Gene

tmk

Organism
Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 14ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCLIM290315:G1GC7-1537-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:Clim_1510
OrganismiChlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)
Taxonomic identifieri290315 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000008841 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000973841 – 219Thymidylate kinaseAdd BLAST219

Proteomic databases

PRIDEiB3EDD6

Interactioni

Protein-protein interaction databases

STRINGi290315.Clim_1510

Structurei

3D structure databases

ProteinModelPortaliB3EDD6
SMRiB3EDD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD Bacteria
COG0125 LUCA
HOGENOMiHOG000229078
KOiK00943
OMAiFLYTADH
OrthoDBiPOG091H02B9

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR018095 Thymidylate_kin_CS
IPR018094 Thymidylate_kinase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit
PROSITEiView protein in PROSITE
PS01331 THYMIDYLATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

B3EDD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLITFEGIDG AGKSTQIRKL QKLLIGAHID SITLREPGGT EVAEKIRQIL
60 70 80 90 100
LESRHEISPI GELLLFSASR AELVQQVILP AIDNGTTVIL DRFFDSTIAY
110 120 130 140 150
QGYGREIDQV MLQTIITLST FSLQPDITFY LDISPENALM RKFSEKSLPI
160 170 180 190 200
AFDESELDRM ERSGLDFFRK VRQGYLDIIH KNERRFVLLD ALDDPQMIHK
210
RIIASLKERF PVFSGIKTR
Length:219
Mass (Da):24,982
Last modified:July 22, 2008 - v1
Checksum:i1BD63B8901A12D5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001097 Genomic DNA Translation: ACD90561.1
RefSeqiWP_012466437.1, NC_010803.1

Genome annotation databases

EnsemblBacteriaiACD90561; ACD90561; Clim_1510
KEGGicli:Clim_1510

Similar proteinsi

Entry informationi

Entry nameiKTHY_CHLL2
AccessioniPrimary (citable) accession number: B3EDD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health